Profile

Dr. Wei Liu was appointed a Professor of Cell Biology at Zhejiang University School of Medicine in 2007. Dr. Liu earned his M.D. from the Fourth Military Medical University in 1987, and received his Ph.D.from Nagoya University (Japan) in 1998. His postdoctoral research in Department of Immunology,Nagoya University was immediately followed by an appointment as Assistant Professor at Aichi Medical University (Japan) in 1999. He then worked in Jennifer Lippincott-Schwartz's lab at NIH as a visiting fellow and research fellow from 2001-2007.

Wei's group is interested in the molecular mechanisms underlying the structure and function of endomembrane system. By analyzing protein and organelle dynamics, they are relating the endomembranes to important cell physiological/pathological processes. Currently, they focus on the molecular cell mechanisms and functions of autophagy, the lysosome-dependent cell degradation pathway. 

Selected publications:

Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, Wong CC, Su H, Zhou T, Xia H, Liu W* (2017) mTORC1 phosphorylates acetyltransferase p300 to regulate autophagy and lipogenesis. Mol Cell 68:323-335.

Su H, Yang F, Wang T, Shen Q, Huang J, Peng C, Zhang Y, Wan W, Wong CC, Sun Q, Wang F, Zhou T, Liu W* (2017) VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy. Mol Cell 67(6):907-921.

Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, Wang L, Zhou T, Liu W* (2016) TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. Autophagy 12:1118-1128.

Chang C, Su H, Zhang D, Wang Y, Shen Q, Liu B, Huang R, Zhou T, Peng C, Wong CC, Shen HM, Lippincott-Schwartz J, Liu W* (2015) AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Mol Cell 60:930-940. 

Huang R, Xu Y, Wan W, Shou X, Qian J, You Z, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, Liu W* (2015) Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol Cell 57:456-466.

Feng W, Chang C, Luo D, Su H, Yu S, Hua W, Chen Z, Hu H, Liu W* (2014) Dissection of autophagy in human platelets. Autophagy 10:642-651.

Liu B, Fang MD, Hu Y, Huang BS, Li N, Chuang CM, Huang R, Xu X, Yang ZG, Chen Z, Liu W* (2014) Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy 10:1-15, 2014.

Mao L, Li N, Guo Y, Xu X, Gao L, Xu Y, Zhou L, Liu W* (2013) AMPK phosphorylates GBF1 for mitotic Golgi disassembly. J Cell Sci 126:1498-1505.

Li N, Zhang L, Chen L, Feng W, Xu Y, Chen F, Liu X, Chen Z, Liu W* (2012) MxA inhibits hepatitis B virus replication by interaction with core protein HBcAg. Hepatology 56:803-811.

Guo Y, Chang C, Huang R, Liu B, Bao L, Liu W* (2012) AP1 is essential for generation of autophagosomes from trans-Golgi network. J Cell Sci 125:1706-1715.

Xiang WQ, Feng WF, Ke W, Sun Z, Chen Z, Liu W* (2011) Hepatitis B Virus X Protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway. J Hepatol 54:26-33.