Profile

Professor Gu graduated from College of Medicine, Zhejiang University in 1982 and engaged in ophthalmological clinic, teaching and research for 25 years and have got the degrees of MD and PhD. Her research involves dioptrics, keratopathy and genetic ophthalmology. In the recent 5 years, she has brought up 10 master students, 4 of which work in the affiliated hospital of Zhejiang University after graduation and one works in National Eye Institute, USA now. At present, 3 students are studying for their doctorate supervised by Professor Gu.
As early as the beginning of the 1990s, Professor Gu believed that high myopia may impair the visual function of patients severely. The characteristics of the lesion are not merely limited to the scope of ametropia. The researches have by far involved in several medical branches. Some of them have demonstrated that there is abnormal microcirculation in the fundus.Thus, the hemorheological indicators in patients with high myopia were measured. Compared with the normal individuals, the hemorheological changes were assessed; then the degree of myopia ,ocular axial length and fundus change were examind. The influence of the hemorheological changes on the high myopia were analyzed. According to her research, the interrelationship between hemorheological changes and high myopia as well as the importance of the hemorheological changes for high myopia were discovered: there was a considerable increase of blood viscosity in the patients with high myopia; the lengthening of ocular axis and fundus lesions are a group of relevant pathological changes, and the hemorheological indicators were positively relevant to them.
Since the year 1998, she and associates pay more attention to the research about myopic refractive surgery. They compared regressive eyes with non-regressive eyes after in situ keratomileusis (LASIK) for myopia with regard to the time course of biomechanical changes of the cornea and discovered that refractive regression after LASIK might be mainly induced by corneal protrusion rather than central corneal thickening.
From 2002 to 2007, Professor Gu and associates collected 250 cases of genetic ocular diseases in total, the medical record, slit-lamp examination and family tree of which were documented in detail. The molecular-genetic analysis was made for 15 patients in 5 familys of corneal dystrophy and 20 sporadic patients. They found R555W、A546D、1665－1666insC mutations in CDGGI patients, R124H mutation in ACD patients, R124C、T538P mutations in LCDI patients and A546T、P501T in LCDIIIA patients. The 1665-1666insC is a new report.
For the future, Professor Gu and associates will study further on the molecular mechanism underlying genetic ocular diseases. Besides the corneal dystrophy, they will also study about the virulence gene or candidate gene and molecular mechanism of other ocular diseases, such as inborn cataract ,familial glaucoma and high myopia.