Profile

Education12/2008  Ph.D. in Physics Electronics, University of Science and Technology of China  (USTC), Hefei, China. 07/2003  B.S. in Applied Physics, University of Science and Technology of China, Hefei, China, graduated with the highest GPA (3.9/4.0) and honor (Guo Mo Ruo Scholarship Award). Research Interests My research interests lie in the image guidance in the interventional surgery and radiation therapy.

Positions and Employment 01/2014-Pres  Research Professor , Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China • Advanced conebeam CT imaging guidance in surgery and radiation therapy 08/2013-12/2013  Adjunct Assistant Professor , Nuclear & Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA • Teaching：Medical Health Physics (MP6401) 2013 Fall 01/2013- 12/2013  Research Scientist (equivalent to Research Assistant Professor in Medical School) , Nuclear & Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA • Compressed sensing based iterative CT reconstruction. • Low-dose quantitative cone-beam CT imaging. • Cone-beam CT based adaptive radiation therapy. 10/2009- 01/2013 Postdoctoral Fellow, Nuclear & Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology, Atlanta, GA• Construction of a table-top cone-beam CT system. The system provides a multi-functional platform for development of advanced imaging technologies to provide better treatment guidance in modern radiation therapy. Specifically, the system has the full functionality of an x-ray cone-beam CT, which is widely used in the current image-guide and adaptive radiation therapy. • Implement two effective algorithms to correct scatter contamination in modern cone-beam CT scanners. (supported by NIH 1R21EB012700-01A1) • Conceptual design of a Compton scatter imaging system on the cone-beam CT platform. • Compressed-sensing based treatment planning. • Clinical rotation at Emory University Hospital. • Three patent pending/disclosures were filed on these inventions.09/2003- 06/2009 Research Assistant ,University of Science and Technology of China, Hefei, China• Design and implement two portable instruments for radionuclide half-life measurement and dose monitoring of environmental radiation. • Invent an electron density and energy measurement system for ionized gas jet. 09/2007- 09/2008 Visiting Student , University of Saskatchewan, Saskatoon, Canada• Design and implement a low-energy x-ray detection system for STOR-M fusion device. 09/2003- 06/2006 Teaching Assistant , University of Science and Technology of China, Hefei, China • For 4 courses of undergraduate level and 1 course of graduate level. • A variety of courses: classic mechanics, nuclear physics, analog and digital circuit design, computer programming language, etc.

Goal: to design and fabricate a snake-like robotics for in-body radiation therapy with on-board cone-beam CT guidance.    Role: Co-PI. In charge of the on-board cone-beam CT design, including hardware construction and reconstruction algorithm implementations. 2011 NIH 1R21EB012700-01A1    Role: Co-investigator. Design an effective scatter correction algorithm for on-board   cone-beam CT.

Selected Awards and Honors 2012 IEEE NSS/MIC Trainee Grant 2007 Samsung Summer Camp Travel Grant 2005 Excellent Student Counselor Award 2004 Guanghua Scholarship Award 2003 Guo Mo Ruo Scholarship Award (The most prestigious scholarship in USTC) 2003 Zhang Zong Zhi Scholarship Award 2003 “Best Bachelor Thesis” Award, USTC, P.R.China 2003 “Best Bachelor Graduate” Honor, USTC, P.R.China 2003 Eighth “Challenge Cup” Campus Recognition Award in the National Undergraduate Scientific Innovation and Creation Contest 2002 Samsung Scholarship Award Patents and Invention Disclosures Issued 1. Lei Zhu and Tianye Niu, X-ray Compton scatter imaging on volumetric CT systems. US Utility Patent, Serial No: 13/565,337, File date: 08/02/2012. 