A series of previous studies from Chen group have proved that the anti-epileptic effect of low-frequency stimulation(LFS) depends on the targeted brain area, stimulation frequency, waveform and so on. Recently, they found that LFS of certai...
Signaling via the Akt serine/threonine protein kinase plays critical roles in the self-renewal of embryonic stem cells and their malignant counterpart, embryonal carcinoma cells (ECCs). A research team led by Prof. Ying-Jie Wang at th...
The expression of histamine receptor 1-4 (H1- 4R) and histamine methyltransferase was determined in the histamine projection areas which are strongly involved in Parkinson’s disease (PD), i.e. the substantia nigra and striatum, with q...
In postmortem brain material of preclinical Parkinson’s disease (PD), clinical PD, and control subjects, we determined with quantitative in situ hybridization and immunocytochemistry the expression of histidine decarboxylase (HDC)-mRN...
Recently, the research of Chao He and his team from Sir Run Run Shaw Hospital, cooperated with Shanghai Jiaotong University, was published in the Journal of Proteome Research. They firstly compared the secretome of fresh cultured CRC tumor ...
Bone marrow-derived mesenchymal stem cells (MSC) have been shown to home into tumor tissues, where they promote tumor growth and suppress immune rejection. In this study, we tested whether MSCs engineered to express the immune stimulating f...
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and usually develops in patients with liver cirrhosis (LC). Biomarkers that discriminate HCC from LC are important but are limited. In the present study, an ultraperfo...
Stem cell-based therapy to treat liver diseases is a focus of current research.Cell types and the transplantation pathways are the key factorsSo far, most such studies used rodent models to evaluate the therapeutic potential of bone marrow ...
Neuronal histamine is presumed to play a major role in regulating diurnal fluctuations such as sleep-wake rhythm. There were, however, no data showing a biological rhythm of neuronal histamine in human health or in neurodegenerative disorde...
Professor Chao He and his group firstly compared the secretome of fresh cultured CRC tumor tissues and paired normal colorectal (NC) tissues under near physiological conditions. They applied a lectin affinity based approach to enrich secret...
ADP is a key platelet agonist responsible for platelet aggregation and thrombus stability in vivo. Our recent finding indicated that ADP stimulation initiates a PI3K-dependent signaling, which regulates the cleavage of integrin αIIb&b...
The Pictet−Spenglerase strictosidine synthase (STR1) has been recognized as a key enzyme in the biosynthesis of some 2000 indole alkaloids in plants, some with high therapeutic value. In this study, a novel function of STR1 has been d...
In 1996, the phakia intraocular lens (Visian ICL) were firstly implanted in Asia by Dr Ye Shen and relative researches were also underwent at the First Affiliated hospital of Zhejiang University. In 2011, Dr Chixin Du and Yangshun Gu invest...
Liver cirrhosis is the pathologic end stage of chronic liver disease. Increasing evidence suggests that gut flora is implicated in the pathogenesis of liver cirrhosis complications. The aim of our study is to characterize the fecal mi...