Profile

Dr. Jian-an Wang is a interventional cardiologist, graduated from Hunan Medical College in 1978. Because of his great achievement，he is a full professor and doctor supervisor of cardiology of Zhejiang University now. As a cardiologist, he does cardiac procedures over 1000 cases per year，such as percutaneous coronary angiogr1aphy (PTCA), radiofrequency catheterization ablation (RFCA), pacemaker implantation, percutaneous closure of a residual ventricular septal defect (VSD), atrial septal defect (ASD) and patent ductus arteriosus (PDA) with the Amplatzer occluder etc. He has great experiences in the treatment of common cardiovascular diseases and emergencies and saved a lot of patients. Dr. Wang is also interested in the scientific research which is focused on the coronary heart diseases and mesenchymal stem cells, characteristics and mechanisms of its effectiveness to the ischemic heart diseases. He acquired more than ten grants, including National Science Foundation of China, Nature Science Foundation of Zhejiang Province, Science and Technology Projects of Zhe jiang Province, has published over 150 papers and gained many national or Zhejiang provincial Science and Technology advancement Awards.
Curriculum Vitae
Jian-an Wang
（Date prepared Feb/12/2012）

Date of Birth: November 12, 1961
Work address: Heart Center
Second Affiliated Hospital of Zhejiang University School of Medicine
88 Jiefang Road
Hangzhou, 310009
P. R. China
Tel: 86-571-87315001
Cell: 86-15990086511
Fax: 86-571-87022776
email: wang_jian_an@tom.com (Business)
wja@zju.edu.cn (Private)
Home address: 111 Jiefang Road,
Jin Qian Building, Room 1301
Hangzhou, 310009
P. R. China

EDUCATION AND TRAINING

1983: Bachelor of Medicine, Clinical Medicine, Hunan Medical University, China
1989: Master of Medicine, Cardiology, Zhejiang Medical University, China
1992: Visiting Scholar, Clinical Cardiology, Queen Mary Hospital, Hongkong, China
1993: Visiting Scholar, Interventional Cardiology, Loma Linda University Medical Center, U.S.A.
2000: Doctor of Philosophy, Cardiology, Zhejiang University School of Medicine, China

HONORS AND AWARDS

2000: Excellent Doctor Thesis Award, Zhejiang University
2000: Excellent Natural Science Article Award of Zhejiang Province
2001: Science and Technology Advancement Award, Zhejiang Province
2001: Science and Technology Advancement Award, Zhejiang Province Education Office
2002: Science and Technology Advancement Award, Zhejiang Province
2004: Chinese Medical Science and Technology Award, Chinese Medical Association
2005: Science and Technology Advancement Award, Zhejiang Province
2006: Excellent Natural Science Article Award, Zhejiang Province
2008: Science and Technology Advancement Award of Zhejiang Province
2010: "Young and Middle-aged Expert with Outstanding Contribution", Chinese Ministry of Health
2011: "Young and Middle-aged Expert with Outstanding Contribution", Zhejiang Province
2011: Hospital President with the Most Leadership in China, China Hospital CEO Journal
2011: Premium Specialist of Zhejiang Province, Zhejiang Province
2011: Excellent Teaching Award, Zhejiang University
2011: Excellent Teaching Award, Zhejiang Educational Committee
PROFESSIONAL EXPERIENCE

Academic Appointment and Administrative Responsibility
1983-1990 Resident, Cardiology, Second Affiliated Hospital of Zhejiang Medical University
1988-1990 Chief Resident, Cardiology, Second Affiliated Hospital of Zhejiang Medical University
1990-1995 Fellow, Cardiology, Second Affiliated Hospital of Zhejiang Medical University
1995- Attending, Cardiology, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
1999- 2005 Chief, Cardiology, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
1999-2005 Chief, Cardiology, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
1998-2000 Associate Professor, Cardiology, Zhejiang University
2000- Professor, Cardiology, Zhejiang University
2001- Professor, Emergency Medicine, Zhejiang University
2002-2005 Vice President, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
2003- Vice President, Institute of Cardiology, Zhejiang University
2005- 2009 Vice President, Second Affiliated Hospital of Zhejiang University School of Medicine
2008- Fellow of American College of Cardiology
2009- President, Second Affiliated Hospital of Zhejiang University School of Medicine
2009- Associate Dean, Zhejiang University School of Medicine
2009- Director, Zhejiang Provincial Key Laboratory of Cardiovascular Disease

