Profile

Hefeng Huang M.D., Professor of OB/GY

Education:
1982, Zhejiang Medical University, M.D.
1997-1998, The University of Cincinnatti, USA, Postdoctorial fellow

Position:
Chair professor of Zhejiang University
Chief physician of obstetrics & gynecology, with specialty in the fields of reproductive medicine and genetics.
President of Women's Hospital, School of Medicine, Zhejiang University, China.
Director of the Key Laboratory of Reproductive Genetics, Ministry of Education, China,
Director of the Reproductive Medicine Center of Zhejiang Province,
Director of Institute of OB/GY & Family Plan of Zhejiang University
Visiting professor of University of Adelaide, Australia

Other position:
Deputy-chairman of Chinese Society of Reproductive Medicine
Deputy-chairman of Chinese Association of Integrative Medicine of Obstetrics and Gynecology.
Chief Scientist of the National Basic Research Program of China (973 project)
Chief Scientist of the National "Twelfth Five-Year" Plan for Science & Technology Support Project of China.

Awards:
The Young and Middle-aged Expert with outstanding contribution, Ministry of Health,China.
2010, The National Science and Technology Progress of China,  Second-Level Prize.
2011, The National Science and Technology Progress of China,  Second-Level Prize.  

Members of editorial board:
Endocrinology, Fertility & Sterility, Reproductive Biology & Endocrinology, Asia Journal of Andrology and Journal of Ovarian Research.

Research interest:
Basic and clinical research in reproductive medicine, gynecological endocrinology and reproductive genetics.

Selected publications （*Corresponding author):
1.Ruan YC, Guo JH, Liu X, Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H*, Zhou WL*, Chan HC*: Activation of the epithelial Na(+) channel triggers prostaglandin E(2) release and production required for embryo implantation. Nat Med 2012 Jul;18(7):1112-7.  
2.Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF*: Functions of water channels in male and female reproductive systems. Mol Aspects Med 2012，Oct-Dec; 33(5-6): 676-90.
3.Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Peter CK Leung, Sheng JZ*, Huang HF*: Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia. Diabetes 2012, 61:1133-1142.
4.Lu YC, Chen H, Fok KL, Tsang LL, Yu MK, Zhang XH, Chen J, Jiang X, Chung YW, Ma AC, Leung AY, Huang HF*, Chan HC*: CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development. Cell Res. 2012 Oct;22(10):1453-1466.
5.Yin LJ, Zhang Y, Lv PP, He WH, Wu YT, Liu AX, Ding GL, Dong MY, Qu F, Xu CM, Zhu XM, Huang HF*: Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Med 2012 Mar 13;10:26.
6.Liu XM, Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ, Huang H*. Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure. J Clin Endocrinol Metab 2012 Oct; 97(10):3672-83.
7.Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang HF*, Chan HC*: Impaired CFTR-Dependent Amplification of FSH-Stimulated Estrogen Production in Cystic Fibrosis and PCOS. J Clin Endocrinol Metab 2012;97:923-32.
8.Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ*, Huang HF*: Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation. J Clin Endocrinol Metab 2012, 97:543-553.
9.Qu F, Wang FF, Yin R, Ding GL, El-Prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Peter CK Leung, Sheng JZ, Huang HF*: A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med (Berl) 2012 Aug; 90(8):911-23.
10.Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF*: Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod 2012, 27:1421-1430.
11.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi SA, Zhang D, He RH, Liu AX, Wang TT, Leung PCK, Sheng JZ*, Huang HF*: Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma. J Clin Endocrinol Metab 2011, 96:E1399-E1408.
12.Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PCK, Huang HF*: Sustained Endoplasmic Reticulum Stress as a Cofactor of Oxidative Stress in Decidual Cells from Patients with Early Pregnancy Loss. J Clin Endocrinol Metab 2011, 96:E493-E497.
13.Yu Zhang, Yan-Ling Zhang, Chun Feng, Yan-Ting Wu, Ai-Xia Liu, Jian-Zhong Sheng, Jie Cai, He-Feng Huang*. Comparative proteomic analysis of human placenta derived from assisted reproductive technology. Proteomics 2008, 8(20), 4344–4356.
14.Li MG, Ding GL, Chen XJ, Lu XP, Dong LJ, Dong MY, Yang XF Lu XE, Huang HF*. Association of Serum and Follicular Fluid Leptin Concentrations with Granulosa Cell Phosphorylated Signal Transducer and Activator of Transcription 3 Expression in Fertile Patients with Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2007 Dec;92(12):4771-6.
15.Huang HF*, He RH, Sun CC, Zhang Y, Meng QX, Ma YY. Function of Aquaporins in Female & Male Reproductive Systems. Hum Reprod Update. 2006 Nov-Dec;12(6):785-95.