Profile

CURRICULUM VITAE

Gonghui Li , M.D.;Ph.D.
Department of Urology , Sir Run Run Shaw Hospital
3 Qingchun East Road , Hangzhou, P.R.China, 310016
Tel: 86-571-86002147 (O) 86-13588708507(cell)
Email: ligonghui1970@hotmail.com


Education:
2005-2007 University of Rochester, USA. Post-doctor
2002-2005 Zhejiang University, Hangzhou, China, Ph.D
1997-2000 Zhejiang University, Hangzhou, China, MS
1988-1993 Zhejiang Medical University, Hangzhou, China, BS

Clinical Experience:
2004 to present Attending of Urology , Sir Run Run Shaw Hospital , Hangzhou, China
2002-2003 Fellow of Urology , Sir Run Run Shaw Hospital , Hangzhou, China
1999-2001 Residency of Urology, Sir Run Run Shaw Hospital, Hangzhou, China
1994-1998 General Surgery Resident Training, Sir Run Run Shaw Hospital, Hangzhou, China
1992-1993 Internship, the First Affiliated Hospital of Zhejiang Medical University, Hangzhou, China

Research Experience:
--- Take charge 7 research projects on prostatic disease.
--- Participated in more than 10 research projects.
--- more than 60 articles published

Research Skills:
---Skillful use of basic molecular biology technical skills such as cell culture, gene recombination,Western Blot ,ChIP , EMSA and RT-PCR.
---Well trained in small animal surgery.
---able to knock-out selected gene using siRNA or shRNA.

Organizations, Honors and Awards:
---Secretary, postgraduate degree committee of Urology, Medical College of Zhejiang University,2000 to present.
---Science and Technology Innovation award given by Health Bureau of Zhejiang Province, 2002.
--- Outstanding young surgeon of Hangzhou, 2001.
---Pao Yu-Kong and Pao Zhao-Long Scholarship for Chinese Students Studying Abroad, 2003.
---First prize of postgraduate students award of Zhejiang University, 1998.

Research Projects (selected):
1.The role testicular orphan receptor 4 (TR4) in radiotherapy of prostate cancer. (Principal Investigator , funded by national natural science foundation of China.)
2.The animal and clinical study of the effect of COX-2 inhibitors on the delay of the prostate cancer progression from androgen dependent to androgen independent stage (Principal Investigator, funded by Health Bureau of Zhejiang Province.)
3.Gene therapy for prostate cancer by silencing androgen receptor and hTERT gene using siRNA. (Ph.D. degree program.)
4.The effects on prostate cancer by blocking expression of androgen receptor and hTERT with antisense oligonucleotide . (Principal Investigator , funded by Sir Run Run Shaw Hospital.)
5.Mesurement of irrigating fluid absorption during transurethral resection of prostate. (Principal Investigator, funded by Health Bureau of Zhejiang Province.)
6.Study on the effect of extremely low frequency magnetic field on connexin43 of testis by laser scanning confocal microscope .( Principal Investigator, funded by Analysis Foundation of Zhejiang Province)
7.Development of connexin43 of upper urinary tract and its abnormal change in patients with congenital hydronephrosis. ( Principal Investigator , funded by Zhejiang University.)
8.Application of laparoscopy for renal disease.
(Co-investigator , funded by Euducation Bureau of Zhejiang Province.)
9. Study of hemastasis methods during laparoscopic partial nephrectomy. ( Co-investigator , funded by Health Bureau of Zhejiang Province.)

Published Articles(selected):
1.Gonghui Li , Yi-Fen Lee, Su Liu, Yi Cai, Shaozhen Xie, Ning-Chun Liu, Bo-Ying Bao, Zhaodian Chen, and Chawnshang Chang. Oxidative Stress Stimulates TR4 Orphan Receptor through Forkhead Transcription Factor FOXO3a. Endocrinology. 2008,149(7):3490-9.
2.Li GH, Li XD, Cheng S, Chen ZD. A large intrascrotal calculus. Asian J Androl.2005,7(1):103-105.
3.Yi Cai, Yi-fen Lee, Gonghui Li (Co-first author), Su Liu, Bo-Ying Bao and Chawnshang Chang. A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. Internation Journal of Cancer. Int J Cancer. 2008 Jul 1;123(1):195-201.
4.Niu Y, Yeh S, Miyamoto H, Li G, Altuwaijri S, Yuan J, Han R, Ma T, Kuo HC, Chang C. Tissue prostate-specific antigen facilitates refractory prostate tumor progression via enhancing ARA70-regulated androgen receptor transactivation. Cancer Res. 2008 Sep 1;68(17):7110-9.
5.Kuang-Hsiang Chuang, Saleh Altuwaijri, Gonghui Li , Jiann-Jyh Lai, Chin-Yi Chu, Kuo-Pao Lai, Hung-Yun Lin, Jong-Wei Hsu, Peter Keng, Ming-Chi Wu, and Chawnshang Chang. Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J Exp Med. 2009 May 11;206(5):1181-99.
6.Li XD, Cheng S, Rui XF, Li GH, Chen YB, Wu Hy. Transurethral prostatectomy using Vista bipolar radiofrequency system: comparison with conventional transurethral resection of the prostate. Arch Androl. 2006 52(4):293-8.
7.X.-D.Li, H.-Y.Wu, G.-H.Li. The risk factors of erectile dysfunction following tranurethral resection of prstate. Andrology Update,2007,1(1):94-98.
8.Li GH, Zhang ZG, Li XD. Quantitative study on the effect of finasteride on intraoperative bleeding and irrigating fluid absorption during transurethral resection of prostate. J UROL 2002, 169(4),suppl:1458.
9.Li Gonghui, et al . Perioperative hypotention during transurethral resection of prostate . Journal of Zhejiang University(Medical Sciences) , 2002,31(3):206. (paper in Chinese)
10.Yu Damin, Li Gonghui, et al . Laparoscopic adrenectomy :38 cases report. Journal of Zhejiang University(Medical Sciences), 2003,32(5):305. (paper in Chinese)
11.Yu Damin, Zhang Dahong, Li Gonghui, et al . Laparoscopic ureterolithotomy. Journal of Zhejiang University(Medical Sciences), 2002,31(4):305. (paper in Chinese)
12.Li Gonghui, et al . Hypothermia during transurethral resection of prostate. Chinese Journal of Urology, 2002,23(11):675. (paper in Chinese)
13.Li Gonghui, et al . Clinical application and evaluation of viedo laparoscopic surgery in urology. Journal of Zhejiang University(Medical Sciences) , 2001,30(2):82. (paper in Chinese)
14.Li Gonghui, et al .Randomized controlled study on sparfloxacin and minocycline in treatment of male nongonococcal urethritis. Chinese Journal of Antibiotics, 2001,26(5):385. (paper in Chinese)
15.Li Gonghui, et al . Multiple factors analysis of perioperative hypotension during transurethral resection of prostate. Zhejiang Medical Journal , 2001,23(10):632 (paper in Chinese)
16.Li Gonghui, et al . Application of D-J tube in patiens with upper urinary tract disease . Zhejiang Medical Journal , 2001,23(1):53. (paper in Chinese)
17.Li Gonghui, et al . Retrograde cathterization of D-J tube under cystocsopy. Journal of Zhejiang Medical University,1998,27(1): 36. (paper in Chinese)
18.Li Gonghui, et al . Penile keratoacanthoma: case report . Journal of Zhejiang University(Medical Sciences) , 2000,29(6):244
19.Li Gonghui, et al . Prostatic duct carcinoma: case report . Journal of Zhejiang Medical University,1995,24(3): 131. (paper in Chinese)