本人长期从事肿瘤发生发展分子机制及早期诊断标志物研究，主持和参与国家自然科学基金、863、省部级等课题20余项，开展表观遗传机制调控的新抑癌基因筛查,在国际上首次证明JPH3、CHAC2、PCDH17、PLCD1等是新的肿瘤抑制基因，通过对受累基因的深入研究，阐明了相关分子机制，寻找到肿瘤治疗的新靶点,对预后评估的有效指标以及作为外周血肿瘤表观标志物用于早期诊断，获得发明专利，具有极大的临床意义和社会效益。已发表论文60余篇，包括Blood、Oncogene、Autophagy、Theranostics、Journal of Pathology等高影响因子杂志，获浙江省自然科学奖一等奖，参与Elsevier出版社的经典表观遗传学参考书Handbook of Epigenetics第2版的撰写，完成Epigenetic Biomarkers章节。

学习和工作简历

1980年9月-1986年7月    杭州市学军中学

1986年9月-1991年7月    浙江医科大学临床医学专业，攻读学士学位

1991年9月-1994年7月    浙江医科大学组织胚胎学专业，攻读硕士学位

1995年8月-2000年9月    浙江医科大学组织胚胎学教研室

2000年10月-至今      浙江大学医学院附属邵逸夫医院生物医学研究（治疗）中心

2001年9月-2002年9月    香港大学玛丽医院内科系进修

2002年12月-2006年12月    香港大学医学院病理系，攻读博士学位

2010年3月-2010年4月    香港大学医学院病理系访问学者

研究和招生方向：

肿瘤发生发展分子机制及早期诊断标志物研究。

代表性论文(第一或通讯作者文章)

1.      Zhai S, Lin S, Lin Z, Xu J, Ji T, Chen K, Wu K, Liu H, Ying H, Fei W, Wang J, Fu G, Wang Y, Hu X^*, Cai X. eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. Gastric Cancer. 2020 May;23(3):483-96. (IF=7.088)

2.      Xu M, Zhu J, Liu S, Wang C, Shi Q, Kuang Y, Fang X, Hu X^*. FOXD3, frequently methylated in colorectal cancer, acts as a tumor suppressor and induces tumor cell apoptosis under ER stress via p53. Carcinogenesis. 2019 Nov 30:bgz198. (IF=4.603)

3.      He L, Fan X, Li Y, Chen M, Cui B, Chen G, Dai Y, Zhou D, Hu X^*, Lin H.  Overexpression of zinc finger protein 384 (ZNF 384), a poor prognostic predictor, promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma. Cell Death Dis. 2019 Jun 5;10(6):444. (IF=6.304)

4.      Chen J, Wang C, Fei W, Fang X, Hu X^*. Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival. Am J Cancer Res. 2019 Apr 1;9(4):752-64. (IF=5.177)

5.      Chen J, Fang X, Zhong P, Song Z, Hu X^*. N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction.RNA Biol. 2019 Aug;16(8):991-1000. (IF=5.35)

6.      Chen J, Wu Y, Zhang L, Fang X, Hu X^*. Evidence for calpains in cancer metastasis.J Cell Physiol. 2019 Jun;234(6):8233-40. (IF=5.546)

7.      Li X, Liu S, Fang X, He C, Hu X^*. The mechanisms of DIRAS family members in role of tumor suppressor.J Cell Physiol. 2019 May;234(5):5564-5577. (IF=5.546)

8.      Chen J, Liu S, Hu X^*. Long non-coding RNAs: crucial regulators of gastrointestinal cancer cell proliferation. Cell Death Discov. 2018 Apr 27;4:50. (IF=4.114)

9.      Fei W, Chen L, Chen J, Shi Q, Zhang L, Liu S, Li L, Zheng L, Hu X*. RBP4 and THBS2 are serum biomarkers for diagnosis of colorectal cancer. Oncotarget 2017 Sep 21; 8(54): 92254-64. (IF=5.168)

10.   Liu S, Fei W, Shi Q, Li Q, Kuang Y, Wang C, He C, Hu X*. CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response. Cell Death Dis 2017 Aug 24;8(8):e3009. (IF=6.304)

11.   Hu X*, Kuang Y, Li L, Tang H, Shi Q, Shu X, Zhang Y, Chan FK, Tao Q, He C. Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers. Theranostics 2017; 7(7): 2150-63. (IF=8.579)

12.   Liu X, Hu X, Kuang Y, Yan P, Li L, Li C, Tao Q, Cai X. BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade. Cancer Lett 2017 Jun 1; 395: 63-71. (IF=7.36)

13.   Fei W, Liu S, Hu X*. High FOXRED1 expression predicted good prognosis of colorectal cancer. Am J Cancer Res 2016 Nov 1; 6(11): 2722-8. (IF=5.177)

14.   Chen R, Zhu J, Dong Y, He C, Hu X*. Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells. Oncotarget 2015 Oct 20; 6(32): 32841-55. (IF=5.168)

15.   Zhu J, Chen R, Mo L, Tang H, Kuang Y, Fei W, He C, Hu X*. Expression of fibulin-1 predicted good prognosis in patients with colorectal cancer. Am J Transl Res 2015 Feb 15; 7(2): 339-47. (IF=3.375)

16.   Hu X, Xuan H, Du H, Jiang H, Huang J. Down-Regulation of CD9 by Methylation Decreased Bortezomib Sensitivity in Multiple Myeloma. PLoS One 2014 May 2; 9(5): e95765. (IF=2.74)

17.   Hu X, Sui X, Li L, Huang X, Rong R, Su X, Shi Q, Mo L, Shu X, Kuang Y, Tao Q, He C. Protocadherin 17 acts as a tumor suppressor inducing tumor cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers. J Pathol 2013 Jan; 229(1): 62-73. (IF=7.381)

18.   Sui XB, Jin LJ, Huang XF, Geng SM, He C, Hu X*. p53 Signaling and Autophagy in Cancer: A Revolutionized Strategy Could be Developed for Cancer Treatment. Autophagy. 2011 Jun;7(6):565-71.(IF=9.77)

19.   Hu X^#, Chen YW^#, Liang ACT, Au WY, Wong KY, Wan TSK, Wong MLY, Shen L, Chan KK, Guo T, Chu  KM, Tao Q, Chim CS, Loong F, Choi WWL, Lu L, So CC, Chan LC, Kwong YL, Liang RHS, Srivastava G. CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation. Blood. 2010 Mar; 115(2):2458-61. (IF=17.543)

20.   Hu X, Zhang FB, Fan YC, Shu XS, Wong AH, Zhou W, Shi QL, Tang HM, Fu L, Guan XY, Rha SY, Tao Q, He C. Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer.Oncogene. 2009 Jul;28(26):2466-75. (IF=7.971)