Antigen-mediated cross-linking of IgE on mast cells triggers a signaling cascade that results in their degranulation and proinflammatory cytokine production, which are key effectors in allergic reactions. The research team led by Prof. Linr...
Autophagy is a self-proteolytic process that degrades intracellular material to enable cellular survival under unfavorable conditions. However, how autophagy is activated in human carcinogenesis remains largely unknown.
Since cartilage and bone tissues have different lineage-specific biological properties, it is challenging to utilize a single type of scaffold to biologically fulfill the both requirements for regenerating these two lineages in osteochondra...
Cancer stem cells are a sub-population of cancer cells that can proliferate extensively, give rise to differentiated cells and form new tumors. None of the existing anticancer therapies effectively target this cell population which is thoug...
A study from Professor Shumin Duan’s group on how an intracellular size filter enhances antigen processing in microglia was recently published on The Journal of Neuroscience (http://www.jneurosci.org/content/35/6/2674, Figure 1).
Researchers from Cancer Institute, the Second Affiliated Hospital Zhejiang University School of Medicine (Prof. Jian Huang group) and University of Louisville School of Medicine (Prof. Jun Yan) found that human colorectal cancer (CRC) ...
Microglia are the primary immune cells in the central nervous system and play important roles in maintaining brain homeostasis. Directed microglial migration to the injured/disease sites in the brain, is key to the microglial immunoresponse...
In the early stage of sudden H7N9 outbreak, the group of academician Lanjuan Li published the paper “Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of vi...
In 2013 January, the famous international academic journal Cell published research paper titled “Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune by Promoting RIG-I Degradation” by Professor Cao Xuetao’s res...
The emergence of multidrug-resistant Gram-negative bacteria, in particular Acinetobacter baumannii and Pseudomonas aeruginosa, is a critical clinical problem worldwide. Antimicrobial peptides (AMPs) have received increasing attention due to...
Human health has been challenged by multidrug resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistan...
Epilepsy is a disabling neurological disorder that affects about 1% of the general population of all ages. About 30% of affected individuals continue to have breakthrough seizures despite appropriate pharmacological anticonvulsant trea...
The body's immune system relies on a spectrum of highly differentiated immune cells to combat external microbial infections. Among which, T lymphocytes play important roles in the immune responses, including directly killing of virus-...
Bcr-Abl tyrosine kinase inhibitors (TKIs) have been a remarkable success for the treatment of Ph(+) chronic myeloid leukemia (CML). However, a significant proportion of patients treated with TKIs develop resistance because of leukemia stem ...