Profile

Education

09/2006-06/2011 Ph.D. in Chemistry & Biomedical Engineering, Zhejiang University & Harvard University (Joint PhD Program)

09/2004-06/2006 M.S. in Biology, Zhejiang University, China (Graduated with Honor)

09/2000-06/2004 B.S. in Chemical Engineering, Qufu Normal University, China (Graduated with Honor)

Professional Appointments

07/2013-          Associate Professor & Qiushi Young Scholar, Institute of Translational Medicine, School of Medicine, Zhejiang University

07/2011-07/2013   Post-doctoral Research Fellow, Zhejiang University

01/2010-01/2011   Research Scholar in Wyss Institute for Biologically Inspired Engineering, Harvard University

01/2009-01/2010   Research Scholar in Division of Health Sciences and Technology (HST), Harvard-MIT

12/2006-12/2008   Research Assistant in Center for Biomaterials and Biopathways, Zhejiang University

09/2006-07/2007   Teaching Assistant in Department of Chemistry, Zhejiang University

Area of Research

The Wang laboratory uses an interdisciplinary approach that integrates material science, biology, chemistry and engineering to solve problems in human health. It is emphasized that using Nature's design principles to develop bio-inspired materials and devices, and ultimately, transform medicine. From the physicochemical perspective, they are focused on understanding the molecular mechanisms involved in the interfaces of cell-cell, cell-materials, and develop the tools for cancer diagnosis and personalized medicine.

1. Cellular interfacial engineering

Cellular interfacial engineering here as a avenue of research covers two points, Firstly, it is with the purpose of exploring the molecular structure of cells from a biological perspective and secondly it aims at discovering the properties of materials from the scope of material science, such as surface topography and structure of extracellular matrix (ECM), cell size and shape, and so on.

2. Diagnostic macro/micro-devices based on cellular interface

Cell rolling and migration is an important physiological (such as tissue repair) and pathological process (such as cancer metastasis) that is used to recruit specific cells in the bloodstream to a target tissue. Learn from the similar process, we aim to develop microfluidics/paper-based technologies to sort cells (for more broad vision, exosome or bio-macromolecules such as DNA/RNA/proteins included) for cancer diagnostic and therapeutic applications.

3. Therapeutic micro/nano-tools based on cellular interface

Long systemic circulation lifetime is vital for drug delivery because long-circulating vehicles can more effectively localize in the disease sites, such as tumors and cardiovascular lesions. Erythrocytes, or red blood cells, are Nature's long-circulating delivery vehicles. We are interested in exploring and demonstrating the mechanism responsible for its roles. It will inspire the design and engineering of man-made delivery systems for cancer treatment in the future.

Focus

We focus on the biologically interficial engineering for translationla medicine, especially to study the interfaces of cell-cell, cell-materials, and develop the tools for cancer diagnostics and personalized therapeutics.

Funding Information

2015-2017 NSFC Young Investigator Grant 81401541 (Principal Investigator)

            The cell sorting system based on cell-materials interfacial engineering

2015-2017 Major Project of Science and Technology Department of Zhejiang Province 2014C03048-2 (Co-PI)

           CTC chip: The integrated system for cancer diagnostics, intervention and prognostics

2013-2014 The Special Support from China Postdoctoral Science Foundation (6^th)

            2013T60600 (Principal Investigator)

            Universal red cells by a simple cell-superficial-engineering for blood transfusion

2011-2013 The First Class General Financial Grant from the Chinese Postdoctoral Science Foundation (50^th) 2011M500136 (Principal Investigator)

            Preserving cell viability at positive temperatures

2008-2010 The Chinese Universities Scientific Fund awarded by the China Scholarship Council (CSC) 2008632016 (Awardee)

Patents

1. Ben Wang, Yun Xiao, Ruikang Tang. One kind of Microfluidics chip for cell sorting and harvest & its applications. Zhejiang University. Patent Number 201410467913.4.

