陈光弟，博士、教授、博士生导师。2002年毕业于浙江大学医学院获预防医学专业学士学位；2007年毕业于浙江大学医学院获博士学位，从事电磁场的生物学效应研究；2007-2011年于加拿大UBC医学院从事临床肿瘤学方向的博士后研究；2011年3月起，受聘浙江大学医学部，从事环境医学、肿瘤生物学和职业病学研究。研究成果以第一作者和通讯作者身份发表于Oncogene、JID等SCI收录的Top期刊杂志论文20余篇；主持国家自然科学基金项目3项、省部级科研项目多项。

工作研究领域
1. 环境医学：环境污染（包括物理因素和化学因素）的生物学效应研究及健康风险评估。 2. 职业医学：职业性危害因素的控制评价，职业病和中毒的干预措施研究。 3. 肿瘤生物学：肿瘤标志物的筛选及其应用研究。

课题研究
科研项目
1. 国家自然科学基金面上项目：人绒毛膜癌细胞JAR和JEG-3感受电磁场差异性的机制研究（资助号81573109），2016.1-2019.12，资助50万。

2. 国家自然科学基金面上项目：Tip60蛋白抑制胃癌转移作用研究及机理探索（资助号81172025），2012.1-2015.12，资助55万。

3. 国家自然科学基金青年基金项目：1800 MHz移动电话电磁场诱导HSF细胞gamma-H2AX 焦点形成的后续效应及其发生机制（资助号81102094），2012.1-2014.12，资助23万。

4. 教育部高等学校博士学科点专项科研基金新教师类项目：移动电话射频电磁场诱导细胞gamma-H2AX焦点形成和基因组不稳定性及其发生机制研究（资助号20110101120100），2012.1-2014.12，资助4万。

5. 教育部中央高校基本科研业务费专项浙江大学自主科研计划项目：移动电话射频电磁场对神经胶质瘤细胞DNA损伤的作用研究（资助号2011QNA7018），2011.9-2012.9，资助10万。

6. 教育部中央高校基本科研业务费专项浙江大学自主科研计划项目：移动电话射频电磁场诱导人皮肤成纤维细rH2AX 焦点形成的后续效应研究（资助号2012QNA7019），2012.3-2012.12，资助18万。 (PI:陈光弟，含陈光弟青年基金项目配套经费8万)

7. 浙江大学2014年青年教师交叉研究种子基金：超细微颗粒物细胞作用机制研究（资助号：JCZZ-2013035），2014.1-2015.12，资助2.5万。

8. 浙江大学政策仿真研究基金项目：大气污染颗粒物健康效应研究（资助号：PSYN201401），2014.1-2015.12，资助2.0万。

9. 教育部中央高校基本科研业务费专项浙江大学自主科研计划项目：生物电磁场辐射监测设备的研制（资助号2014QNA7090），2014.1-2014.12，资助20万（PI：钱大宏教授）。

人才项目
10. 浙江省151人才工程资助经费：2014.12-2016.12，资助4万。

11. 浙江省科技厅钱江人才计划项目：射频电磁场敏感神经胶质细胞筛选及其生物学效应研究（资助号：2013R10041），2013.07-2014.06，资助10万。