Memberships of Medical Societies and Scientific Journals
-- Chinese Society of Cardiology
-- Chinese Electrocardiophysiology and Pacing Association
-- Chinese Association of Cardiologist
-- Chairman of Zhejiang Cardiology Association
-- Predecessor Chairman of Zhejiang Electrocardiophysiology and Pacing Association
-- Chairman of Zhejiang Cardiologist Association
-- Chairman of Zhejiang Cardiology Intervention Quality Control Center
-- Chairman of Zhejiang Cardiology Intervention Specialist Committee
-- Chief Editor of “Journal of Electrocardiology and Circulation”
-- Chief Editor of “World Journal of Emergency Medicine” (English version)
-- President and Associate Editor-in-Chief of “Chinese Journal of Emergency Medicine”
-- Reviewer of “Acta Pharmacologica Sinica”
-- Reviewer of “Journal of Zhejiang University Science”
-- Reviewer of “ Chinese Medical Journal” (English version)
-- Reviewer of “the European Heart Journal Excerpts Chinese edition”
-- Reviewer of “Circulation Chinese Edition”
-- Reviewer of “AHA Journals Best Selection Chinese edition”
-- Reviewer of “ Journal of Clinical Electrocardiology”
-- Reviewer of “ Journal of Cardiac and Cerebral Vessel Disease ”


TEACHING ACTIVITIES

1995-2002 Clinical Skill Training
Residents & Junior Fellows (Sir Run Run Shaw Hospital)
Course Chair

1997- Internal Medicine
Third & Fourth year medical students (Zhejiang University)
Instructor

1997-2006 Cardiology
Seven-year-system medical students (Zhejiang University)
Course Chair

2001- 2011 Special Topics in Cardiology
M.D., Ph.D. candidates (Zhejiang University)
Instructor

2001- Medical Terminology
M.D., Ph.D. candidates (Zhejiang University)
Course Chair

2012- Special Topics in Cardiology
MD, PhD candidates (Zhejiang University)
Course Chair


RESEARCH SUPPORT
Research Supports (Active as P.I.)

-- Chinese National Key Technology R&D Program
2011BA11B00 01/01/2012- 12/31/2015 RMB 6,000,000
“The Research of Key Techonology in Monitoring, Prevention and Therapy of Cardiovascular Disease and Risk Factors”

-- Chinese National Programs for High Technology Research and Development( Also as “863 Program”)
2011AA020102 01/01/2011-12/31/2015
“Translational Research Translational Research of Bone marrow mesenchymal stem cell transplantation on Ischemic Heart Disease”

-- National Science and Technology Major Projects for "Major New Drugs Innovation and Development"
2011ZX09302-002-02 01/01/2011- 12/31/2013
“The Platform Construction for Clinical Evaluation and Research Technology of New Cardiovascular Drugs”

-- The Ministry of Health Industry fund
201002014 01/01/2011- 12/31/2013
“Standardized treatment and Key Technologies of Disaster and Severe Trauma”

-- National Natural Science Foundation of China
81171497 01/01/2011- 12/31/2015
“Effect of CARP on Cardiac Ischemia Injury and the Underlying Mechamism”

-- National Natural Science Foundation of China
31171418 01/01/2011- 12/31/2015
“The Study of Leptin-dependent Bone Marrow-derived Mesenchymal Stem Cell Viability and Migration.”

-- Projects of International Cooperation National Natural Science Foundation of China
81128003/H0203 01/01/2011- 12/31/2015
“Effect of Protein Kinase C epsilon on Bone Marrow-derived Mesenchymal Stem Cell Protecting Cardiomyocytes Apoptosis and the underlying mechanism”

-- Key Medical Subjects Construciton Project of Zhejiang Province
XKQ-008-002 01/07/2008- 03/30/2013
“Construction Project of Metabolism and Cardiovascular Key Subjects Group”

-- CMB “National Residency Training Program”
08-930 01/07/2009- 06/30/2013

-- The Ministry of Health Industry Fund
N20100503 07/12/2009- 12/31/2012
“Study of Key Techonology in Monitoring, Prevention and Therapy of Cardiovascular Disease Treatment Program of Atrial Fibrillation and Sudden Cardiac Death Based on Community”

--Key Innovation Team Program of Zhejiang Province
2010R50047 01/01/2011- 12/31/2013
“Innovation Team of Technical Research and Development for Stem Cell Clinical Application”

Research Supports (Completed in the last 3 years as P.I.)