Publications (Citations: > 700, h-index: 10)

A) Book Chapter

1.      Wang B, Cell Surface Engineering: Fabrication of Nanocarrier Cells (Functional multilayered polyelectrolyte assemblies on biological cells). Fakhrullin R, Choi I and Lvov Y (Ed.). Royal Society of Chemistry (UK), 2014

B) Journal Articles

2014

1.      Xiao Y, Zhou H, Xuan N, Cheng M, Luo Y, Wang B*, Tang R. Effective and selective cell retention and recovery from whole blood by electroactive thin films. ACS Appl. Mater. Interfaces2014, 6 (23), 20804–20811. (* Corresponding author, IF=5.900)

2.      Rao Y, Chen W, Liang X, Huang Y, Miao J, Liu L, Lou Y, Zhang X, Wang B, Tang R, Chen Z, Lu X. Epirubicin‐Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier. Small ASAP(IF=7.514)

3.      Wang B*, Zhou H, Luo Y, Tang R, Zheng S. Biological interfacial engineering for metastatic cancer diagostic and Intervention. Curr. Med. Chem. 2014, 21 (22), 2510-2521. (* Corresponding author, IF=3.715)

4.      Wang B, Wang G, Zhao B, Chen J, Zhang X, Tang R. Antigenically sheltered universal red blood cells by polydopamine-based cell surface engineering. Chem. Sci. 2014, 5 (9), 3463-3468. (IF=8.601)

·           Highlighted by Chemistry World (RSC).

5.      Wang B, Liu P, Liu Z, Pan H, Xu X, Tang R. Biomimetic construction of cellular shell by adjusting the interfacial energy. Biotechnol. Bioeng. 2014, 111 (2), 386-395. (IF=4.164)

2013

6.      Wang B, Tang R. Biomineralization: One promising bridge between inorganic chemistry and biomedicine. Prog. Chem. 2013, 25 (4), 633-641.(IF=0.714)

7.       Liu P, Chen Y, Wang G, Wang B, Xu X and Tang R.Cell death induced by in situ mineralized calcium phosphate in growth microenvironment. Chinese J. Inorg. Chem. 2013, 29 (1), 89-94. (IF=0.628)

2012

8.      Coutinho D, Sant S, Shakiba M, Wang B, Gomes M, Neves N, Reis R, Khademhosseini A. Microfabricated photocrosslinkable polyelectrolyte-complex of chitosan and methacrylated gellan gum. J. Mater. Chem. 2012, 22 (33), 17262-17271. (IF=5.968)

2011

9.      Xu X*, Wang B, Tang R. Hybrid materials that integrate living cells: Improved eco-adaptation and environmental applications. ChemSusChem 2011, 4 (10), 1439-1446.(* Corresponding author, IF=6.827)

10. Mahmoudi M*, Sant S, Wang B, Laurent S and Sen T. Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy. Adv. Drug Deliver. Rev. 2011, 63 (1-2), 24-46. (* Corresponding author, IF=11.502)

11. He J, Du Y, Guo Y, Hancock MJ, Wang B, Shin H, Wu J, Li D, Khademhosseini A. Microfluidic-based synthesis of composite materials with cross-gradient for screening cell-biomaterial interactions. Biotechnol. Bioeng. 2011, 108 (1), 175-185. (IF=3.946)

12. Wu J, Wheeldon I, Guo Y, Lu T, Du Y, Wang B, He J, Hu Y, Khademhosseini A. A sandwiched microarray platform for benchtop cell-based high throughput screening. Biomaterials 2011, 32 (3), 841-848. (IF=7.404)

13. Xiao W, He J, Nichol JW, Wang L, Huston CB, Wang B, Du Y, Fan H, Khademhosseini A. Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating network hydrogel. Acta Biomater. 2011, 7 (6), 2384-2393.(IF=4.865)

2010

14. Wang B, Liu P and Tang R. Cellular shellization: Surface engineering gives cells an exterior. BioEssays 2010, 32 (8), 698-708. (IF=4.479)

15. Wang B, Liu P, Tang Y, Pan H, Xu X and Tang R. Guarding embryo development of zebrafish by shell engineering: A strategy to shield life from ozone depletion. PLoS ONE 2010, 5 (4), e9963. (IF=4.411)

16. Du Y, Hancock MJ, He J, Villa-Uribe JL, Wang B, Cropek DM, Khademhosseini A. Convection-driven generation of long-range material gradients. Biomaterials 2010, 31 (9), 2686-2694. (IF=7.883)

17. Hancock M, Du Y, He J, Villa-Uribe J, Wang B, Cropek D, Khademhosseini A. Generating long material gradients by convection and alternating flow in a microchannel. Bioengineering Conference, Proceedings of the 2010 IEEE 36^th Annual Northeast. 2010, 1-2.

