Profile

Xiuwen Tang, Ph.D., Professor of Biochemistry, Zhejiang University School of Medicine, Hangzhou, China.

He received his BS and Msc from Lanzhou University, China, and his Ph.D. degree from Sheffield University, UK. His main research interests include the molecular mechanism of the dysregulation of the KEAP1/NRF2 pathway and exploring the therapeutic potential of NRF2 inhibitors in NSCLC. Xiuwen Tang has a total of more than 40 publications in peer reviewed journals.  He is currently a reviewer of 5 biomedical journals and His recent work on the role of NRF2 pathway in drug resistance has won the award for progress in science and technology of Zhejiang Province.

Selected publications:
Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ*, Tang X*.2013 RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2. Cancer Res. 73(10)，2013， 3097-108. （IF：9.2）

Tang X*et al Modulation of Nrf2 signaling pathway by nuclear receptors: Implications in Cancers. Biochimica et Biophysica Acta – Molecular Cell Research 2013（Invited Review）（IF：5.5）

Xiuwen Tang*, Hongyan Wang, Longfang Fan, Xiaoyuan Wu, Ai Xin, Huanyu Ren and Xiu Jun Wang* Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs Free Radical Biology and Medicine 50(11), 2011, 1599-1609 （IF：6.1）