Profile

Name:Ji-Cheng Li
Title: Director of Cell Biology Institute
Head of the Department of Anatomy and Cell Biology
Designation: Professor
Education: Postgraduate
Major: Cell biology, Histology and Embryology
Respective Faculty: Basic Medical Sciences, School of Medicine
Research field: Molecular Biology and Molecular Genetics
Phone: 0571-88208088
E-mail: lijichen@zju.edu.cn
Personal Home Page:
Personal Introduction (contains the following):
Currently, level 9 professor of Zhejiang University, among first master and doctoral students supervisor. As a project leader, chaired 8 National Natural Science Foundation and 2 National Science Training base projects. Published 53 SCI papers (top journal 21 articles) including 42 as a first and corresponding author (top journal 16 articles); first and corresponding author of other 84 papers.
Memberships of Academic Community and Society:
Executive Director of Cell Biology in China, Deputy Secretary General, President of Medical Cell Biology branch, Chinese Medical Association, Vice Chairman of Cell Biology branch, member of Genetics branch; Chairman, Zhejiang Society for Cell Biology, Vice Director of Association for Instrumental Analysis, Zhejiang Province; Council member of European Lymphatic Society, Member of the German Anatomical Society, Member of the New York Academy of Sciences, Member of American Association Advancement Science (AAAS).
Associate Editor of an American journal “The Anatomical Record” in China, Member of Editorial Board of journals such as Neuroembryology and Aging, Molecular Cell Biology, Cell Biology, Anatomy, Basic and Clinical Medical Sciences, Technology Bulletin, Zhejiang University (medical sciences) and Immuohistochemistry.
Academic and Research Experience:
Chaired 8 projects of the National Natural Science Foundation
Chaired 1 key project of the National Pharmaceutical Administration
Chaired 1 doctoral fund
Chaired 1 Ministry of Health and Zhejiang Province Special Talents Fund
Chaired 1 major special sub-topic of Science and Technology, Ministry of Science
Presided over 1 major issue in Zhejiang Province
Subject expertise and research directions:
1. Genetics research on lymphatic metastasis related genes
2. Natural drug-induced tumor cell apoptosis and related gene mutation
3. Lungs Tuberculosis proteomics
4. Lymphatic regulatory factors and signal transduction
5. Molecular genetics of Hirschsprung disease
Main Research Projects:
1. Major projects in the Ministry of Science and Technology: Integrated Treatment of tuberculosis research program, 2008ZX10503
2. Diagnosis and clinical application on serum protein spectrum based model of tuberculosis, a major science and technology project in Zhejiang Province 2009
3. RET gene in Hirschsprung/'s disease /"risk haplotype/" in the region of unknown function of SNPS loci. Natural Science Foundation of Zhejiang Province, NO.Y2080430
4. Educational Reform and Innovation in teaching Cell Biology, the National Natural Science Foundation, No.J0910001
Selected Papers:
1. Li M, Chen F, Liu CP; Li DM, Li X, Wang C, Li JC. Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line. Life Sci. 2010, 86（1）10－16.
2. Cui-Ping Liu, Xin-Gang Li, Jin-Tu Lou, YunXue, Chun-Fen Luo, Xue-Wu Zhou, Fei-Chen, Xiang Li, Meng Li, Ji-Cheng Li. Association analysis of the PHOX2B gene with Hirschsprung disease in the Han Chinese population of Southeastern China. Journal of Pediatric Surgery 2009;44(9):1805-1811
3. Dun-Hong, Hai-Xiao Chen,Yun Xue, Dong-Mei Li, Xiao-Chen Wan, Renshan Ge, Ji-Cheng Li. Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells. Journal of Steroid Biochemistry & Molecular Biology 2009;116:86–92
4. Marong Fang, Zhiying Hu, Yan Li, Ji-Cheng Li, David T Yew. Nestin positive cells in the retina and spinal cord of the sturgeon after hypoxia. International Journal of Neuroscience 2009;119-460
5. Lei Jiang, Yangchao Chen, Chu-yan Chan, Xin Wang, Lin Lind, Ming-liang He, Marie C.M. Line, David T. Yew, Joseph J.Y. Sung, Ji-Cheng Li*, Hsiang-fu Kung*. Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells. Cancer Letters, 2009;274:101-108.
