Profile

Education and professional record:09/1997-07/2001, Bachelor，Nankai University，Biochemistry and molecular biology09/2001-07/2008, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science12/2008-02/2014, Postdoctor，Georgia Regents University , USA02/2014-06/2015, Assistant Research Scientist, Georgia Regents University, USA06/2015-Present, Professor,The Institute of Translational Medicine,The First Affiliated Hospital,Zhejiang University  Research interests:Synapse is a communicating contact between two neurons or a neuron and its target cell. It’s a fundamental unit of neural circuitry and enables complex behaviors.Neuromuscular junction is the synapse between motoneuron and skeleton muscle, controlling our movement. My researches try to better understand 1.The mechanisms of synapse formation and synaptic plasticity;2. The pathogenesis of neurological disorder such as Myasthenia gravis (MG), Amyotrophic lateral sclerosis (ALS),Alzheimer's disease(AD);3. Translational medicine research for neurological disorders  Selective publication:1. Shen C, Xiong WC, Mei L. LRP4 in neuromuscular junction and bone development and diseases. Bone. June 10, 20152. Tao Y*, Shen C*,# Luo S*, Traoré W*, Marchetto S, Santoni MJ, Xu L, Wu B, Shi C, Mei J, Bates R, Liu X, Zhao K, Xiong WC, Borg JP#, Mei L#. Role of Erbin in ErbB2-dependent breast tumor growth.Proc Natl Acad Sci U S A. 111(42):4429-38, 2014 (*,co-first author; #, co-corresponding author).3. Shen C, Xiong WC, Mei L. Caspase-3, Shears for Synapse Pruning. Developmental Cell. 28:604-606, 2014.4. Zhang B*, Shen C*, Bealmear B, Ragheb S, Xiong WC, Lewis R, Mei L. Autoantibodies to agrin in myasthenia gravis patients. PLOS.One. 9(3), 2014 (*, co-first author).5. Shen C*, Lu Y*, Zhang B*, Figueiredo D, Bean J, Jung J, Wu H, Barik A, Yin DM, Xiong WC, Mei L. Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis. Journal of Clinical Investigation 123:5190-202, 2013.6. Tao Y*, Chen YJ*, Shen C*, Luo Z, Bates C, Lee D, Marchetto S, Gao TM, Borg JP, Xiong WC, Mei L. Erbin interacts with TARP gamma-2 for surface expression of AMPA receptors in cortical interneurons.Nature Neuroscience.16:290-299, 2013 (*,co-first author).7. Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase.J Biol Chem. 283:17721-30, 2008.