-- Zhejiang Administrative Bureau of Chinese Medicine
ZK23812 01/01/2007- 12/31/2009
“Establishment of Cardiovascular and Metabolic Diseases Laboratory Fund”

-- National Natural Science Foundation of China
J20060479 01/01/2007- 12/30/2009
“Tie2/Ang-1 Signaling Enhance Bone Marrow Derived Stem Cell Survival and Paracrine Effect”

-- Zhejiang Natural Science Foundation
J20060699 12/30/2006- 12/31/2009
“Outstanding Researher Training Project”

-- Zhejiang Administrative Bureau of Chinese Medicine
01/01/2007- 12/31/2010
“Zhejiang Provincial Key Project of Combination of Chinese and Western Medicine”

-- National Natural Science Foundation of China
J20070657 08/11/2007- 12/31/2010
“Heparanase Enhance Bone Marrow Derived Mesenchymal Stem Cell Migration and Angiogenesis”

-- National Administrative Bureau of Chinese Medicine
TCM-2009-181 01/12/2009- 12/31/2011
“Establishment of Cardiovascular Pharmacology Laboratory of Chinese Medicine Fund”

-- Zhejiang Administrative Bureau of Science and Technology
N20100503 01/02/2010- 12/31/2011
“Bone Marrow Derived Mesenchymal Stem Cell Transplantation promote Neuro-regeneration and Electrical-remodeling”

-- Zhejiang Provincial Key Laboratory of Cardiovascular Disease Fund
J20100160 04/20/2010- 12/31/2011
“Establishment of Zhejiang Provincial Key Laboratory of Cardiovascular Disease Fund”



LAB MEMBERS

A. CURRENT GRADUATE STUDENTS (Master candidate)

Lihan Wang

Na Zhang

Po Hu

Jiayin Fu

Feimin Ye

Ying Wang

Zhezhe Luo

Huajun Li

Jubo Jiang

B. PAST GRADUATE STUDENTS (Master of medicine)

Yong Sun

Xia Sheng

Youqi Fan

Changling Li

Xinwen Liu

Ze Zhong

Hong Tong

Jiong Zhou

Shuijiang Song

Qian Yang

Jiang Li

Pinfang Ren

Siliang Xia

Xiaoming Bao

Xiaohong Fei

Laijing Du

Keqiang Liao

Yuhong Xu

Xin Yang

Yu Zhang

Wen Hua

Ping Mao

Fangfei Liu

Jianwu Zheng

Honghao Bi

Zhe Gu

Qishan Chen

Jie Chen

Ling Wei

Heng Shi

Yun Jiang

Wei Feng

Yifan Wang

Wenxia Wang



C. CURRENT Ph.D. STUDENTS

Name Year Advanced to Candidacy

Yue Wang 2005

Wen-ai Chen 2007

Han Chen 2008

Minjia Yu 2009

Panpan Chen 2009

Binyin Li 2009

Ying Zhang 2009

Huiqiang Chen 2010

Zhi Jiang 2010

Yinchuan Xu 2011

Yu Zhou 2011



D. PAST M.D. or Ph.D. STUDENTS

Year M.D. or Ph.D. Institutional
Name Granted Affiliation Title

Jun Jiang 2006 Second Affilated Hospital, ZJUSM Associate Professor

Xiaojie Xie 2007 Second Affilated Hospital, ZJUSM Associate Professor

Xinyang Hu 2007 Second Affilated Hospital, ZJUSM Associate Professor

Jiahui Li 2007 China-Japan Friendship Hospital Cardiology Fellow

Nan Zhang 2007 Sir Run Run Shaw Hospital, ZJUSM Associate Professor

Liang Dong 2008 Second Affilated Hospital, ZJUSM Cardiology Fellow

Tielong Chen 2008 Hangzhou Hospital of Chinese Medicine Cardiology Attending

Chun Gui 2008 Guangxi Provincial Hospital Cardiology Fellow

Shaoping Wang 2008 Beijing Anzhen Hospital ER Fellow

Ronghua Luo 2008 Hangzhou Red Cross Hopstial ICU Fellow

Xianbao Liu 2009 Second Affilated Hospital, ZJUSM Resident

Aina He 2009 Six People’s Hospital of Shanghai Resident

Xiaofeng Chen 2009 Kentucky University Postdoctoral Fellow

Qiyuan Xu 2010 Hangzhou Binjiang Hospital Resident

Feng Gao 2010 Zhejiang Provincial Hospital Cardiology Fellow

Zhaoxia Pu 2011 Second Affilated Hospital, ZJUSM Cardiac Imaging Fellow

Weifang Yu 2011 UCSD Research Assistant

Yaping Wang 2011 Second Affilated Hospital, ZJUSM Resident



E. CURRENT POSTDOCTORAL SCHOLARS

Name
Degree Institute Current title Years in lab
Zhaocai Zhang M.D. & Ph.D.
Medicine Fudan University
2007 Postdoctoral Scholar 2009- current

Zhihong Zhu
Ph.D,
Biotechnology
Zhejiang Universtiy
2011
Postdoctoral Scholar
2011- current


BIBLIOGRAPHY

1. Wang JA, Lau CP, Tai YT, Wu BZ. Effects of flecainide on exercise hemodynamics and electrocardiography in patients without structural heart disease. Clin Cardiol. 1995 Mar; 18(3): 140-4.