12. 浙江省卫生厅医坛新秀培养人才项目，2013.11-2014.12，资助5万。

13. 浙江省人事厅留学人员科技活动项目：移动电话辐射对神经胶质瘤细胞基因组稳定性影响，2012.1-2014.12，资助1.5万。

14. 浙江省科学技术协会育才工程培养人员项目，2014.01-2014.12，资助1万元。

15. 浙江大学引进人才计划项目引进人才启动基金，2011.06-2013.12，资助5万。


发表论文
2016
1. Jing Guo, Yue Fei, Junqin Li, Lisan Zhang, Qiong Luo, Guangdi Chen*. Duration and Prevalent Hypertension among Middle-aged and Elderly Chinese Adults, A Cross-sectional Study from CHARLS 2011-2012. BMJ Open 2016 In press.
2. Jing Guo, Liling Su, Xinyuan Zhao, Zhengping Xu, Guangdi Chen*. Relationships between urinary antimony levels and both mortalities and prevalence of cancers and heart diseases in general US population, NHANES 1999-2010. Sci Total Environ. 2016 Jul 8. [Epub ahead of print] (*Co-corresponding Authors) PMID: 27396316
3. Liling Su, Yue Fei, Xiaoxia Wei, Jing Guo, Xiangen Jiang*, Liqin Lu*, Guangdi Chen*. Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk. Leuk Lymphoma. 2016 Apr 7: 1-8. [Epub ahead of print] (*Co-corresponding Authors) PMID: 27054704
4. Dongyu Li, Xinyuan Zhao, Wei Qin, Hequn Zhang, Yue Fei, Liwei Liu, Ken-Tye Yong, Guangdi Chen*, Ben Zhong Tang*, Jun Qian*. Toxicity assessment and long-term three-photonfluorescence imaging of bright aggregation-inducedemission nanodots in zebrafish. Nano Research 2016, 9(7): 1921-1933. (*Co-corresponding Authors)
5. Li Jiang, Xinyuan Zhao, Yue Fei, Dongdong Yu, Jun Qian, Jinguang Tong, Guangdi Chen*, Sailing He*. The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution SPR system.Sci Rep. 2016 Apr 28; 6: 25111. (*Co-corresponding Authors) PMID: 27121618
6. Zhaopin Wang, Lijuan Wang, Shuangshuang Zheng,Zheyuan Ding, Hui Liu, Wen Jin, Yifeng Pan, Zexin Chen, Ying Fei, Guangdi Chen, Zhengping Xu, Yunxian Yu*. Effects of electromagnetic fields on serum lipids in workers of a power plant. Environ Sci Pollut Res Int. 2016 Feb; 23(3): 2495-504. PMID: 26423285
7. Chen Lin, Xinyuan Zhao, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu*, Xiangwei Gao*. Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress. Sci Rep. 2016 Feb 16; 6: 21133. (*Co-corresponding Authors) PMID: 26878911
8. Zhaopin Wang, Ying Fei, Hui Liu, Shuangshuang Zheng, Zheyuan Ding, Wen Jin, Yifeng Pan, Zexin Chen, Lijuan Wang, Guangdi Chen, Zhengping Xu, Yongjian Zhu, Yunxian Yu*. Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant. Int Arch Occup Environ Health. 2016 Jan; 89(1):33-42. PMID: 25808749

2015
9. Rongpan Bai, Chunhua Weng, Haojie Dong, Siqi Li, Guangdi Chen*, Zhengping Xu*. MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression. Int J Cancer. 2015 Nov 15; 137(10): 2310-22. (*Co-corresponding Authors) PMID: 25991585
10. Wen Sun, Liling Su, Yan Sheng, Ye Shen*, Guangdi Chen*. Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis? BMC Ophthalmology. 2015 Jul 26; 15: 84. (*Co-corresponding Authors) PMID: 26208492
11. Guohong Zhang, Yabin Cheng, Guangdi Chen, Yun Tang, Gholamreza Ardekani, Anand Rotte, Magdalena Martinka, Kevin McElwee, Xuezhu Xu, Qi Wang*, Youwen Zhou*. Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor prognosis. Oncotarget. 2015 Sep 8; 6(26): 23026-35. (*Co-corresponding Authors) PMID: 26246476
12. Jun Qian, Zhenfeng Zhu, Chris Wai Tung Leung, Wang Xi, Liling Su, Guangdi Chen, Anjun Qin, Ben Zhong Tang*, Sailing He*. Long-term two-photon neuroimaging with a photostable AIE luminogen. Biomed Opt Express. 2015 Mar 24; 6(4):1477-86. (*Co-corresponding Authors) PMID: 25909029
13. Yongdui Chen, Siqi Li, Liling Su, Jinghao Sheng, Wen Lv, Guangdi Chen*, Zhengping Xu*. Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis. J Neurol. 2015 Apr;262(4):814-22. (*Co-corresponding Authors) PMID: 25578179
14. Yabin Cheng, Jing Lu, Guangdi Chen, Gholamreza Safaee Ardekani, Anand Rotte, Magdalena Martinka, Xuezhu Xu, Kevin J. McElwee, Guohong Zhang*, Youwen Zhou*. Stage-specific prognostic biomarkers in melanoma. Oncotarget. 2015 Feb 28;6(6):4180-9. (*Co-corresponding Authors) PMID: 25784655
15. Kanghui Li, Xinyuan Zhao, Yixing Zhai, Guangdi Chen, El-Hang Lee, Sailing He*. A Study on the Biocompatibility of Surface-Modified Au/Ag Alloyed Nanobox Particles in Zebrafish in Terms of Mortality Rate, Hatch Rate and Imaging of Particle Distribution Behavior. Progress In Electromagnetics Research. 2015, 150, 89-96.

