Profile

PhD, Associate Professor of Dept. Respirology and the internal medicine of teaching and researching section of The Second Affiliated Hospital of Zhejiang University College of Medicine, Research associate of Zhejiang university institute of respiratory diseases. Professor Li have been a clinical physician and researcher for 20 years, and have been trained and practiced in the fields of respiratory diseases, critical care medicine, lung function, respiratory laboratory, and fibro-bronchoscopy, immunology, molecule biology. Research focus: Molecular and inflammatory mechanisms and early treatment and prevention of asthma and chronic obstructive pulmonary disease (COPD), and have published nine papers in SCI journal such as Allergy, Biochemical and Biophysical Research Communications, Chinese Medical Journal, took charge of two projects funded by National Natural Science Foundation of China (NSFC) and Zhejiang Provincial Science & Technology Department respectively, and as a main member got a project supported by the 863 programme of Ministry of Science and Technology of China, and 973 program supported by Chinese governmet.
Address: 88 # Jiefang Road, Hangzhou, China Postcode: 310009,
Contact: Tel: 0571-87783729/88208007
　　 E-mail: liwenzjhz0408@163.com
Website: www.googlehuxi.cn
Publications：
1. Yan F, Li W（co-author），Zhang S，et al. P. aeruginosa Lipopolysaccharide-induced MUC5AC Expression via TLR4-PKC-Duox1 Cascades. Am J Respir Cell Mol Biol. Submitted.
2. Fugui Yan, Li W,（co-author）, Hirofumi Jono, et al. Reactive oxygen species regulate Pseudomonas aeruginosa Lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-signaling pathways in human airway epithelial cells. BBRC. 2008, 366(2):513-9.
3. Shen H, Huang H, Wang J, Ye S, Li W, Wang K, Zhang G, Wang P. Neonatal vaccination with Bacillus Calmette-Guerin elicits long-term protection in mouse allergic responses. Allergy. 2008, 63: 555-563.
4. Ben SQ, Li XB, Xu F, Xu WH, Li W, Wu ZQ, Huang HQ, Shi GZ, Shen HH. Treatment with anti-CCR3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model. Allergy. 2008, 63:1164-1176
5. Zhang GS, Xu ZH, Cui W, Zhou F, Xia Y, Li W, Li LB, Shen HH. A case with lethal endobronchial lymphoma presenting with respiratory failure requiring intubation and mechanical ventilation. Chin Med J (Engl). 2008, 121(3) :280-282.
6. Li W, Shen HH. Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice. Chin Med J (Engl). 2007,120(1) :5-11.
7. Li Wen, Shen HH. Effect of cigarette smoke extract on lipopolysaccha-ride-activated mitogen-activated protein kinase signal transduction pathway in cultured cells. Chin Med J (Engl). 2007,120(12):1075-81.
8. Wang K, Shen HH, Li W, Huang HQ. Human C-C chemokine receptor 3 monoclonal antibody inhibits pulmonary inflammation in allergic mice. Acta Pharmacol Sin. 2007，28(11):1791-6.
9. Shen HH, Yoshida H, Yan FG, Li W, Xu F, Huang HQ, Jono H, Li JD. Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae. BBRC 2007, 365(4):795-800.
10. Li W, Xu YJ, Zhang Z. Influences of interleukin 4 and interleukin 6 on the amiloride-sensitive Na+ channel current in human bronchial epithelium cells of COPD patients. Chinese Journal of Pathophysiology. 2006, 22(2) :318-321.
11. Li W, Xu YJ, Zhang Z. Influence of lipopolysaccharide on the expression of Toll-like receptor 4 in human bronchial epithelium cell in patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2006,27(7) : 448-451.
12. Li W, Xu YJ, Zhang Z. Zhang Zheng-xiang. Activity of matrix metalloproteinase in airway epithelial cells of COPD patients. J Huazhong Univ Sci Technolog Med Sci. 2005, 25(2): 151-154.
13. Li W, Xu YJ, Zhang Z. Detection of the mRNA level of the subunits of amiloride-sensitive Na+ channel in human bronchial epithelium cells from patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 2004, 27(8):533-536.