2. Wang J, Chung Ann Choo D, Zhang X, Yang Q, Xian T, Lu D, Jiang S. The effect of transient balloon occlusion of the mitral valve on left atrial appendage blood flow velocity and spontaneous echo contrast. Clin Cardiol. 2000 Jul;23(7):501-6.

3. Wang J, Zhang X, Yang Q, Xian T, Lu D, Shan J, Choo DC. The effect of transient balloon occlusion of the mitral valve on left atrial appendage blood flow velocity and spontaneous echo contrast: a comparison in sinus rhythm and atrial fibrillation patients. Chin Med J (Engl). 2000 May;113(5):412-7.

4. Guo H, Lu D, Wang J, He H, Zhou B, Jiang C. Study on the relation between hypertensive left ventricular hypertrophy in very old people with neurohormonal factors and ventricular arrhythmias. Zhonghua Nei Ke Za Zhi. 2000 Dec;39(12):825-7.

5. Min JY, Meissner A, Wang J, Morgan JP. Mibefradil improves beta-adrenergic responsiveness and intracellular Ca(2+) handling in hypertrophied rat myocardium. Exp Biol Med (Maywood). 2002 May;227(5):336-44.

6. Jiang J, Wang JA, Chen XY, Lu D. Radiofrequency catheter ablation autonomic nerve injury. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Jun;31(3):195-198.

7. Geng X, Jin GD, Fu GS, Ji MA, Shan J, Wang JA. Polymorphisms in the genes for coagulation factor II, V, VII in patients undergoing coronary angiography. J Zhejiang Univ Sci. 2003 May-Jun;4(3):369-73.

8. Min JY, Meissner A, Feng X, Wang J, Malek S, Wang JF, Simon R, Morgan JP. Dantrolene: effects on abnormal intracellular Ca(2+) handling and inotropy in postinfarcted rat myocardium. Eur J Pharmacol. 2003 Jun 13;471(1):41-7.

9. Wang J, Xie X, He H, Huang J, Lu D, Yang Q. Hypercoagulability existing in the local left atrium of patient with mitral stenosis. Chin Med J (Engl). 2003 Aug;116(8):1198-202.

10. Jiang CY, Zhao LL, Wang JA, Mohammod B. Anticoagulation therapy in intra-aortic balloon counterpulsation: does IABP really need anti-coagulation? J Zhejiang Univ Sci. 2003 Sep-Oct;4(5):607-11.

11. Wang JA, Sun Y, He H. Ultrasound ablation of pulmonary veins for treatment of paroxysmal atrial fibrillation. J Zhejiang Univ Sci. 2003 Nov-Dec;4(6):745-8.

12. Guo H, Lee JD, Ueda T, Shan J, Wang J. Plasma homocysteine levels in patients with early coronary artery stenosis and high risk factors. Jpn Heart J. 2003 Nov;44(6):865-71.

13. Guo H, Lee JD, Ueda T, Cheng J, Shan J, Wang J. Hyperhomocysteinaemia & folic acid supplementation in patients with high risk of coronary artery disease. Indian J Med Res. 2004 Jan;119(1):33-7.

14. Guo H, Cheng J, Lee JD, Ueda T, Shan J, Wang J. Relationship between hypertensive left ventricular hypertrophy, neurohormonal factors and ventricular arrhythmias in very old patients. Acta Cardiol. 2004 Feb;59(1):47-50.

15. Guo H, Cheng J, Lee JD, Ueda T, Shan J, Wang J. Relationship between the degree of intracellular magnesium deficiency and the frequency of chest pain in women with variant angina. Herz. 2004 May;29(3):299-303.

16. Guo H, Wang J, Chen J, Shan J, Lee JD, Ueda T. Percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy: Acute results and three-year noninvasive follow-up in 18 patients. Can J Cardiol. 2004 Jun;20(8):779-82.

17. Jiang CY, Li N, Wang JA. Use of B-type natriuretic peptide in evaluation of early percutaneous coronary intervention in patients with acute coronary syndrome. Chin Med J (Engl). 2004 Aug;117(8):1130-4.