2014
16. Hui Liu, Guangdi Chen, Yifeng Pan, Zexin Chen, Wen Jin, Chuan Sun, Chunjing Chen, Xuanjun Dong, Kun Chen, Zhengping Xu, Shanchun Zhang, Yunxian Yu*. Occupational Electromagnetic Field Exposures Associated with Sleep Quality: A Cross-Sectional Study. PLoS One. 2014; 9(10): e110825. PMID: 25340654
17. Rongpan Bai, Yu Weng, Lilin Su, Mingjuan Jin, Zhengping Xu, Liqin Lu*, Guangdi Chen*. Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis. Asian Pac J Cancer Prev. 2014;15(23):10107-14. (*Co-corresponding Authors) PMID: 25556434
18. Wen Sun, Yan Sheng, Yu Weng, Chunxiao Xu, Susan EI Williams, Yutao Liu, Michael A Hauser, R. Rand Allingham, Mingjuan Jin, Guangdi Chen*. Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis. Int J Ophthalmol. 2014, 7(3): 550-556. PMID: 24967207
19. Jinghao Sheng, Liling Su, Zhengping Xu, Guangdi Chen*. Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease. Gene. 2014, 542(2):141-5. PMID: 24680777
20. Yingjun Li, Yingying Mao, Yang Zhang, Shaofang Cai, Guangdi Chen, Ye Ding, Jing Guo, Kun Chen, MingJuan Jin*. Alcohol drinking and upper aerodigestive tract cancer mortality: A systematic review and meta-analysis. Oral Oncol. 2014, 50(4): 269-75. PMID: 24405883

2013
21. Meibian Zhang, Xinglin Fang, Lifang Zhou, Liling Su, Jiajia Zheng,Minjuan Jin, Hua Zou*, Guangdi Chen*. Pesticide poisoning in Zhejiang, China: a retrospective analysis of adult cases registration by occupational disease surveillance and reporting systems from 2006 to 2010. BMJ Open 2013; 3: e003510. (*Co-corresponding Authors) PMID: 24270833
22. Zhenfeng Zhu, Xinyuan Zhao, Wei Qin, Guangdi Chen, Jun Qian, Zhengping Xu. Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging. Science China Chemistry. 2013, Sep; 56 (9): 1247-1252
23. Yabin Cheng, Guangdi Chen, Magdalena Martinka, Vincent Ho and Gang Li*. Prognostic Significance of Fbw7 in Human Melanoma and its Role in Cell Migration. J Invest Dermatol. 2013 Jun; 133 (7):1794-802. PMID: 23381582
24. Shanshan Xu, Guangdi Chen, Chunjing Chen, Chuan Sun, Dandan Zhang, Manuel Murbach, Niels Kuster, Qunli Zeng*, Zhengping Xu*. Cell Type-Dependent Induction of DNA Damage by 1800 MHz Radiofrequency Electromagnetic Fields Does Not Result in Significant Cellular Dysfunctions. PLoS One. 2013; 8 (1): e54906. (*Co-corresponding Authors). PMID: 23355902
25. Yibo Yu, Yu Weng, Jing Guo, Guangdi Chen*, Ke Yao*. Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis. PLoS One. 2013; 8 (1): e54037. (*Co-corresponding Authors). PMID: 23342067

