Profile

Li Yong-Quan, Ph.D，Professor

Qiushi-Distinguished Prof. of Zhejiang University

Prof.of Microbial Molecurlar Biology and Microbial Pharmaceutics

Director of Institute of Pharmaceutical Biotechnology, Zhejiang University

Director of Zhejiang Provincial Key Lab for Microbial Biochemistry and  Metabolic Engineering

Room 401#, Biological experimental center，Zhejiang University, 866# Yuhangtang Road, Hangzhou310058, China

086-571-88206632 (O), 88208569(Fax),lyq@zju.edu.cn

Brief introduction

Dr. Li Yong-Quan is director of institute of pharmaceutical biotechnology in Zhejiang University, China, and a professor of Microbial Molecurlar Biology and Microbial Pharmaceutics. He earned his PhD degree from Zhejiang University, China in 2013. His research is interested in secondary metabolic regulatory mechanism, microbial synthetic biology and microbial pharmaceutics. He presided over a number of important projects in recent years, such as project of 863 Program, Key project of NSFC, Key Project for National New Drug Development, etc., and has published more than 90 research articles. He has completed the development of several microbiological drugs, such as tacrolimus, natamycin, daptomycin and other microbial, and support cooperation enterprise for a number of new drug certificate.

 Experience

2016.03- Present Director of Institute of Pharmaceutical Biotechnology

2012-01- Present  Qiushi-Distinguished Prof. of Zhejiang University

2009.12- Present Director of Zhejiang Province Key Lab of Microbial Biochemistry and Metabolic Engineering,

2006.03-2015.12  Director of Institute of Biochemistry, Zhejiang University

2010.09-2010.11  Visiting Scholar, Cornal University, USA

2007.01-2007.03   Visiting Scholar, University of Wisconsin-Madison, USA

2001.05.-2002.07  Visiting Scholar, University of Minnesota, USA

1999.01-2003.06  Ph.D. Bioengineering, Zhejiang University,China

1998.09-2001.12   Associate Professor, College of Life Science, Zhejiang University,China.

1996.01-1998.08   Associate Professor, College of Life Science, Hangzhou University,China.

1992.04-1995.12    Lecturer, College of Life Science, Hangzhou University,China

1989.09-1992.07   M.S. Biochemical Engineering, Zhejiang University,China

Responsible main projects in recent years

[1] Key project of the National Natural Science Foundation（No31730002），Temporal regulatory mechanisms of the regulatory pathway for secondary metabolic process in Streptomyces,  2016.01-2020.12。

[2] Key international cooperation project of the National Natural Science Foundation（No31520103901），The molecular mechanism of cryptic gene cluster activation for secondary metabolites in Streptomyces, 2016.01-2020.12。

[3] General  project of the National Natural Science Foundation, Molecular mechanism of acyl transferase in type I polyketide synthase（No 31470212）,2015.01-2018.12。

[4] Subproject of 973 Program （National Basic Research Program of China），Analysis and optimization of drug synthesis pathway（No2012CB721005），2012.01-2016.12

[5] project of 863 Program，Research and application of high efficient synthesis of microbial drugs（No2012AA02A706），2012.11-2015.12。

[6]  National Key Project for New Drug Development，The development of new drug daptomycin against multidrug-resistant bacteria（No2011ZX09202-101-11）, 2011.01-2013.12。

[7] Subproject of National Key technology R and D program，Research and development of a new type of food preservative Natamycin（No 2011BAD23B05-2）,2011.01-2015.12。

[8]  General  project of the National Natural Science Foundation, Regulation mechanism of sigma factor in Streptomyces（No 31070040 ）, 2011.01-2013.12。

[9] general  project of the National Natural Science Foundation，Molecular mechanism of protein transduction mediated by Streptomyces SRP pathway（No30870033）,2009.01-2011.12。

Selective Publication

（More than and 90 papers were published in international journals in this field）

[1] Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou，Xin-Hang Jiang, Xu-Ming Mao，Shui-Ping Liu，Wen-Jun Guan, Yong-Quan Li，Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10, Molecular Microbiology，2017， 103(4), 713–728

[2] Xu-Ming Mao, Shuai Luo, Ri-Cheng Zhou, Feng Wang, Pin Yu, Ning Sun, Xiao-Xia Chen, Yi Tang and Yong-Quan Li*，Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator AtrA，Journal of Biological Chemistry, 2015, 290（12）:7992–8001.