18. Wang JA, Li CL, Fan YQ, He H, Sun Y. Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart. J Zhejiang Univ Sci. 2004 Oct;5(10):1279-85.

19. Guo H, Lee JD, Ueda T, Wang J, Lu D, He H, Shan J. Different clinical features, biochemical profiles, echocardiographic and elctrocardiographic findings in older and younger patients with idiopathic dilated cardiomyopathy. Acta Cardiol. 2005 Feb;60 (1):27-31.

20. Zhu JH, Qiu YG, Chen JZ, Zhang FR, Fu GS, Shen FR, Huang WJ, Wang JA, Zhao LL, Tao QM, Zheng LR. Comparison of the antithrombolic effect and safety between intravenous natroparin and unfractionated heparin in patients undergoing percutaneous coronary intervention. Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Apr;33(4):335-9.

21. Li J, Wang JA. The effects of sotalol on ventricular repolarization during exercise. J Zhejiang Univ Sci B. 2005 Apr;6(4):249-53.

22. Wang JA, Fan YQ, Li CL, He H, Sun Y, Lv BJ. Human bone marrow-derived mesenchymal stem cells transplanted into damaged rabbit heart to improve heart function. J Zhejiang Univ Sci B. 2005 Apr;6(4):242-8.

23. Li N, Wang JA. Brain natriuretic peptide and optimal management of heart failure. J Zhejiang Univ Sci B. 2005 Sep;6(9):877-84.

24. Jiang CY, Wang JA, He H, Sun Y, Zhou BQ. Segmental radiofrequency ablation of pulmonary vein ostia for patients with refractory paroxysmal atrial fibrillation using multi-slice spiral computed tomography guidance. J Zhejiang Univ Sci B. 2005 Dec;6(12):1153-6.

25. Dong L, Wang JA, Jiang CY. Validation of the use of foreign gas rebreathing method for non-invasive determination of cardiac output in heart disease patients. J Zhejiang Univ Sci B. 2005 Dec;6(12):1157-62.

26. Yang Q, Wang JA, Dong L, He H, Sheng X, Sun Y, Jiang CY, Zhou BQ. Tissue Doppler imaging evaluate the effect of optimal biventricular resynchronization for congestive heart disease in left ventricular synchrony and function. Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1109-13.

27. Wang JA, Xie XJ, He H, Sun Y, Jiang J, Luo RH, Fan YQ, Dong L. A prospective, randomized, controlled trial of autologous mesenchymal stem cells transplantation for dilated cardiomyopathy. Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Feb;34(2):107-10.

28. Wang JA, Xie XJ. Stem cells transplantation on dilated cardiomyopathy. Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Mar;34(3):200-1.

29. Wang JA, Luo RH, Zhang X, Xie XJ, Hu XY, He AN, Chen J, Li JH. Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction.J Zhejiang Univ Sci B. 2006 Aug;7(8):641-7.

30. Li N, Wang JA. Brain natriuretic peptide: A potential indicator of cardiomyogenesis after autologous mesenchymal stem cell transplantation? J Zhejiang Univ Sci B. 2006 Sep;7(9):766-8.

31. Xie XJ, Wang JA, Cao J, Zhang X. Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin. 2006 Sep;27(9):1153-8.

32. Xiang M, Wang J, Kaplan E, Oettgen P, Lipsitz L, Morgan JP, Min JY. Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. J Gerontol A Biol Sci Med Sci. 2006;61(12):1219-27.

33. Dong L, Wang J, Yang Q, He H, Sun Y, Chen D, Comparison of the Correlation of Rebreathing Method and Echocardiography in Heart Failure Patients With Moderate to Severe Mitral Regurgitation. International Heart Journal. 2007 Jan;48(1):69-78.

34. Hu X, Wang J, Chen J, Luo R, He A, Xie X, Li J. Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardiothorac Surg. 2007 Mar;31(3):438-43.

35. Gui C, Wang JA, He AN, Chen TL, Luo RH, Jiang J, Hu XY, Xie XJ. Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis. Mol Cell Biochem. 2007 Nov;305(1-2):171-8.

36. Wang S, Wang JA, Li J, Zhou J, Wang H. Voltage-dependent potassium channels are involved in staurosporine-induced apoptosis of rat mesenchymal stem cells. Cell Biol Int. 2007 Nov 5.
37. He A, Wang JA, Gui C, Jiang Y, Sun Y, Chen T. Changes of mitochondrial pathway in hypoxia/reoxygenation induced cardiomyocytes apoptosis. Folia Histochem Cytobiol. 2007;45(4):397-400

38. Gui C, Wang JA, He AN, Chen TL, Liu XB, Luo RH, Jiang J. Expression of heregulin and ErbB receptors in mesenchymal stem cells. Chin Med J (Engl). 2008 Jan 20;121(2):155-60

39. Wang JA, Chen TL, Jiang J, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X. Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin. 2008, 29(1):74-82.