2009

18. Jiang W, Chu X, Wang B, Pan H, Xu X and Tang R. Biomimetically triggered inorganic crystal transformation by biomolecules: A new understanding of biomineralization. J. Phys. Chem. B 2009, 113 (31), 10838-10844. (IF=3.471)

2008

19. Wang B, Liu P, Jiang W, Pan H, Xu X and Tang R. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralization. Angew. Chem. Int. Ed. 2008, 47 (19), 3560-3564. (IF=10.232)

·           Selected by Faculty of 1000 Biology (F1000 Factor 9.0)

·           Highlighted by Nature China, Reuters, Chemical & Engineering News (ACS), Chemical Science (RSC), Physorg and New Scientist, etc.

20. Tao J, Pan H, Wang J, Wu J, Wang B, Xu X and Tang R. Evolution of amorphous calcium phosphate to hydroxyapatite probed by gold nanoparticles. J. Phys. Chem. C2008, 112 (38), 14929-14933. (IF=3.396)

Lecture Presentations

1.      Cellular Interfacial Engineering for Single Cell Modification and Manipulation. Speaker in 121th Xi-Hu Forum of Translational medicine in Oncology, Nov 5^th, 2014 Hangzhou, China.

2.      Cellular Interfacial Engineering for Single Cell Modification and Manipulation. Invited speaker in Basic-Clinical Joint Forum, Oct 31th, 2014 Hangzhou, China.

3.      Cellular Interfacial Engineering for Single Cell Modification and Manipulation. Invited speaker in the 1^st East Asian Forum on Biofunctional Materials and Regenerative Medicine, April 18-22, 2014 Hangzhou, China.

4.      Cellular interfacial engineering for translational medicine. Invited speaker in The Second Affiliated Hospital School of Medicine, Zhejiang University, May 7, 2014 Hangzhou, China.

5.      Biological interfacial engineering for translational medicine research. Faculty position searching seminar in School of Medicine, Zhejiang University, March 28, 2013 Hangzhou, China.

6.      Cell microenvironment-based tumor targeting strategy. The 11^th National Conference on Biological Inorganic Chemistry, September 16-19, 2011 Baoding, China.

7.      Nanobiology: Vital problems of single-cell biomineralization. The 6^th Zhejiang University doctoral Innovation Forum, November 26, 2008 Hangzhou, China.

Poster Presentations

1.      Wang B, Tang R. Cellular Interfacial Engineering for Single Cell Modification and Manipulation. AACR New Horizons in Cancer Research Conference 2014, Oct 9-12, 2014 Shanghai, China.

2.      Wang B, Sant S, and Khademhosseini A. Cell-responsive programmable hydrogels for targeting tumor microenvironment. The 2^nd Wyss Retreat, Nov. 22, 2010 Boston, USA.

3.      Wang B, Sant S, Tang R and Khademhosseini A. Injectable MMPs-sensitive hydrogel system for local delivery and intracellular cancer targeting. The 1^st Wyss Retreat, Nov. 23, 2009 Boston, USA.

Professional Societies

Member of the American Chemical Society (ACS),

The American Association for Cancer Research (AACR),

Chinese Society of Biomedical Engineering, and

Zhejiang Biomedical Society.

Professional Services

Journal Reviewing: ACS Applied Materails & Interfaces,

ACS Nano,

Angewandte Chemie International Edition,

Biochemical Sciences

Cancer Letters

Colloids and Surfaces B

Current Pharmaceutical Design,

Journal of Controlled Release,

Journal of Crystal Growth

Journal of Physical Chemistry C,

Journal of the American Chemical Society,

Microfluidics and Nanofluidics

                  Mini-reviews in Medicinal Chemistry

Honors and Awards

2014   Outstanding Faculty Member (Institute of Translational Medicine)

2008   Haizheng Scholarship (Hisun Chemical Co., Ltd., 1^st in College)

2006   Excellent Graduate (Zhejiang University, 2 years in a row)

2005   Excellent Student Leader (Zhejiang University)

2004   Excellent Graduate (Qufu Normal University,4 years in a row)

2003   Excellent Student Leader (Qufu Normal University)

2002   Excellent Student (Qufu Normal University)

2001   Outstanding Community Volunteer (Qufu Normal University)

2000   Outstanding Individual (Qufu Normal University, 2 in college)