Recently, the group led by Professor Zhi Chen collaborated with Ningbo Second Hospital published their clinical findings on acute-on-chronic liver failure in Hepatology. The study revealed that ACLF patients precipitated by hepatic insults ...
Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes a major limitation of its success clinically. The key molecule or mechanism associated with paclitaxel resistance in ovaria...
Acute liver failure (ALF) is a significant disorder with a high mortality rate of 55%–75% and causes large resource costs. Liver transplantation is the standard therapy for patients with liver failure; however, less than 30% of patien...
Hepatocelluar carcinoma is one of the most common cancers and ranks the second leading cause of cancer death in men and sixth in women over the world. The overall survival of patients with HCC remains unsatisfactory because of a high incide...
The small GTPase Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is as a positive regulator of chondrocyte hypertrophy and endochondral ossification during bone formation, processes that are recapitulated in osteoarthritis (...
Cilia are evolutionarily conserved microtubule-based organelles projecting from the surface of most vertebrate cell types, which play crucial roles in embryonic development and tissue homeostasis. Defects in ciliary assembly or function lea...
A research conducted by the team of Prof. Shumin Duan and Hao Wang from Institution of Neuroscience, School of Basic Medical Sciences discovered new circuit mechanisms for innate fear. This finding was published in Nature Neuroscience on J...
A research conducted by the team of Prof. Shumin Duan and Hao Wang from Institution of Neuroscience, School of Basic Medical Sciences discovered new circuit mechanisms for innate fear. This finding was published in Nature Neuroscience ...
Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sit...
It is widely acknowledged that environmental ultrafine particulate matter (PM) is capable of inducing airway injury since the lung is the first and major target of airborne pollutants. However, the detailed underlying molecular mechanisms m...
Self-assembling of individual molecular building blocks—small-molecule prodrugs—promises to facilitate the construction of nanodrugs without the requirement of adjuvant materials. Unfortunately, rationally designing systemically...
Eukaryotes initiate autophagy to cope with the lack of external nutrients, which requires the activation of the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase Sirtuin 1 (Sirt1). However, the mechanisms underlying the starvat...
October 24th, Zhang Xijun Foundation of the Thirteenth National Youth Outstanding Physiological Research Papers Exchange Conference drew to a successful close in the beautiful Yongji Medical College of Huazhong University of Science and Tec...
Diabetes mellitus (DM) is increasing in prevalence world- wide and afflicts an estimated 6.6% of the global adult population, or approximately 285 million individuals. By 2030, an estimated 350 million people worldwide will be living with D...