2. Lei Zhu and Tianye Niu, Scatter correction for conebeam CT using planning MDCT images. US Utility Patent, Serial No: 13/088,134, File date: 04/15/2011. Pending 1. Tianye Niu, A fast image-domain scatter correction for conebeam CT. CN Invention Patent, Serial No: 201410757244.4, File date: 12/10/2014. 2. Tianye Niu, Adaptive iterative scatter correction for conebeam CT imaging. CN Invention Patent, Serial No: 201410583570.8, File date: 10/28/2014. Publications Peer Reviewed Publications 2015: 1.Jianhua Wang, Jianrong Dai, Yongjie Jing, Yanan Huo, and Tianye Niu, Methodology for registration of shrinkage tumors in head and neck CT studies, Comput Math Method M., 2015 (under review) 2014： 2. Tianye Niu, Xue Dong, Michael Petrongolo and Lei Zhu, Iterative image-domain decomposition for dual-energy CT, Med. Phys., 41(4): 041901, 2014. 3. Tianye Niu, Xiaojing Ye, Quentin Fruhauf, Michael Petrongolo and Lei Zhu, Accelerated barrier optimization compressed sensing (ABOCS) for CT reconstruction with improved convergence. Phys. Med. Bio, 59(7):1801-1814, 2014. 4. Xue Dong, Tianye Niu and Lei Zhu, Combined iterative reconstruction and image-domain decomposition for dual energy CT using total-variation regularization, Med. Phys., 41(5): 051909, 2014. 5. Lei Zhu, Tianye Niu and Michael Petrongolo, Iterative CT reconstruction via minimizing adaptively reweighted total variation. Journal of X-ray science and technology, 22(2): 227-240, 2014. 2013 6. Yifei Lou, Tianye Niu, Xun Jia, Patricio A. Vela, Lei Zhu and Allen R. Tannenbaum, Joint CT/CBCT deformable registration and CBCT enhancement for cancer radiotherapy, Med Image Anal, 17(3):387-400, 2013. 7. X. Dong,M. Petrongolo, T.Y. Niu and L. Zhu, "Low-Dose and Scatter-Free Cone-Beam CT Imaging Using a Stationary Beam Blocker in a Single Scan: Phantom Studies," Comput Math Method M. (2013). 2012： 8. Tianye Niu, and Lei Zhu, Accelerated barrier optimization compressed sensing (ABOCS) reconstruction for cone-beam CT: phantom studies. Med. Phys., 39(7): 4588-4599, 2012. 9. Tianye Niu, Ahmad Al-Basheer and Lei Zhu, Quantitative cone-beam CT imaging in radiation therapy using planning CT as a prior: First patient studies. Med. Phys., 39(4): 1991-2001, 2012. 10. Lei Zhu, Tianye Niu, Kihwan Choi and Lei Xing, Total-Variation Regularization Based Inverse Planning for Intensity Modulated Arc Therapy. Technol Cancer Res Treat. 11(2): 149-162, 2012. 11. Xue Dong, Tianye Niu, Xun Jia, and Lei Zhu, Relationship between x-ray illumination field size and flat field intensity and its impacts on x-ray imaging. Med. Phys., 39(10): 5901-5909, 2012. 2011： 12. Tianye Niu, and Lei Zhu, Scatter correction for full-fan volumetric CT using a stationary beam blocker in a single full scan. Med. Phys., 38(11): 5395-5407, 2011. 2010： 13. Tianye Niu, Mingshan Sun, Josh Star-Lack, Hewei Gao, Qiyong Fan and Lei Zhu, Shading correction for on-board cone-beam CT in radiation therapy using planning MDCT images. Med. Phys., 37(10): 5395-5407, 2010. 14. Tianye Niu and Lei Zhu. Overview of x-ray scatter in cone beam computed tomography and its correction methods. Curr Med Imaging Rev, 6(2):82-89, 2010. 2009 and before (as a Ph.D. student): 15. Lei Liu, Jinxiang Cao, Tianye Niu, et al. Experimental studies of low-pressure plasma jet by means of langmuir probes and emission spectra. Plasma Sci. Tech., 11(3): 307-313, 2009. 16. Chijin. Xiao, Tianye Niu, Jordan Morelli, et al., Design and initial operation of multichord soft x-ray detection arrays on the STOR-M Tokamak, Rev. Sci. Instru., 79(10): 10E926-1-10E926-3, 2008. 