40. Wang JA, He A, Hu X, Jiang Y, Sun Y, Jiang J, Gui C, Wang Y, Chen H. Anoxic preconditioning: A way to enhance the cardioprotection of mesenchymal stem cells. Int J Cardiol. 2008 Jan 28.

41. Li JH, Zhang N, Wang JA. Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy. J Endocrinol Invest. 2008;31(2):103-10.

42. Hu X, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis.J Thorac Cardiovasc Surg. 2008;135(4):799-808.

43. Wang SP, Wang JA, Luo RH, Cui WY, Wang H. POTASSIUM CHANNEL CURRENTS IN RAT MESENCHYMAL STEM CELLS AND THEIR POSSIBLE ROLES IN CELL PROLIFERATION. Clin Exp Pharmacol Physiol. 2008 May 23.

44. Liu XB, Jiang J, Gui C, Hu XY, Xiang MX, Wang JA. Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathway. Acta Pharmacol Sin. 2008;29(7):815-22.

45. Chen XF, Wang JA, Lin XF, Tang LJ, Yu WF, Chen H, Xie XJ, Jiang JJ, Peng XH. Diabetes Mellitus: Is It Protective against Aortic Root Dilatation? Cardiology. 2008;112(2):138-143.

46. Chen TL, Wang JA, Shi H, Gui C, Luo RH, Xie XJ, Xiang MX, Zhang X, Cao J. Cyclosporin A pre-incubation attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Scand J Clin Lab Invest. 2008;15:1-9.

47. Chen XF, Tang LJ, Jiang JJ, Jiang J, Hu XY, Yu WF, Wang JA. Increased levels of lipoprotein(a) in non-smoking aortic dissection patients. Clin Exp Med. 2008;8(2):123-7.

48. Liu XB, Wang JA, Yu SP, Keogh CL, Wei L. Therapeutic strategy of erythropoietin in neurological disorders.CNS Neurol Disord Drug Targets. 2008;7(3):227-34.

49. Gui C, Wang JA, Li N, Wang YY, Chen L. Changes of ErbB receptors mRNA expression in left ventricle of myocardial infarction. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(4):381-5.

50. Jiang CY, Gui C, He AN, Hu XY, Chen J, Jiang Y, Wang JA. Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction. J Zhejiang Univ Sci B. 2008 Aug;9(8):630-7.

51. ZHANG N, LI JH, WANG JA, ZHANG HK. The effect of bone marrow mesenchymal stem cell transplantation on diabetic cardiomyopathy. Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Dec;36(12):1115-9.

52. Chen XF, Wang JA, Hou J, Gui C, Tang LJ, Chen XQ, Xie XJ, Jiang JJ, Cai JF, Chen HS, Lu HS, Chen H. Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by Angiotensin II in vitro. Clin Sci (Lond). 2008 Dec 15.

53. Chen XF, Wang JA, Lin XF, Tang LJ, Yu WF, Chen H, Xie XJ, Jiang JJ, Peng XH. Diabetes Mellitus: Is It Protective against Aortic Root Dilatation? Cardiology. 2009;112(2):138-143.

54. Pan XH, Zhong WZ, Xiang MX, Xu G, Shan J, Wang JA. Clinical outcomes of serolimus-eluting stents versus bare metal stents in ST-segment elevation myocardial infarction patients: a meta-analysis.Chin Med J (Engl). 2009 Jan 5;122(1):88-92.

55. Jiang J, Wang J, Li C, Yu SP, Wei L. Dual roles of tumor necrosis factor-{alpha} receptor-1 in a mouse model of hindlimb ischemia. Vasc Med. 2009 Feb;14(1):37-46.

56. Liu XB, Wang JA, Ogle ME, Wei L. Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival. J Cell Biochem. 2009 Feb 19.

57. Wang JA, He A, Hu X, Jiang Y, Sun Y, Jiang J, Gui C, Wang Y, Chen H. Anoxic preconditioning: A way to enhance the cardioprotection of mesenchymal stem cells. Int J Cardiol. 2009 Apr 17;133(3):410-2.

