Profile

Dr. Xiao-Ming Li is a “Changjiang” Scholar Distinguished Professor and PI at Institute of Neuroscience of Zhejiang University School of Medicine and the professor at the university of Toronto. He earned the M.D. from First Military Medical University in 1996 and Ph.D. in 2003. He worked as a Resident Physician, Attending Physician at Hospital of Chinese People's Liberation Army during 1996-2004. He got his postdoctoral training at Dept. of Neurology, Medical College of Georgia, USA during 2005-2007. After that, he worded as an Assistant Research Scientist at Institute of Molecular Medicine and Genetics，Medical College of Georgia, USA from 2007-2008. In August, 2008, he joined Zhejiang University. Now he is the Executive Vice-Dean of Zhejiang University School of Medicine, the Executive Director of Institute of Neuroscience of Zhejiang University and the Director of the Brain Center of Affiliated Sir Run Run Shaw Hospital, also the General Secretary of Zhejiang Society for Neuroscience.

Prof. Li’ main research interest is to understand the molecular mechanisms underlying the formation, maintenance and regulation of synapses and neural circuits, in identifying targets to develop therapeutic strategies for treating neuropsychiatric disorders including schizophrenia, autism, and epilepsy. He has made important achievements in the field of the development and molecular regulation of synapses and circuits, especially in the pathogenesis of schizophrenia and epilepsy. His representative papers have been published on“Nature Neuroscience”,“Cell Research”,“elife”,“Journal of Neuroscience”, “Cerebral cortex” and so on. His research supports include Distinguished Young Scholars, National Natural Science Foundation of China; National Key Basic Research Developing Project, 973 project and so on.

Representative publications

Corresponding author

1.Dong P, Wang H, Shen XF, Jiang P, Zhu XT, Li Y, Gao JH, Lin S, Huang Y,      He XB, Xu FQ, Duan SM, Lian H, Wang H, Chen JD, Li XM*. Thalamic reticular      nucleus circuits for flight behavior. Nature Neurosci. Accepted. (2019)

2.Shen CJ, Zheng D, Li KX, Xie Y, Fu JY, Yu XD, Pan HQ, Li JR, Duan Sm,      Hu HL, Li XM*. Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic      afferents to nucleus accumbens modulate depressive behavior. Nature      Medicine，25(2):337-34.（2019）

3.Li Y, Li CY, Xi W, Jin S, Wu ZH, Jiang P, Dong P, He XB, Xu FQ, Duan      SM, Zhou YD, Li XM*. Rostral and Caudal Ventral Tegmental Area      GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid      Dependence. Neuron., 101(4):748-761. (2019)

4.Yang JM, Shen CJ, Chen XJ, Kong Y, Liu YS, Li XW, Chen Z, Gao TM, Li XM*. Erbb4 Deficits in Chandelier      Cells in the Medial Prefrontal Cortex Confer Cognitive Dysfunctions: Implications      for Schizophrenia. Cerebral Cortex., 22.doi: 10.1093(2018)

5.Cao SX, Zhang Y, Hu XY, Hong B, Sun P, He HY, Geng HY, Bao AM, Duan      SM, Yang JM, Gao TM, Lian H*, Li XM*. ErbB4 deletion in      noradrenergic neurons in the locus coeruleus induces mania-like behavior      via elevated catecholamines. eLife（2018）

6.Geng HY, Jing Z, Yang JM, Li Y, Wang N, Ye M, Chen XJ, Lian H and Li XM*. Erbb4 Deletion from      Medium Spiny Neurons of the Nucleus Accumbens Core Induces      Schizophrenia-Like Behaviors via Elevated GABAA Receptor α1 Subunit Expression. Journal      of Neuroscience, 37 (31) : 7450-7464 (2017)

7. Zhao CY, Zhang J, Li KX, Yang JM, Yu HM, Duan SM, Jiang KW, Li XM, β-catenin regulates membrane potential in muscle cells through regulation of α2 subunit of Na-K-ATPase. European Journal of Neuroscience, 40(1),2216-24(2014). 

8. Wu HJ, Liu YJ, Li HQ, Chen Q, Dou Y, Lou HF, Ho MS, Li XM, Duan SM, Gao ZH, Analysis of microglial migration by a micropipette assay. Nature protocols, 9,491–500(2014). 

9. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan SM, Yu YQ. selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Current Biology, 24(6), 693-8(2014). 

10. Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1pyramidal neuronal death after transient global ischemia. Cell Death and Diseases, 27,5:e1541(2014). 

11. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM. A novelsize-based sorting mechanism of pinocytic luminal cargoes in microglia. Journal of Neuroscience, 33(21),4282-4293.3(2013). 

12. Li, H.Q., Chen, C., Dou, Y., Wu, H.J., Liu, Y.J., Lou, H.F., Zhang, J.M., Li XM, Wang H., Duan S., P2Y4 receptor-mediated macropinocytosis contributes to Aß-induced self-uptake by microglia. Molecular Cell Biology, 33(21),4282-4293(2013). 

13. Dou Y, Wu HJ, Li HQ, Qin S, Wang YE, Li J, Lou HF, Chen Z, Li XM, Luo QM, Duan SM. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Research, 22(6),1022-33.62(2012). 

14. Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH. Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway. Journal of Neuroscience, 32(35),11919-29(2012). 

15. Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiology Disease, 48(1), 20-6(2012).

Co-author

1. Zhao CY, Zhang J, Li KX, Yang JM, Yu HM, Duan SM, Jiang KW, Li XM, β-catenin regulates membrane potential in muscle cells through regulation of α2 subunit of Na-K-ATPase. European Journal of Neuroscience, 40(1),2216-24(2014).

2. Wu HJ, Liu YJ, Li HQ, Chen Q, Dou Y, Lou HF, Ho MS, Li XM, Duan SM, Gao ZH, Analysis of microglial migration by a micropipette assay. Nature protocols, 9,491–500(2014).

3. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan SM, Yu YQ. selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Current Biology, 24(6), 693-8(2014).

4. Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1pyramidal neuronal death after transient global ischemia. Cell Death and Diseases, 27,5:e1541(2014).

5. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM. A novelsize-based sorting mechanism of pinocytic luminal cargoes in microglia. Journal of Neuroscience, 33(21),4282-4293.3(2013).

6. Li, H.Q., Chen, C., Dou, Y., Wu, H.J., Liu, Y.J., Lou, H.F., Zhang, J.M., Li XM, Wang H., Duan S., P2Y4 receptor-mediated macropinocytosis contributes to Aß-induced self-uptake by microglia. Molecular Cell Biology, 33(21),4282-4293(2013).

7. Dou Y, Wu HJ, Li HQ, Qin S, Wang YE, Li J, Lou HF, Chen Z, Li XM, Luo QM, Duan SM. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Research, 22(6),1022-33.62(2012).

8. Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH. Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway. Journal of Neuroscience, 32(35),11919-29(2012).

9. Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiology Disease, 48(1), 20-6(2012).