2012
26. Hongjie Zhou, Guangdi Chen, Chunjing Chen, Yunxian Yu*,Zhengping Xu*. Association between Extremely Low-frequency Electromagnetic Fields Occupations and Amyotrophic Lateral Sclerosis: A Meta-analysis. PLoS One. 2012, 7 (11): e48354. (*Co-corresponding Authors). PMID: 23189129.
27. Guangdi Chen, Yabin Cheng, Yun Tang, Magda Martinka, Gang Li*. Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival. J Invest Dermatol. 2012 Nov; 132 (11): 2632-2641. PMID: 22673729
28. Guangdi Chen, Deqiang Lu, Huai Chiang, Dariusz Leszczynski D, Zhengping Xu*. Using model organism Saccharomyces cerevisiae to evaluate the effects of ELF-MF and RF-EMF exposure on global gene expression. Bioelectromagnetics. 2012 Oct; 33 (7): 550-560. PMID: 22487891.
29. Chunhua Weng, Haojie Dong, Guangdi Chen, Yixing Zhai, Rongpan Bai, Hu Hu, Linrong Lu, Zhengping Xu*. miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett. 2012 Oct; 323 (2): 171-179. PMID: 22531314
30. Yu Weng, Liqin Lu, Guorong Yuan, Jing Guo, Zhizhong Zhang, Xinyou Xie, Guangdi Chen*, Jun Zhang*. p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis. PLoS One. 2012 Sep; 7 (9): e45820. (*Co-corresponding Authors). PMID: 23029260.
31. Gang Wang*, Lingyan Zheng, Zhijian Yu, Guodong Liao, Liqin Lu, Rujun Xu, Zhongsheng Zhao, Guangdi Chen*. Increased cyclin-dependent kinase 6 expression in bladder cancer. Oncology Letters. 2012 Jul; 4 (1): 43-46. (*Co-corresponding Authors). PMID: 22807957.
32. Yu Weng, Jun Zhang, Xue Tang, Xinyou Xie*, Guangdi Chen*. Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. Leuk Lymphoma. 2012 Jul; 53 (7): 1345-1351. PMID: 22166040 (*Co-corresponding Authors)

2011
33. Guangdi Chen, Yabin Cheng, Zhizhong Zhang, Magdalena Martinka, Gang Li*. Prognostic significance of cytoplasmic p27 expression in human melanoma. Cancer Epidemiol Biomarkers Prev. 2011 Oct; 20(10): 2212-2221. PMID: 21828232
34. Zhizhong Zhang, Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Prognostic Significance of RUNX3 Expression in Human Melanoma. Cancer. 2011 Jun; 117 (12): 2719-2727. PMID: 21656750
35. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cytoplasmic Skp2 Expression Is Increased in Human Melanoma and Correlated with Patient Survival. Plos One. 2011 Feb; 6(2):e17578. PMID:21386910

2010
36. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cul1 expression is increased in early stages of human melanoma. Pigment Cell Melanoma Res. 2010 Aug; 23 (4): 572-574. PMID: 20518860
37. Guangdi Chen, Gang Li*. Increased Cul1 expression promotes melanoma cell proliferation through regulating p27 expression. Int J Oncol. 2010 Nov; 37(5):1339-1344. PMID: 20878082
38. Jin Bai, Yan Zhou, Guangdi Chen, JinyanZeng, Jingjing Ding, Yongfei Tan, Jianwei Zhou*, Gang Li*. Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. Human Pathology. 2010 Mar; 42(3): 375-383 PMID: 21190721
39. Guangdi Chen#, Yemin Wang#, Marco Garate, Jianwei Zhou, Gang Li*. The tumor suppressor ING3 is degraded by SCF (Skp2)-mediated ubiquitin-proteasome system. Oncogene. 2010 Mar; 29(10):1498-1508. (# Co-first authors) PMID: 19935701

