Hyperactivation of Wnt/β-catenin signaling is one of the major causes of human colorectal cancer (CRC). A hallmark of Wnt signaling is the nuclear accumulation of β-catenin. Although β-catenin nuclear import and export have been widely i...
On July 27, 2017, Prof. Xuetao Cao (Zhejiang University School of Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences) and his group published a research article in Cell about the identification of histone methyltran...
Polymyxin antibiotics are used as last-resort therapies to treat infections caused by multidrug-resistant Gram-negative bacteria. The plasmid-mediated colistin resistance determinant MCR-1 has been identified in Enterobacteriaceae in China ...
Astrocytes, the most abundant cell type in the brain, have important roles in the central nervous system. In general, astrocyte responds to neuronal activity with calcium waves and modulates synaptic transmission through the release of glio...
Prof. Yu-Dong Zhou, a principal investigator in the Institute of Neuroscience, and his colleagues demonstrate a developmental role of astrocytes in shaping a predisposition to seizure generation. Activation of TLR4-MyD88-ERK1/2 signaling pa...
Prof. Xing Zhang, director of the center of cryo electron microscopy, and his group revealed the structural basis for the stabilization of cleaved rRNAs and paromomycin specificity of Leishmania Do...
MTOR (mechanistic target of rapamycin) plays a crucial role in many major cellular processes and a growing number of proliferative and metabolic diseases. In a study, Prof. Huahao Shen’s group observed that lipopolysaccharide (LPS) st...
Adult hippocampal neurogenesis was impaired in several Alzheimer's disease models overexpressing mutant human amyloid precursor protein (hAPP). However, the effects of wild-type hAPP on adult neurogenesis and whether the impaired adult hipp...
Over the past few years, ideas about bile acids have evolved from their being seen as simple lipid solubilizers to complex metabolic integrators. Recently, synthetic agonists of the bile acid receptors have been developed to serve as next-g...
The Zika virus has been reported in 60 countries and territories worldwide; currently, there are no vaccines or effective drug treatments. In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its li...
It is commonly believed that cholinergic projections from the basal forebrain and brainstem are thought to play important roles in driving arousal and promoting attention.
On Dec 9th, 2015, the group led by Professor Zhefeng Gong published their findings on the cellular and molecular mechanism underlying cold induced growth in fruit fly in Nature Communications. In 19th century, German biologist Carl Bergmann...
Colorectal cancer (CRC) remains one of the most common types of cancers and a leading cause of death worldwide. Previous observational and randomised data indicated that aspirin reduced the risk of colorectal adenomas and cancer, and risk o...
Patients with de-compensated cirrhosis are susceptible to severe bacterial infections (combined with renal dysfunction, hypotension and other organ failures), which exacerbate underlying liver diseases and increase mortality. However, the s...