Profile

1982 B. Med
1998 PhD, The University of Hong Kong
1998-2005 Postdoctoral fellow, The University of Cincinnati, USA, The University of Calgary, Canada
2005-2008 Assistant Professor, The University of Calgary, Canada
2009-Present Professor， Zhejiang University
More than forty papers were published in FASEB J，JBC，Am J Physiol，JPET，Biophysical J, Br J Pharmacol，Biol Reprod，Human Reproduction.
Main research interest: FSHR and dysfunction of blood vessels; Mechanisms of embryo implantation; Differentiation of embryo stem cells.
Grants:
1. National Basic Research Program of China (2012CB944903) 2013-2017, RMB1,200,000
2. National Basic Research Program of China (2011CB944502) 2011-2015, RMB2,500,000
3. National Natural Science Foundation of China （81270708）2013-2016 RMB700,000
4. National Natural Science Foundation of China （81070268）2011-2013 RMB320,000
5. Natural Science Foundation of Zhejiang Province 2010-2013 RMB100.000

Publications (sellected):
1. Liu XM, Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ*, Huang HF*. Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure. J Clin Endocrinol Metab. 2012 2012 Oct;97(10):3672-83. （IF=5.967）
2. Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PCK, Sheng JZ*, Huang HF*: Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia, Diabetes. 2012 May;61(5):1133-42. （IF=8.286）
3. Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Mol Aspects Med. 2012 Oct;33(5-6):676-90. （IF=9.970）
4. Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ*, Huang HF*. Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53. （IF=5.967）
5. Zhou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, Liu AX, Wang TT, Leung PCK, Sheng JZ*, Huang HF*. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab.2011 Sep;96(9):E1399-408.（IF=5.967）
6. Raqeeb A， Sheng JZ，Ao N, Braun A. Purinergic P2Y2 Receptors Mediate Rapid Ca2+ Mobilization, Membrane Hyperpolarization and Nitric Oxide Production in Human Vascular Endothelial Cells. Cell Calcium 2011 Apr;49(4):240-8. (SCI收录，IF：4.288).
7. Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PCK, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab.2011 Mar;96(3):E493-7. （IF=5.967）
8. Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PCK, Huang HF. G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve. Fertil Steril. 2010 Nov;94(6):2490-2.（IF=3.970）
9. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod. 2010, 25(6):1441-450.（IF=3.859）
10. Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.（IF=5.520）
11. Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PC, Sheng JZ, Huang HF. Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol. 2009 Dec 7;7:144（IF=2.634）
12. Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of SKCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45 （IF=7.049）