2006-2009
40. Yibo Yu, Ke Yao*, Wei Wu, K Wang, Guangdi Chen, Deqiang Lu. Effects of exposure to 1.8 GHz radiofrequency field on the expression of Hsps and phosphorylation of MAPKs in human lens epithelial cells. Cell Res. 2008 Dec; 18(12):1233-1235. PMID: 19015670
41. Xiaoming Xing, Maode Lai*, Wolfgang Gartner, EnpingXu, Qiong Huang, Han Li, Guangdi Chen. Identification of differentially expressed proteins in colorectal cancer by proteomics: Down-regulation of secretagogin. Proteomics 2006 Jun; 6 (9): 2916-2923. PMID: 16586428.
42. Qunli Zeng#, Guangdi Chen#, Yu Weng, Lingli Wang, Huai Chiang, Deqiang Lu, ZhengpingXu*. Effects of Global System for Mobile Communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells. Proteomics 2006 Sep; 6 (17): 4732-4738. PMID: 16888767 (# Co-first authors)

中文文章
43. 魏晓霞, 许正平, 陈光弟. 移动电话射频电磁场暴露促动物肿瘤发展作用的研究进展. 中华劳动卫生职业病. 2016, 34(2): 155-158.
44. 赵新元, 方文攀，林晨，陈光弟. 极低频电磁场暴露与不良妊娠结局风险关联研究进展. 高电压技术. 2015, 41(4): 1383-1389.
45. 苏丽玲, 金明娟, 许正平, 陈光弟. 职业性极低频电磁场暴露与神经退行性疾病发病关联的研究进展. 中华流行病学杂志. 2014, 35(8): 965-969.
46. 叶怀庄, 余运贤, 周旭东, 陈光弟, 章军, 金力奋, 曾群力. 高等学校公共卫生实验教学示范中心建设与体会. 中国高等医学教育. 2013, 1: 60-61.
47. 陈春静, 徐珊珊, 陈光弟, 许正平. 移动电话射频电磁场的遗传毒性效应. 中华劳动卫生职业病杂志. 2013,31(4): 306-309.
48. 许正平, 陈光弟. 细胞水平电磁场生物学效应研究的发展方向. 中华劳动卫生职业病杂志. 2012, 30 (3): 161-162.
49. 陈光弟, 鲁德强, 姜槐, 许正平. 工频磁场对人乳腺癌细胞基因表达的影响. 浙江大学学报（医学版）. 2008, 37(1): 15-22.
50. 王玲莉, 陈光弟, 鲁德强, 姜槐, 许正平. 1800MHz射频电磁场对人乳腺癌细胞基因表达的影响. 中华预防医学杂志. 2006, 40 (4): 159-163.
51. 曾群力, 翁瑜, 陈光弟, 鲁德强, 姜槐, 许正平. 1800MHz射频电磁场对人乳腺癌细胞蛋白质表达的影响. 中华预防医学杂志. 2006, 40 (4): 153-158.
52. 陈光弟, 许正平, 姜槐. 移动电话射频电磁场与健康关系的体外试验研究. 中华预防医学杂志. 2005, 39 (4): 285-287.
53. 陈光弟, 许正平, 姜槐. 酵母的电磁场生物学效应研究进展. 中华劳动卫生与职业病杂志. 2005, 23 (3): 235-237.
54. 叶怀庄, 李莉, 王明达, 陈光弟. 抗衰老保健食品的抗氧化活性检测. 浙江预防医学. 2004,16 (9): 26, 49.