周以侹， 浙江大学研究员，细胞信号传导、分化及代谢研究组组长。对含BCH结构域的BNIP-2蛋白家族进行了一系列开创性的工作。发现了这一家族蛋白成员在调控细胞分化、细胞形态、以及胞内运输中的重要作用。 有趣的是，该蛋白家族除了可以结合并调控小分子量G蛋白， 还可以结合小G蛋白的调控因子。研究结果发表于Journal of Biological Chemistry、Molecular Biology of the Cell、Oncogene等国际期刊。回国前在新加坡国立大学 医学院 (新国大-以色列希伯来大学宿主-病原相互作用项目) 任助理研究员。
2011年11月回国工作，和骆严教授、郑莉灵副教授组成癌症细胞代谢及信号转导研究团队。目前主要从事成肌细胞分化、细胞脂类代谢等方面的的机制研究。
本研究组正在招收博士及硕士研究生，欢迎有志于生命科学研究的学子报考。也欢迎对科研有兴趣的本科生来实验室实习。
发表文章：
Gupta AB, Wee LE, Zhou YT, Hortsch M, Low BC (2012) Cross-Species Analyses Identify the BNIP-2 and Cdc42GAP Homology (BCH) Domain as a Distinct Functional Subclass of the CRAL_TRIO/Sec14 Superfamily. PLoS ONE（影响因子：4.24）7(3): e33863. doi:10.1371/ journal.pone.0033863
Zhou, Y.T. Chew, L. L., Lin, S. C., and Low, B.C. (2010) The BNIP-2 and Cdc42GAP Homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-Activating Protein domain. Molecular Biology of the Cell（影响因子：5.35）, 15:3232-3246. (co-corresponding author)
Zhong, D., Zhang, J., Yang, S., Soh, U. J., Buschdorf, J. P., Zhou Y. T., Yang, D. and Low, B. C. (2009) The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration. Journal of Cell Science（影响因子：6.38）, 122:414-424.
Kang, J. S., Bae, G. U., Yi, M. J., Yang, Y. J., Oh, J. E., Takaesu, G., Zhou, Y. T., Low, B. C. and Krauss, R.S. (2008) A Cdo-Bnip-2- Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation. Journal of Cell Biology（影响因子：10.37）, 182:497-507.
B. J. Paul, Chew, L. L., Zhang, B., Cao, Q., Liang, F. Y., Liou, Y. C., Zhou, Y.T., and Low, B.C. (2006) Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. Journal of Cell Science （影响因子：6.38），119: 3337-3350.
Zhou, Y.T., Guy, G.R and Low, B.C. (2006) BNIP-Sa induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain. Oncogene（影响因子：7.18），25, 2393-2408.
Zhou, Y.T., Guy, G.R and Low, B.C. (2005) BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42 Binding motif within its BNIP-2 and Cdc42GAP Homology domain. Experimental Cell Research（影响因子：3.60）, 303:263-274.
Shang, X., Zhou, Y.T., Guy, G.R. and Low, B.C (2003) Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1. Journal of Biological Chemistry（影响因子：5.02）, 278: 45903-45914.
Zhou, Y.T., Soh, J.K., Shang, X., Guy, G.R and Low, B.C. (2002) The BNIP-2 and Cdc42GAP Homology/sec14p-like Domain of BNIP-S Is a Novel Apoptosis-inducing Sequence.Journal of Biological Chemistry（影响因子：5.02）, 277: 7483-7492.
