徐峰
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肺部感染分子发病机制及防治研究
医学博士(浙江大学),医学博士后(美国加州大学洛杉矶分校),教授,主任医师,博士生导师,浙江大学求是特聘医师。徐峰教授长期工作在临床一线,致力于感染性疾病的发病机制和防治研究。近年来承担了国家自然科学基金7项,军委重点项目1项及 10多项省部级课题。入选教育部新世纪优秀人才和浙江省卫生领军人才,是浙江省杰出青年基金获得者。以第一或通讯作者(含共同)在 AJRCCM,AJRCMB,Nano Today,ACS Nano,Cell Rep,J Infect Dis,J Immunol, J virol等权威期刊发表 SCI 论文 60 余篇,总 IF 520。参加制定 5 项国内感染性疾病指南,获批3项国家发明专利。担任国家自然科学基金委学科评审组专家,是 Bone Res,J Transl Med等多个 SCI 杂志的编委。
在三年新冠病毒疫情中,徐峰教授始终坚守临床一线,获得浙江省“抗击新冠肺炎疫情先进个人”和浙江大学“担当作为好支书”,率领科室获得“浙江省抗击新冠肺炎疫情先进集体”荣誉称号。此外,2015年徐峰教授赴非洲援助抗击埃博拉病毒,入选“全国援非抗埃先进事迹宣讲团”,获得“全国援非抗击埃博拉先进个人”和“第三届浙江省最美天使”荣誉。
学术任职:
担任国家自然科学基金委员会医学科学部学科评审组专家,中华医学会呼吸病学分会感染学组委员,中华医学会内科分会感染性疾病工作委员会委员,中国医药生物技术协会基因检测技术分会常务委员,中国医院协会健康医疗大数据应用管理专业委员会委员,浙江省医学会医学病毒学分会副主任委员,浙江省医学会热带病和寄生虫病学分会副主任委员,浙江省呼吸感染诊治联盟副主席,浙江省病原微生物实验室生物安全研究质量控制中心副主任,浙江省医师协会感染病学分会常务委员,浙江省医学会感染病学分会委员,浙江省医学会临床免疫分会常务委员等学术兼职。担任 Bone Res、J Transl Med和 Biomed等SCI杂志编委。是Ann Intern Med、Proc Natl Acad Sci USA、Signal Transduct Target Ther 等40多种SCI 期刊审稿人。
近年主持课题:
1. IFP35调控巨噬细胞铁死亡在金葡菌性肺损伤中的作用。项目编号:82241046。经费:72万元。起止时间:2023.1-2025.12。国家自然科学基金委员会科学部综合研究项目。
2. 感染性疾病的发病机制和防治研究。经费:100万元。起止时间:2023.1- 2027. 12。浙江省卫生与健康委员会浙江省卫生领军人才项目。
3. 耐药菌感染防治。经费:200万元。起止时间:2021.1-2023.12。军委后勤保障部重点项目。
4. N-Myc和STAT交互蛋白在甲型流感病毒性肺炎中的作用及调控机制。项目编号:81970004。经费:66万元。起止时间:2020.1-2023.12。国家自然科学基金委员会面上项目。
5. 肥大细胞在金黄色葡萄球菌肺炎中的作用及功能调控。项目编号:81770008。经费:69.6万元。起止时间:2018.1-2021.12。国家自然科学基金委员会面上项目。
6. 巨噬细胞蛋白酪氨酸磷酸酶SHP2调控肺部炎症和细菌清除的机制研究。项目编号:81570004。经费:72万元。起止时间:2016.1-2019.12。国家自然科学基金委员会面上项目。
7. RegIIIγ介导脂肪干细胞对金黄色葡萄菌所致急性肺损伤的保护作用及相关调控机制。项目编号:81370176。经费:85万元。起止时间:2014.1-2017.12。国家自然科学基金委员会面上项目。
8. 抗甲型流感病毒疫苗候选株的筛选和鉴定。项目编号:2014C03033。经费:90万元。起止时间:2015.1-2017.12 。浙江省科技厅重大与高发疾病防治技术专项。
9. 肺部感染与天然免疫机制。经费:40万元。起止时间:2017.1-2021.12。浙江省卫生与健康委员会浙江省卫生高层次创新人才项目。
10. 支气管扩张症微生物组学研究及基于群体感应的防治新方案。经费:500万元。起止时间:2022.1-2026.12。浙江大学医学院附属第二医院重大临床研究项目。
代表性论文:
1. Cen M, Ouyang W, Lin X, Du X, Hu H, Lu H, Zhang W, Xia J, Qin X*, Xu F*. FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.J Med Virol. 2023; 95(1): e28203. (IF: 20.693, JCR: Q1)
2. He T, Qiao Y, Yang Q, Chen J, Chen Y, Chen X, Hao Z, Lin M, Shao Z, Wu P*, Xu F*. NMI: a potential biomarker for tumor prognosis and immunotherapy. Front Pharmacol. 2022; 13: 1047463. (IF: 5.988, JCR: Q1)
3. Han Y, Bai X, Liu S, Zhu J, Zhang F, Xie L, Liu G, Jiang X, Zhang M, Huang Y, Wang J, Li D, Zhang H, He Y, He S, Xia Y, Xu X, Xu F*, Ma F*. XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity. J Virol. 2022; 96(17): e0077422. (IF: 6.549, JCR: Q2).