17. Mykola Dreval, Chijin Xiao, Dallas Trembach, Akira Hirose, Sayf Elgriw, Andrew Pant, Damian Rohraff and Tianye Niu, Simultaneous evolution of plasma rotation, radial electric field, MHD activity and plasma confinement in STOR-M tokamak, Plasma Phys. Control. Fusion, 50(9): 095014-1 - 095014-13, 2008. 18. Tianye Niu, Jinxiang Cao, Ge Jin, Hao Liang, Ying Zhu, Development of Portable Langmuir Probe DAQ System, Nuclear Electronics & Detection Technology, 28(3), 2008. (In Chinese) 19. Tianye Niu, Jinxiang Cao, Lei Liu, et al, A comparison among optical emission spectroscopic methods of determining electron temperature in low pressure argon plasmas, Chinese Phys, 16(9): 2757-2763, 2007. 20. Tianye Niu, Jinxiang Cao, Lei Liu, et al, The techniques of single probe and emission spectroscopy diagnostics in low temperature argon plasmas, Acta Physica Sinica, 56(4): 2330-2336, 2007. (In Chinese) 21. Zhu Ying，Cao Jin-Xiang，Tianye Niu，Wang Liang，Wang Yan，Wang Ge，Optimization of Langmuir probe system parameters in a stationary laboratory plasma，Plasma Sci. Tech., 8(6):639-643, 2006. 22. Yan Wang，Jinxiang Cao，Ge Wang，Liang Wang，Tianye Niu，Ying Zhu，Total absorption of electromagnetic radiation in overdense plasma，Physics of Plasmas, 13(7): 073301-1 - 073301-9, 2006. 23. Tianye Niu, Weisong Yang, Ge Jin, Hao Liang, Qingqi Wang, The development of a portable multi-channel analyzer, Nuclear Electronics & Detection Technology, 26(4), 2006. (In Chinese) 24. Ge Jin, Tianye Niu, Yangmei Fan, A measurement system for the half life of radionuclide, Nuclear Electronics & Detection Technology, 24(2), 2004. (In Chinese) Guest Editor： Tianye Niu, Mathematical Methods and Applications in Medical Imaging, Computational and Mathematical Methods in Medicine, 2013-2014 Conference proceedings: 1. Xiaoyuan Suo and Tianye Niu, Incorporating entrepreneurship topic into a mobile computing course, IEEE Frontiers in Education Conference, 2014 2. Tianye Niu, and Lei Zhu, Accelerated barrier optimization compressed sensing (ABOCS) reconstruction: performance evaluation for cone-beam CT. IEEE Nuclear Science Symposium Conference (IEEE NSS/MIC), 2012 3. Tianye Niu and Lei Zhu, Low-dose quantitative cone-beam CT imaging in radiation therapy. IEEE NSS/MIC, 2012 4. Xue Dong, Xun Jia, Tianye Niu, and Lei Zhu, Low-dose and scatter-free cone-beam CT imaging: a preliminary study. Proc. SPIE, 8313, 19(1) – 19(11), 2012 5. Tianye Niu, and Lei Zhu, Single-scan scatter correction for cone-beam CT using a stationary beam blocker: a preliminary study. Proc. SPIE, 7961, 261 - 269, 2011. 6. Hewei Gao, Tianye Niu, Lei Zhu and Rebecca Fahrig, Evaluation of an erbium modulator in x-ray scatter correction using primary modulation. Proc. SPIE, 7961, 221 - 227, 2011. Conference presentations: Oral presentations: 1. Tianye Niu, Xue Dong, Michael Petrongolo and Lei Zhu, Iterative Image-Domain Decomposition for Dual-Energy CT, AAPM 56th annual meeting, Aug/2014. 2. Lei Zhu and Tianye Niu. Iterative CT reconstruction via minimizing adaptively reweighted total variation. AAPM 55th annual meeting, Aug/2013. 3. Hongyan Zhang, Lei Liu, Hao Wu, Haizhen Yue, Tianye Niu and Lei Zhu. Quantitative cone-beam CT imaging in radiation therapy using planning CT as a prior: clinical assessments. AAPM 55th annual meeting, Aug/2013. 4. Tianye Niu and Lei Zhu. Accelerated barrier optimization compressed sensing (ABOCS) for CT reconstruction with improved convergence. AAPM 55th annual meeting, Aug/2013. 5. Tianye Niu. Medical Physics: An emerging multidiscipline. Department of Modern Physics, University of Science and Technology of China. Apr/2013. (Invited talk) 6. Tianye Niu and Lei Zhu. The next-generation quantitative and safe cone-beam CT imaging and its applications in radiation therapy. Department of Engineering Physics, Tsinghua University. Mar/2013 (Invited talk) 7. Tianye Niu and Lei Zhu. Accelerated barrier optimization compressed sensing (ABOCS) reconstruction for cone-beam CT. AAPM 54th annual meeting, Aug/2012. 