6. Yingyu Ma, Liang Wu, Cuiping Liu, Liqian Xu, Dongmei Li and Ji-Cheng Li. The correlation of genetic instability of PINX1 gene to clinico- pathological features of gastric cancer in the Chinese population. J Cancer Res Clin Oncol. 2009, 135(3):431-7
7. Ping Wang, Li-Li Chen, Hui Yan, Ji-Cheng Li. Trichosanthin suppresses Hela cell proliferation through inhibition of the PKC/MAPK signaling pathway. Cell Biol Toxicol 2009；25：479－488
8. Xiao-Chen Wan ,Cui-Ping Liu ,Meng Li ,Dun Hong, Dong-Mei Li a, Hai-Xiao Chen, Ji-Cheng Li. Staphylococcal enterotoxin C injection in combination with ascorbic acid promotes the differentiation of bone marrow-derived mesenchymal stem cells into osteoblasts In vitro. Biochemical and Biophysical Research Communications 2008；373：488–492.
9. Cuiping Liu, Lei Jin, Hui Li, Jintu Lou, Chunfen Luo, Xuewu Zhou ,Ji-Cheng Li. RET polymorphisms and the risk of Hirschsprung’s disease in a Chinese population. J Hum Genet 2008；53:825–833.
10. Dun Hong, Hai-Xiao Chen, Ren-Shan Ge, Ji-Cheng Li. The biological roles of extracellular and intracytoplasmic glucocorticoids in skeletal cells. Journal of Steroid Biochemistry & Molecular Biology 2008; 111:164–170
11. Yue-Qin Yang, Liang Wu, Jin-Xing Chen, Jian-Zhong Sun, Meng Li, Dong-Mei Li, Hai-Ying Lu, Zhi-Hong Su, Xin-Qiu Lin, Ji-Cheng Li. Relationship between nm23H1 genetic instability andclinical pathological characteristics in Chinese digestivesystem cancer patients. World J Gastroenterol 2008; 14(32):
12. Zeran Yang, Ji-Cheng Li. Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3β signaling in endothelial cells. Life Sciences 2008;82:512-518.
13. Lanhai Lu, Ji-Cheng Li, Yonghong Zhu, Ying T Mak, David T Tew. H2O2-induced changes in astrocytic cultures from control and rapidly aging strains of mouse. International Journal of Neuroscience 2008;118:1239-1250
14. Lü, L.H., Li, J.C., Yew, D.T., Rudd, J.A., Mak, Y.T. Oxidative stress on the astrocytes in culture derived from a senescence accelerated mouse strain. Neurochem.Int. 2008;52:282-289
15. Zan Shen, Zhen Fan Yang, Yi Gao, Ji-Cheng Li, Hai-Xiao Chen, Ching Chiu Liu, Ronnie TP Poon, Sheung Tat Fan, John M Luk, Kong Hung Sze, Tsai Ping Li, Ren Bao Gan, Ming Liang He, Hsiang Fu Kung, Marie CM Lin. The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinoma. Cancer Res 2008;68(2):404-414.
16. Yan-Yuan Li, Ji-Cheng Li.A Cell Signal Transduction Mechanism for Nitric Oxide Regulating Lymphatic Stomata and its Draining Capability. Anat Rec 2008;291(2):216-223.
Honors and Awards:
In 1997 received the /"151 Talents Project/" (the first echelon), Zhejiang Province. In 1999 received special government allowances issued by the State Council. In 2001 received Outstanding Young Scientist Award, Zhejiang Province.
As a prize winner, won first prize award by China Natural Science College (2001). Won 4 second (1998, 2000, 2002, 2004) and 2 third (1993, 2006) Zhejiang Science and Technology Progress Awards
Edited or Supervised Books and Teaching Materials:
Editor In Chief, /"Histology and Embryology,/" seventh edition, Ministry of Health five-year plan system; Editor In Chief, /"Histology and Embryology Experimental Technology,/" Ministry of Health; Associate Editor, /"Histology and Embryology,/" second edition, eight year plan system; Editor In Chief, /"Histology and Embryology/", Peking University Press; Editor In Chief, /"Histology and Embryology,/" Editor In Chief, /"Medical Cell Biology/", Zhejiang University Press.