Profile

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General information

Name Jian Huang
Current position: Professor; Attending surgeon
Telephone/ Fax: 0086 571 87315009 Email: hjys@zju.edu.cn
Working unit : Dept of Oncology, Cancer Institute
2nd Affiliated Hosoital , Zhejiang University, School of Medicine
Unit address: 88 Jiefang Rd, Hangzhou 310009 ,Zhejiang Province,China
Field of specialisation: Clinical Oncology; Cancer research

Career

10/2001-present Professor, Zhejiang University, School of Medicine,China.
09/1997-10/2001 Associate Professor/consultant, Zhejiang University, School of Medicine, China.
09/1992-10/1997 Lecturer/Fellow, Zhejiang University, School of Medicine,China.
07/1986-10/1992 Assitant/Resident, Zhejiang University, School of Medicine,China.

Education

09/1992-06/1996 Ph.D,MD, Zhejiang University, School of Medicine,China.
09/1981-07/1986 BSc, Zhejiang University, School of Medicine,China.

10/1994-10/1995 Visiting Scholar, MRC Human Genetics Unit, Western General Hospital,Edinburgh ,UK
(supported by Sino-British frendship scholarship)
11/2003-03/2004 Senior Visiting Scholar, University of Michigan
(supported by Bao’s scholarship)

Research Subject:

My main research interests focus on translational research of cancer as a clinical scientist. My group not only continues efforts to treat cancer patients by surgery-based modality (clinical research) for gastrointestinal,breast and thyroid cancers , and also do molecular research for cancer using specimens from the tumor tissues and blood. In the area of cancer research, that includes identification and biological features of cancer stem cell; novel biomarker discovery from plasma using techniques including high-throughput mass spectrometry (plasma proteomics) for the prediction of cancer susceptibility, recurrence and survivability; and molecular target determination of Chinese medicinal herbs for antitumor . All were funded by national or provincial research grants.

Related publications( * corresponding author)
1） Wang K, Xu J, Zhang J, Huang J*.Prognostic role of CD133 expression in colorectal cancer: a meta-analysis. BMC Cancer. 2012 ;12(1):573. (IF=3.01)
2） Wang K ,Zhang T ,Liu LN,Wang XL,Wu P;Chen ZG,Ni C,Zhang JS,Hu FQ, Huang J*. Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells. Int J Nanomedicine. 2012;7:4487-97. (IF=3.130)
3） Ni C, Huang J*.Dynamic regulation of cancer stem cells and clinical challenges. Clinical And Translational Oncology. 2012 online
4） Ye J, Wu D, Shen J, Wu P, Ni C, Chen J, Zhao J, Zhang T, Wang X, Huang J*. Enrichment of colorectal cancer stem cells through epithelial-mesenchymal transition via CDH1 knockdown. Mol Med Reports. 2012;6(3):507-12
5） Luo C, Zhong HJ, Zhu LM, Wu XG, Ying JE, Wang XH, Lü WX, Xu Q, Zhu YL, Huang J*. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep.2012,39(5):5459-64.
6） Ke Wang, Lina Liu, Tao Zhang, Yong-liang Zhu, Fuming Qiu, Xian-guo Wu, Xiao lei Wang, Fu-qiang Hu, Jian Huang*.Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. Int J Nanomedicine.2011:6 3207–3218. (IF=4.975)
7） Wang Y, Zhu Y, Qiu F, Chen Z, Zhang T, Zhen S, Huang J*.Activation of Akt and MAPK pathways enhances the tumourigenicity of CD133+ primary colon cancer cells . Carcinogenesis.2010,31(8):1376-80.（IF=5.4）
8） Qiu FM, Yu JK, Chen YD, Jin QF, Sui MH, Huang J*.Mining Novel Biomarkers for Prognosis of Gastric Cancer with Serum Proteomics. J Exp Clin Canc Res. 2009 Sep 9;28:126.
9) Zhang M, Huang J, Xie X, Holman CD. Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. Int J Cancer 2009, 124(6):1404-8. (IF 4.7)
10) Zhu Y, Jiang Q, Lou X, Ji X, Wen Z, Wu J, Tao H, Jiang T, He W, Wang C, Du Q, Zheng S, Mao J, Huang J.MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells.PLoS One. 2012;7(4):e35147. (IF 4.6)
11). Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson JK, Markowitz SD, Morin P, Kinzler KW, Vogelstein B, Dunlop MG. APC mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci U S A. 1996;20;93(17):9049-54

Book chapter
Colorectal cancer : from clinical practice to basic research (2006; Chinese)