8. Tianye Niu, Ahmad Al-Basheer, and Lei Zhu. Quantitative cone-beam CT imaging in radiation therapy using planning CT as a prior: first patient studies. AAPM 54th annual meeting, Aug/2012. 9. Tianye Niu. Quantitative cone-beam CT imaging in radiation therapy using planning CT as a prior: framework design and first patient studies. Woodruff School of Mechanical Engineering Seminar, Georgia Institute of Technology, Feb/2012. (Invited talk) 10. Tianye Niu and Lei Zhu. Single-scan scatter correction for volumetric CT using a stationary beam blocker: phantom studies. AAPM 53rd annual meeting, Aug/2011. 11. Tianye Niu, Lei Zhu. X-ray Compton scatter imaging on volumetric CT systems. AAPM 53rd annual meeting, Aug/2011 12. Tianye Niu and Lei Zhu. Single-scan scatter correction for cone-beam CT using a stationary beam blocker: theory and preliminary study. SPIE Medical Imaging, Feb/2011. 13. Tianye Niu, Mingshan Sun, Josh Star-Lack, Hewei Gao, Qiyong Fan and Lei Zhu. Shading correction for on-board cone-beam CT in radiation therapy using planning MDCT images. AAPM 52nd annual meeting, July/2010.Poster or second-author conference presentations: 1. Xiaoyuan Suo and Tianye Niu, Incorporating entrepreneurship topic into a mobile computing course, IEEE Frontiers in Education Conference, 2014 2. Michael Petrongolo, Tianye Niu and Lei Zhu, Noise suppression for dual-energy CT through entropy minimization, AAPM 56th annual meeting, Aug/2013. 3. Tianye Niu and Lei Zhu. Fast treatment planning for arc therapy using maximum intensity regularized quadratic optimization (MIRQO). AAPM 55th annual meeting, Aug/2013 4. Tianye Niu and Lei Zhu, Accelerated barrier optimization compressed sensing (ABOCS) reconstruction: performance evaluation for cone-beam CT. IEEE Nuclear Science Symposium Conference (IEEE NSS/MIC), Oct/2012 (Trainee grant). 5. Tianye Niu and Lei Zhu, Low-dose quantitative cone-beam CT imaging in radiation therapy. IEEE NSS/MIC, Oct/2012 (Trainee grant). 6. Qiyong Fan, Tianye Niu and Lei Zhu. Shading correction in image domain for cone-beam CT without prior information. AAPM 54th annual meeting, Aug/2012. 7. Xun Dong, Xun Jia, Tianye Niu, and Lei Zhu, Low-dose and scatter-free cone-beam CT imaging: a preliminary study. SPIE Medical Imaging, Feb/2012. 8. Xue Dong, Tianye Niu, Lei Zhu. Relationship between x-ray illumination volume size and flat field intensity and its impacts on x-ray imaging. AAPM 53rd annual meeting, Aug/2011. 9. Lei Zhu and Tianye Niu. Improving cone-beam CT for radiation therapy. International workshop on Mathematical Problems, Models and Methods in Biomedical Imaging, Feb/2010. (Invited talk) 10. Alice A. Cheung, Tianye Niu, Ji Chen, and Lei Zhu. Noise reduction for multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging. IEEE NSS/MIC Oct/2010. 11. Alice A. Cheung, Tianye Niu, Tracy L. Faber, W. Paul Segars, Lei Zhu, and Ji Chen. Simulation of left ventricular dyssynchrony using the XCAT phantom. IEEE NSS/MIC Oct/2010. Professional Service Journal Reviewer  Medical Physics  Physics of Medicine and Biology  Journal of X-ray Science and Technology  International Journal of Biomedical Imaging  IEEE Signal Processing Letters  British Journal of Radiology  Journal of Radiological Protection  PLOS ONE Member of Faculty Search Committee Professional Memberships 2011- Pres. Junior Member, American Association of Physicists in Medicine 2010- 2012. Member, Society of Photographic Instrumentation Engineers (SPIE)