[3]  Xu-Ming Mao, Wei-Hong Feng, Ning Sun, Zhan Zhou and Yong-Quan Li*. Dual Positive Feedback Regulation of Protein Degradation of an ECF (extra-cytoplasmic function) Sigma Factor for Cell Differentiation in Streptomyces coelicolor, Journal of  Biological Chemistry, 2013,288（43）：31217-31228

[4] Peng-Hui Yuan, Ri-Cheng Zhou, Xuepeng Chen, Shuai Luo, Feng Wang, Xu-Ming Mao*,Yong-Quan Li*, DepR1, aTetR-family transcriptional regulator, positively regulates daptomycin production in an industrial producer Streptomyces roseosporusSW0702, Applied and Environmental Microbiology, 2016，82(6):1898-1905

[5] Yue-Yue Wang, Xiao-Sheng Zhang, Hong-Dou Luo, Ni-Ni Ren, Xin-Hang Jiang,Hui Jiang, Yong-Quan Li, Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network, Scientific Reports,  2016 Apr 7;6:24255.

[6] Hui Jiang, Yue-Yue Wang, Wei-Ming Fan, Xin-Hang Jiang,Wen-Jun Guan,* and Yong-Quan Li*. Improvement of Natamycin Production by Engineering of Phosphopanteth Transferases in Streptomyces chattanoogensis L10, Applied and Environmental Microbiology, 2013, 79（11）：3346-3354

[7] Yi-Ling Du,Xue-Ling Shen,Pin Yu,Lin-Quan Bai,and Yong-Quan Li*. Gamma-Butyrolactone Regulatory System of Streptomyces chattanoogensis Links Nutrient Utilization,Metabolism and Developmental Programme, Applied and Environmental Microbiology, 2011,77（23）：8415-8426

[8] Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang , Yong-Quan Li*,  WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology, 2014,80(22):6879-6887; 

[9] Guo, Yuanyang; Li, Han; Zhou, zhenxing; Mao, Xu-Ming; Tang, Yi; Chen, Xin; Jiang, Xin-Hang; Liu, Yu; Jiang, Hui; Li, Yong-Quan*. Identification and Biosynthetic Characterization of Natural Aromatic Azoxy Products from Streptomyces chattanoogensis L10,Organic Letters, 2015, 17:6114−6117

[10] Shui-Ping Liu，Pin Yu, Peng-Hui Yuan，Zhen-Xing Zhou,Qing-Ting Bu, Xu-Ming Mao and Yong-Quan Li^*, Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10, Applied Microbiology and Biotechnology, 2015,99(6):2715-2726;

[11] Zhen-Xing Zhou,Qing-Qing Xu,Qing-Ting Bu,Shui-Ping Liu, Pin Yu, Yong-Quan Li*, Transcriptome-guided identification of SprA as a pleiotropic regulator in Streptomyces chattanoogensis , Applied Microbiology and Biotechnology, 2015，99 (3):1287-1298;

[12] Zhen-Hong Zhu, Han Li, Pin Yu，Yuan-Yang Guo, Shuai Luo, Zhong-Bin Chen, Xu-Ming Mao, Wen-Jun Guan, Yong-Quan Li*, SlnR is a positive pathway-specific regulator for salinomycin, Appl Microbiol Biotechnol, 2016,100(23), DOI 10.1007/s00253-016-7918-5

[13] Zhenxing Zhou,Qingqing Xu,Qingting Bu,Yuanyang Guo,Shuiping Liu,Yu Liu,Yiling Du,Yongquan Li*, Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster inStreptomyces chattanoogensis, ChemBioChem, 2015, 16(3):496-502

[14] Xu-Ming Mao, Zhi-Hao Sun, Bi-Rong Liang, Zhi-Bin Wang, Fang-Liang Huang, Yong-Quan Li*. Positive feedback regulation of StgR expression for secondary metabolism in Streptomyces coelicolor, Journal of Bacteriology, 2013,195（9）：2072-2078.

[15] Yi-Ling Du, Shan-Zhen Li, Zhan Zhou, Shi-Fei Chen, Wei-Min Fan, Yong-Quan Li*.The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis. Microbiology-sgm, 2011, 157: 1300–1311

[16] Jiang H, Wang YY, Guo YY, Shen JJ, Zhang XS, Luo HD, Ren NN, Jiang XH, Li YQ*. An Acyltransferase Domain of FK506 Polyketide Synthase Recognizing Both an Acyl Carrier Protein and Coenzyme A As Acyl Donors To Transfer Allylmalonyl and Ethylmalonyl Units. FEBS J. 2015, 282: 2527–2539