4. Zhang W, Zhou H, Cen M, Ouyang W, Chen J, Xia L, Lin X, Liu J, He T and Xu F*. N-myc and STAT interactor is a novel biomarker of severity in community-acquired pneumonia: a prospective study. Respir Res. 2022, 23(1): 253. (IF: 7.162, JCR: Q1).
5. He T, Hao Z, Lin M, Xin Z, Chen Y, Ouyang W, Yang Q, Chen X, Zhou H, Zhang W, Wu P*, Xu F*. Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation. Oncoimmunology,2022, 11(1): 2093054. (IF: 7.723, JCR: Q1).
6. Zhao J, Lu H, Xu D, Sun R, Fang C, Zhao Q, He C, Pan Y, Xu F*, Jiang T*. Neutrophil Membrane-coated Nanoparticles for Enhanced Nanosecond Pulsed Electric Field Treatment of Pancreatic Cancer. Int J Hyperther, 2021, 0393. (IF: 3.753, JCR: Q2).
7. Tu C, Lu H, Zhou T, Zhang W, Deng L, Cao W, Yang Z, Wang Z, Wu X, Ding J, Xu F*, Gao C*. Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties. Biomaterials, 2022, 286:121597. (IF: 15.304, JCR: Q1).
8.Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, Han Y, Duan L*, Cheng G*, Yang H*, Xu F*. Histone deacetylase 3 facilitates TNF α-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Cell Biosci, 2022;12(1):81. (IF: 9.584, JCR: Q1).
9. Hu H, Zhong D, Li W, Lin X, He J, Sun Y, Wu Y, Shi M, Chen X*, Xu F*, Zhou M*. Microalgae-based bioactive hydrogel loaded with quorum sensing inhibitor promotes infected wound healing. Nano Today, 2022, 42: 101368. (IF: 18.962, JCR: Q1).
10. Zhai Z, Ouyang W, Yao Y, Zhang Y, Zhang H, Xu F*, Gao C*. Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury. Bioact Mater, 2022;14: 430-42. (IF: 16.874, JCR: Q1).
11. Lu H, Tu C, Zhou T, Zhang W, Zhan Y, Ding J, Wu X, Yang Z, Cao W, Deng L, Gao C*, Xu F*. A ROS-scavenging hydrogel loaded with bacterial quorum sensing inhibitor hyperbranched poly-L-lysine promotes the wound scar-free healing of infected skin in vivo. Chem Eng J, 2022; 436: 135130. (IF: 16.744, JCR: Q1).
12. Yang L, Chen S, Zhao Q, Pan C, Peng L, Ha Y, Li L, Ruan J, Xia J, Yang H*, Xu F*, Cheng G*. Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription. Cell Rep, 2022;38:110302. (IF: 9.995, JCR: Q1).
13. Xia J, Xia L, Zhou H, Lin X, Xu F*. Empyema caused by Streptococcus constellatus: a case report and literature review.BMC Infect Dis. 2021;21(1):1267. (IF:3.667, JCR:Q3)
14. Cen M, Ouyang W, Zhang W, Yang L, Lin X, Dai M, Hu H, Tang H, Liu H, Xia J*, Xu F*. MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism. Redox Biol, 2021; 41: 101936. (IF: 10.787, JCR: Q1).