58. Chen XF, Wang JA, Hou J, Gui C, Tang LJ, Chen XQ, Xie XJ, Jiang JJ, Cai JF, Chen HS, Lu HS, Chen H. Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by Angiotensin II in vitro. Clin Sci (Lond). 2009 May 1;116(11):819-26.

59. Mei-xiang Xiang, Ai-na He, Jian-an Wang,and Chun Gui. Protective paracrine effect of mesenchymal stem cells on cardiomyocytes. Journal of Zhejiang University-Science B. 2009 August; 10(8): 619–624.

60. Wang JA, Chen XF, Yu WF, Chen H, Lin XF, Xiang MJ, Fang CF, Du YX, Wang B. Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter. Vascular Medicine. 2009 Nov;14(4):323-9.

61. He A, Jiang Y, Gui C, Sun Y, Li J, Wang JA.The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning. Canadian Journal of Cardiology. 2009 Jun;25(6):353-8.

62. Li-jiang TANG, Jian-jun JIANG, Xiao-feng CHEN, Jian-an WANG, Xian-fang LIN, Yu-xi DU, Cong-feng FANG,Zhao-xia. Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome. Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):592-598.

63. Chang Bian, Yihua Wu, Yu Shi, Geng Xu, Jianan Wang, Meixiang Xiang, Shaoxiang Weng, Jun Jiang and Ji Ma. Predictive value of the relative lymphocyte count in coronary heart disease. Heart Vessels. 2010 Nov;25(6):469-73.

64. Shu-qin YING, Mei-xiang XIANG, Lu FANG, Jian-an WANG. Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention. Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):575-582.

65. Chang Bian, Geng Xu, JiananWang, JiMa, MeiXiang Xiang, and Peng Chen. Hypercholesterolaemic Serum Increases the Permeability of Endothelial Cells through Zonula Occludens-1 with Phosphatidylinositol 3-Kinase Signaling Pathway. Journal of Biomedicine and Biotechnology. 2010 Jan.

66. Xiao-hong PAN, Ying-xue CHEN, Mei-xiang XIANG, Geng XU, Jian-an WANG. A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients.Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010;11(10):754-761.

67. Feng GAO, Xin-yang HU, Xiao-jie XIE, Qi-yuan XU, Ya-ping WANG, Xian-bao LIU, Mei-xiang XIANG, Yong SUN, Jian-an WANG . Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. Zhejiang Univ-Sci B (Biomed & Biotechnol).2010 11(8):608-617.

68. Wang JA. Advances in cardiovascular disease: how far is the summit? Journal of Zhejiang University Science-B. 2010 11(8):547.

69. Wen-xia WANG, Xin-yang HU, Xiao-jie XIE, Xian-bao LIU, Rong-rong WU, Ya-ping WANG, Feng GAO, Jian-an WANG. Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway. Acta Pharmacologica Sinica .(2011) 32: 1483–1490.

70. Xiaojie Xie, Yifan Wang, Songzhao Zhang, Guidi Zhang, Yinchuan Xu, Honghao Bia,Alan Daughertyc, Jian-an Wang.Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. Journal of Nutritional Biochemistry(2011).

71. Hu X, Wei L, Taylor TM, Wei J, Zhou X, Wang JA, Yu SP. Hypoxic Preconditioning Enhances Bone Marrow Mesenchymal Stem Cell Migration via Kv2.1 Channel and FAK Activation. Am J Physiol Cell Physiol. 2011 May 11.

72. Jian-an Wang, Wen-aiChen, YifanWang, SongzhaoZhang, HonghaoBi, BoHong, Yueqiu Luo, AlanDaugherty, XiaojieXie. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis.

73. Guodong Jin, Beili Feng, Peng Chen, Oushan Tang, Jian Wang, Ji Ma, Yuping Shi, Geng Xu.Coagulation Factor XIII-A Val34Leu Polymorphism and the Risk of Coronary Artery Disease and Myocardial Infarction in a Chinese Han Population. Clin Appl Thromb Hemost. 2011 Apr;17(2):208-13.

74. Chun-na JIN , Hong MA , Yan LIN , Jian-an WANG , Mei-xiang XIANG. Association between SNP rs1800875, Serum Chymase and immunoglobin E levels in patients with coronary heart diseasea. J Zhejiang Univ-Sci B (Biomed & Biotechnol) .2011; 12(8):660-667.
75. Yaping Wang, Xinyang Hu, Xiaojie Xie, Aina He, Xianbao Liu and Jian-an Wang. Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts. Experimental Biology and Medicine. 236(2011):1197-1204.

76. Yaping Wang ,Xinyang Hu,Jian-anWang,Meixiang Xiang,Jiekai Yu ,FangfeiLiu , Yan Feng .Application of serum protein fingerprint in diagnosis of coronary artery disease. Clinical Biochemistry.44 (2011): 185 – 191.

