Profile

Education: 2002 Bachelor (Ecology, the College of life sciences, Sichuan University, P.R.China) 2007 Ph.D. (Cell biology, the College of life sciences, Peking University, PR.China) Professional record: 2007-2009 Postdoctoral fellow, the School of Medicine, Yale University, U.S.A 2009-2010 Postdoctoral fellow, M.D.Anderson Cancer Center, U.S.A 2010-2015 Associate professor, Life sciences institute, Zhejiang University, P.R.China Research Interests: Both exogenous and endogenous factors, such as ionizing radiation, ultraviolet rays and reactive oxygen species can cause DNA damage, which occur at a rate of 1000-1,000,000 molecular lesions per cell per day. Unrepaired or misrepaired lesions in crucial genes will eventually lead to genome instability and tumorigensis. To cope with the life threatening crisis of DNA damage, cell has evolved several DNA damage surveillance mechanisms to detect and propagate the initial DNA damage signal, leading to checkpoint activation, DNA repair and apoptosis. My overall goal is to understand the molecular mechanisms underlying genome instability and tumorigenesis. Publications: First author/Corresponding author: 1. Liu, T., Ghosal, G., Yuan, J., Chen, J., and Huang, J. (2010). FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329, 693-696. 2. Wan, L.*, Han, J.*, Liu, T.*, Dong, S., and Huang, J. (2013). SPIDR connects the BLM-TopoIIIalpha-RMI1/2 complex with homologous recombination repair. PNAS 110, 10646-10651(* are co-first authors) 3. Liu, T., Wan, L., Wu, Y., Chen, J., and Huang, J. (2011). hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem286, 41758-41766. 4. Liu, T., Chen, H., Kim, H., Huen, M.S., Chen, J., and Huang, J. (2012). RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair 11, 131-138. 5. Liu, T. and Huang, J. (2014). Quality control of homologous recombination. Cell Mol Life Sci. 71 (19): 3779-97 (Corresponding author) 6. Liu,T., Huang,J., and Chen, J. (2010). RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair9, 1241-1248. 7. Liu, T., and Feng, X.H. (2010). Regulation of TGF-beta signalling by protein phosphatases. Biochem J 430, 191-198. 8. Wan, T.*, Liu, T.*, Zhang, H., Tang, S., and Min, W. (2010). AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J Biol Chem 285, 3750-3757.（* are co-first authors） 9. Huang, J.*, Liu, T.*, Xu, L.G., Chen, D., and Zhai, Z., and Shu, H.B. (2005). SIKE is an IKKepsilon/TBK1-associated suppressor of TLR-and virus-triggered IRF-3 activation pathways. EMBO J 24, 4018-4028.（* are co-first authors） Others: 1. Dong, S., Han, J., Chen, H., Liu, T., Huen, MS., Yang, Y., Guo, C., Huang, J. (2014). The human SRCAP chromatin remodeling complex promotes DNA-End resection. Current Biology. 24(18):2097-2110. 2. Han, J., Liu, T., Huen, MS., Hu, L., Chen, Z., Huang, J. (2014). SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 205(6), 811-27. 3. Feng, Y., Wu, H., Xu, Y., Zhang, Z., Liu, T., Lin, X., and Feng, X.H. (2014) Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor- signaling. J Biol Chem 289(4):2072-83. 4. Wan, L., Lou, J., Xia, Y., Su, B., Liu, T., Cui, J., Sun, Y., Lou, H., and Huang, J. (2013). hPrimpol1/CCDC111 is a human DNA primase- polymerase required for the maintenance of genome integrity. EMBO Report 14, 1104-1112.