吴晶晶，女，博士，副教授，博士生导师、硕士生导师，浙江大学求是青年学者

教育工作经历：

2016.12至今 浙江大学医学院病理学与病理生理学系，副教授

2012.8-2016.12 浙江大学医学院病理学与病理生理学系，讲师

2008.10-2010.10 美国Northwestern University，博士联合培养

2007.9-2012.6 山东大学医学院遗传学，理学博士

2001.9-2007.6 山东大学医学院临床医学六年制，医学学士

主持课题：

1. 国家自然科学基金面上项目：HMGA2通过MDM2依赖的途径促进p53泛素化降解的分子机制研究，2018.1-2021.12，60万
2. 国家自然科学基金青年项目：HMGA2通过调控miR-205促进结肠癌细胞侵袭转移的作用及机制研究，2014.1-2016.12，24万
3. 浙江省自然科学基金一般项目：HMGA2与P53蛋白直接结合介导结肠癌细胞周期调控的分子机制研究，2017.1-2019.12，8万
4. 浙江省自然科学基金青年项目：HMGA2促进结肠癌细胞侵袭转移的作用及分子机制研究，2013.1-2015.12，5万
5. 浙江大学自主科研计划项目：HMGA2通过Wnt/β-catenin通路促进结肠癌细胞发生EMT的作用及机制研究，2017.1-2017.12，10万
6. 浙江大学自主科研计划项目：HMGA2通过抑制p53四聚体寡聚化而降低其稳定性的功能和机制研究，2014.1-2015.12，8万

代表性论文：

1. Wang Y, Hu L, Wang J, Li X, Sahengbieke S, Wu J*, Lai M*. HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53. J Pathol. 2018 Dec;246(4):508-518.

2. Sahengbieke S, Wang J, Li X, Wang Y, Lai M, Wu J*. Circulating cell-free high mobility group AT-hook 2 mRNA as a detection marker in the serum of colorectal cancer patients. J Clin Lab Anal. 2018 May;32(4):e22332.

3. Wu J, Wang Y, Xu X, Cao H, Sahengbieke S, Sheng H, Huang Q, Lai M. Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer. Carcinogenesis. 2016 May;37(5):511-21.

4. Wu J, Zhang S, Shan J, Hu Z, Liu X, Chen L, Ren X, Yao L, Sheng H, Li L, Ann D, Yen Y, Wang J, Wang X. Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer. Cancer Lett. 2016 Jul 1;376(2):284-92.

5. Wu J, Lai M, Shao C, Wang J, Wei JJ. STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer. Oncol Rep. 2015 Sep;34(3):1494-502.

6. Wu J, Wei JJ. HMGA2 and high-grade serous ovarian carcinoma. J Mol Med. 2013 Oct;91(10):1155-65.

7. Wu J, Liu Z, Shao C, Gong Y, Hernando E, Lee P, Narita M, Muller W, Liu J, Wei JJ. HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res. 2011 Jan 15;71(2):349-59.

8. Wei JJ, Wu J, Luan C, Yeldandi A, Lee P, Keh P, Liu J. HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes. Am J Surg Pathol. 2010 Jan;34(1):18-26.

9. Wang J, Wu J, Hong J, Chen R, Xu K, Niu W, Peng C, Liu E, Wang J, Liu S, Agrez M, Niu J. PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin αvβ6. Cancer Lett. 2011 Dec 1;311(1):38-47.

10. Liu Z, Liu Q, Xu B, Wu J, Guo C, Zhu F, Yang Q, Gao G, Gong Y, Shao C. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res. 2009 Mar 9;662(1-2):75-83.

11. Zavadil J, Ye H, Liu Z, Wu J, Lee P, Hernando E, Soteropoulos P, Toruner GA, Wei JJ. Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas. PLoS One. 2010 Aug 24;5(8):e12362.

12. Ligr M, Patwa RR, Daniels G, Pan L, Wu X, Li Y, Tian L, Wang Z, Xu R, Wu J, Chen F, Liu J, Wei JJ, Lee P. Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer. PLoS One. 2011;6(10):e26250.

荣誉称号：

2013年 浙江大学求是青年学者

2015年 浙江大学医学院先进工作者

2011年 山东大学光华奖学金