Profile

Dr. Hu Hu graduated from Zhejiang University School of medicine in 1996 and received his Ph. D. from the Karolinska Institute in Sweden in 2003. He then worked as a postdoctoral at Center for Molecular and Vascular Biology (CMVB), University of Leuven, Belgium during 2004-2005. He returned to Zhejiang University School of medicine and worked as an associate professor since 2006.
major research interests are the molecular mechanisms involved in platelet activation and thrombosis. We are also interested in elucidating the mechanisms underlying platelet-circulating cell interaction, which are of importance in facilitating the pathophysiological situations such as inflammation and tumor metastatsis.
1. Hu H, Daleskog M, Li N. Influences of fixatives on flow cytometric measurements of platelet P-selectin expression and fibrinogen binding. Thromb Res 2000; 100: 161-166.
2. Li N, Hu H, Linqvist M, Wikström Jonsson E, Goodall AH, Hjemdahl P. Platelet-leukocyte cross-talk in whole blood. Arterioscler Thromb Vasc Biol. 2000; 20: 2702-2708.
3. Hu H, Li N, Ekberg K, Johansson BL, Hjemdahl P. Insulin, but not proinsulin C-peptide, enhances platelet fibrinogen binding in vitro in Type 1 diabetes mellitus patients and healthy subjects. Thromb Res. 2002, 106:91-5.
4. Hu H, Hjemdahl P, Li N. Effects of insulin on platelet and leukocyte activity in whole blood. Thromb Res. 2002, 107:209-15.
5. Hu H, Zhang W, Li N. Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. J Thromb Haemost 2003, 2:1-8.
6. Hu H, Varon D, Hjemdahl P, Savion N, Schulman S, Li N. Platelet-leukocyte aggregation under shear stress: Differential involvement of selectins and integrins. Thromb Haemost 2003, 90: 679-87.
7. Li N, Hu H, Hjemdahl P. Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res. 2003;111:165-70.
8. Hu H, Li N, Yngen M, Österson C-G, Wallen NH, Hjemdahl P. Enhanced leukocyte-platelet cross-talk in type 1 diabetes mellitus: relationship to microangiopathy. J Thromb Haemost. 2004, 2: 58-64.
9. Yngen M, Ostenson CG, Hu H, Li N, Hjemdahl P, Wallen NH. Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation. Diabetologia. 2004, 47:537-40.
10. Hu H, Johansson B, Hjemdahl P, Li N. Exercise-induced platelet and leucocyte activation is not enhanced in well-controlled Type 1 diabetes, despite increased activity at rest. Diabetologia. 2004, 47:853-9.
11. Perneby C, Wallen NH, Hu H, Li N, Hjemdahl P. Prothrombotic responses to exercise are little influenced by clopidogrel treatment. Thromb Res. 2004, 114:235-43.
12. Hu H, Forslund M, Li N. Influence of extracellular calcium on single platelet activation as measured by whole blood flow cytometry. Thromb Res. 2005, 116:241-7.
13. Oury C, Daenens K, Hu H, Bryckaert M, Hoylaerts MF. ERK2 activation in arteriolar and venular murine thrombosis: role of platelet receptors GPIb and P2X1. J Thromb Haemost. 2006, 4(2):443-52.
14．Dong Z, Hu H，Chen W, Li z, Liu G, Yang J. Heat shock does not induce γH2AX foci formation but protects cells from N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity. Mutation Research. 2007, 629:40-8.
15. Razmara M, Hu H, Masquelier M, Li N. Glycoprotein IIb/IIIa blockade inhibits platelet aminophospholipid exposure by potentiating translocase and attenuating scramblase activity. Cell Mol Life Sci. 2007，64:999-1008.
16．Xu F, Wang F, Di M, Huang Q, Wang M, Hu H, Jin Y, Dong J, Lai M. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res. 2007， 13:5082-8.
17．Ruan W, Xu E, Xu F, Ma Y, Deng H, Huang Q, Lv B, Hu H, Lin J, Cui J, Di M, Dong J, Lai M. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Cancer Biol Ther. 2007，6:354-9.
18．Ruan WJ, Lin J, Xu EP, Xu FY, Ma Y, Deng H, Huang Q, Lv BJ, Hu H, Cui J, Di MJ, Dong JK, Lai MD. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. Zhejiang Univ Sci B. 2006，7:929-32.
19. Ma Y, Lu B, Ruan W, Wang H, Lin J, Hu H, Deng H, Huang Q, Lai M. Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. Exp Mol Pathol. 2008, 85:141-5.
20. Zou XH, Cai HX, Yin Z, Chen X, Jiang YZ, Hu H, Ouyang HW. A novel strategy incorporated the power of mesenchymal stem cells to allografts for segmental bone tissue engineering. Cell Transplant. 2009, 18:433-41. (co-corresponding author)
21. Chen X, Song XH, Yin Z, Zou XH, Wang LL, Hu H, Cao T, Zheng M, Ouyang HW. Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors. Stem Cells. 2009, 27:1276-87.
22. Xu F, Xu J, Lou Z, Di M, Wang F, Hu H, Lai M. Micropapillary Component in Colorectal Carcinoma is Associated With Lymph Node Metastasis in T1 and T2 Stages and Decreased Survival Time in TNM Stages I and II. Am J Surg Pathol. 2009, 33:1287-92.
23. Hu H, Hoylaerts MF. The P2X1 ion channel in platelet function. Platelets 2010, 21:153-66.
24. Huang ZS, Zeng C, Zhu L, Jiang L, Li N, Hu H. Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of PI3K. J Thromb Haemost. 2010, 8:1383-93.（corresponding author)
25.Hu XS, Du C, Zeng CL, Yao L, Zhang F, Wang K, Chen J, Li N, Hu H. Systemic evaluation of platelet and leukocyte activation and interaction in a rat model of pulmonary arterial hypertension. Cardiology 2010, 117(1):44-53. （corresponding author)
26. Hu H, Zhu L, Huang ZS, Ji Q, Chatterjee M, Zhang W, Li N. Platelets selectively enhance lymphocyte adhesion and infiltration into arterial thrombus. Thromb Haemost. 2010, 104(6):1184-92.