15. Lin X, He J, Li W, Qi Y, Hu H, Zhang D, Xu F*, Chen X*, Zhou M*. Lung-targeting lysostaphin microspheres for methicillin-resistant staphylococcus aureus pneumonia treatment and prevention. ACS Nano, 2021; 15(10): 16625-16641. (IF: 18.027, JCR: Q1).
16. Ouyang W, Cen M, Yang L, Zhang W, Xia J, Xu F*. NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 Through TRIM21. Am J Respir Cell Mol Biol. 2021; 65(1): 30-40. (IF: 7.748, JCR: Q1).
17. Du X, Zuo X, Meng F, Han C, Ouyang W, Han Y, Gu Y, Zhao X, Xu F*, Qin FX*. Direct inhibitory effect on viral entry of influenza A and SARS-CoV-2 viruses by azithromycin. Cell Prolif. 2021; 54(1): e12953. (IF: 8.755, JCR: Q1).
18. Ouyang W, Liu C, Pan Y, Han Y, Yang L, Xia J, Xu F*. SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection. Cell Prolif, 2020; 53(1): e12721. (IF: 8.755, JCR: Q1).
19. Sun X, Shang J, Wu A, Xia J*, Xu F*. Identification of dynamic signatures associated with smoking-related squamous cell lung cancer and chronic obstructive pulmonary disease. J Cell Mol Med, 2020, 24(2):1614-1625. (IF: 5.295, JCR: Q2).
20. Du X, Meng F, Peng D, Wang Z, Ouyang W, Han Y, Gu Y, Fan L, Jiang X, Xu F*, Qin X*. Non-canonical role of FBXO6 in regulating antiviral immunity. J Immunol. 2019; 203(4): 1012-1020. (IF: 5.426, JCR: Q2).
21. Liu C, Yang L, Han Y, Ouwang W, Wei Y, Xu F*. Mast cells participate in regulation of lung-gut axis during Staphylococcus aureus pneumonia. Cell Prolif, 2019; 52(2): e12565. (IF: 8.755, JCR: Q2).
22. Zhou H, Wang M, Smalley N, Schaefer A, Greenberg EP, Dandekar A*, Xu F*. Modulation of quorum sensing by glutathione in Pseudomonas aeruginosa. J Bacteriol, 2019; 201(9): JB.00685-18. (IF: 3.476, JCR: Q3).
23. Zhang Y, Li N, Wang M, Feng H, Xu F*. The interference from non-lethal graphene oxide on biofilm formation and the adaptive response of quorum sensing in bacteria. Env Sci Nano, 2018. 5(12): 2809-2818. (IF: 9.473, JCR: Q1).
24. Tang C, Liu C, Han Y, Guo Q, Ouyang W, Feng H, Wang M, Xu F*. Nontoxic carbon quantum dots/g-C3N4 for efficient photocatalytic inactivation of Staphylococcus aureus under visible light. Adv Healthc Mater, 2019; 8(10): e1801534. (IF: 11.092, JCR: Q1).
25. Han Y, Zhao R, Xu F*. Neutrophil-mediated delivery systems for nanotherapeutics. Small, 2018; 14(42): e1801674.(IF: 15.153, JCR: Q1).
26. Wu X, Wu P, Jiang X, Xu F*. CD8+ resident memory T cells and viral infection. Front Immunol, 2018; 9: 2093. (IF: 8.786, JCR: Q1).
27. Liu C, Ouyang W, Xia J, Sun X, Zhao L, Xu F*. Tumor necrosis factor-a is required for mast cell-mediated host immunity against cutaneous Staphylococcus aureus infection. J Infect Dis. 2018; 218(1): 64-74. (IF: 7.759, JCR: Q1).
28. Ouyang W, Zhou H, Liu C, Wang SW, Han Y, Xia JY, Xu F*. 25-Hydroxycholesterol protects against acute lung injury via targeting MD-2. J Cell Mol Med, 2018; 22(11): 5494-5503. (IF: 5.295, JCR: Q2).
专利:
1. NMI蛋白作为生物靶标在制备成人社区获得性肺炎严重程度及预后评估试剂盒的应用,2021, 中国,ZL202011310340.6
2. 碳量子点-类石墨相氮化碳光催化材料在制备杀菌促进皮肤疤痕愈合的药物中的应用,2021,中国,ZJ201811465046.5
3. 一种用于提高临床严重度评分预测效能的方法,2023,中国,ZJ2022109592875