Profile

Profile

Zhuoxian Meng is a tenure-track professor and PhD mentor at the Department of Pathology and Pathophysiology. Prior to joining ZJU, he worked as a Postdoc Research Fellow and Research Investigator at the University of Michigan. His laboratory is investigating the transcriptional networks and signaling pathways that control energy metabolism in both physiological and pathological states. His long-term career goal is to elucidate the molecular basis of obesity and diabetes, and to find new clues for the therapy of these disorders.

Education

2004−2009    Ph.D. in Biochemistry and Molecular Biology, Nanjing Medical

                      University, China

1999−2004    M.D. in Clinical Medicine,Nanjing Medical University, China

Professional Experience

2016−      Professor, Principal Investigator, (研究员)

                      School of Basic Medical Sciences, Zhejiang University

                      Research Focus: Molecular mechanisms of obesity and diabetes

2014−2015       Research Investigator,

                      Life Sciences Institute, University of Michigan

                      Research Focus: Role of chromatin remodeling cofactors in metabolic control and diseases

2009−2014    Postdoctoral Research Fellow,

                      Life Sciences Institute, University of Michigan

 Research Focus: Regulation of energy metabolism by SWI/SNF      chromatin remodeling cofactors

2004−2009    Graduate Student,

                     Department of Biochemistry and Molecular Biology, Nanjing Medical University

Research Focus: Roles of inflammation and glucolipotoxicity in pancreatic β Cell failure in diabetes

Professional Membership

2015−         Member, Chinese American Diabetes Association

2015−         Member, American Diabetes Association

2013−         Member, American Heart Association

2012−         Member, American Physiological Society

Peer-Review Service

2015−         Plos One

2014−         Journal of Biological Rhythms

2014−         Scientific Reports

2013−         Endocrinology

2013−         Diabetologia

Representative publications

1.      Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis. Cell Reports. 13: 1-12. *co-corresponding author

2.      Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD (2014) The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine.20:1436-43. 

3.      Meng ZX, Wang L, Xiao Y, Lin JD (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes. 63:1533-45.

4.      Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD (2013) Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine. 19: 640-5.

5.      Meng ZX, Wang GX, Lin JD (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation.125: 2815-7.

6.      Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X (2012) Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 55: 1733-44.

7.      Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology. 150: 5284-93.

8.      Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52: 125-35.

9.      Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia. 49: 2959-68.