77. Meixiang Xiang, Jiusong Sun, Yan Lin, Jie Zhang, Han Chen, Dan Yang, Jianan Wang, Guo-Ping Shi .Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis.215 (2011) :494–499.

78. Hongwei Shao , Qiyuan Xu , Qiuling Wu, Qi Ma , Luis Salgueiro,Jian’An Wang, Darwin Eton, Keith A. Webster, Hong Yu. Defective CXCR4 expression in aged bone impairs vascular regeneration. J. Cell. Mol. Med. 2011;15(10): 2046-2056.

79. Qiyuan Xu, Jian An Wang, Jinlin He, Mingsheng Zhou, Jennipher Adi, Keith A. Webster,Hong Yu. Impaired CXCR4 expression and cell engraftment of bone marrow-derived cellsfrom aged atherogenic mice. Atherosclerosis. 219 (2011): 92–99.

80. Liu XB, Chen H, Chen HQ, Zhu MF, Hu XY, Wang YP, Jiang Z, Xu YC, Xiang MX, Wang JA. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation.J Zhejiang Univ Sci B. 2012 Aug;13(8):616-23.

81. Jiang J, Sun Y, Xiang MX, Dong L, Liu XB, Hu XY, Feng Y, Wang JA. Complex coronary lesions and rotational atherectomy: one hospital's experience. J Zhejiang Univ Sci B. 2012 Aug;13(8):645-51.

82. Shen L, Song LG, Ma H, Jin CN, Wang JA, Xiang MX. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. J Zhejiang Univ Sci B. 2012 Aug;13(8):652-62.

83. Jiang Z, Chen H, Wang J.Right coronary artery fistula to left ventricle treated by transcatheter coil embolization: a case report and literature review. Intern Med. 2012;51(11):1351-3.


PUBLICATED BOOKS

《Valvular Heart Diseases》 (in Chinese)
《Modern Cardiopulmonocerebral Resuscitation》 (in Chinese)
《Common Health Problems in Community》 (in Chinese)
《European PCI Mannul Compendium of 2005》 (in Chinese)
《Recognition Mannul of Common Diseases》 (in Chinese)
《Round Criterion and Example Analysis from an American Perspective》 (in Chinese and English)
《Physiological Pacing》 (in Chinese)
《Mesenchymal Stem Cells for Heart-From Bench to Bedside》 (in English, Springer publication)
《Guidelines for Device-based Therapy of Cardiac Rhythm Abnormalities》 (in Chinese)

PATENTS

-- 2010 Patent number ZL200810121846.5. Ranking of proprietors: 1/5.
A method to enhance the paracrine activity of human bone marrow-derived mesenchymal stem cells.

-- 2011 Patent number ZL200910097997.6. Ranking of proprietors: 1/3.
A method to enhance the anti-apoptotic activity of bone marrow-derived mesenchymal stem cells.

-- 2011 Patent number ZL200910099469.4. Ranking of proprietors: 1/2.
An innovative in vitro culture medium for bone marrow-derived mesenchymal stem cells and its application.

-- 2011 Patent number ZL201010256948.5 Ranking of proprietors: 2/3.
The application of Red yeast rice in producing drugs for abdominal aortic aneurysms.

PENDING PATENT

-- Application Number: 201010557496.4.
A preconditioning method to enhance the migration ability of mesenchymal stem cells.


Conference organizers:

2007- Zhejiang Society of Pacing and Electrophysiology Annual Scientific Session

2007- Chinese Society of Pacing and Electrophysiology Annual Scientific Session

2008-2011 Interventional Cardiovascular Training Course of the Second Affiliated Hospital Zhejiang
University School of Medicine

2009- China Interventional Therapeutics (Annual Conference)

2009- Great Wall International Cardiovascular Conference (Annual Conference)

2009- Qianjiang International Cardiovascular Conference (Annual Conference)

1.Cardiorhythm 2009，2009.2.20-2.22，香港，讲者：treatment to high DFT of ICD
2. the 4th Interventional Cardiology Fellows Course，2009.10.22-10.25，日本，讲者，Left Main Case by Faculty
3.CCT2010,2010.1.28-1.31，日本，讲者：PCI live case
4.18th Annual Scientific Congress-CAP-CCBC(海峡两岸心脏医学论坛)，2010.5.14-5.15，香港，讲者: the practice of compromise in CTO PCI:a case report
5. 臺北醫學大學五十週年校慶系列活動心血管醫學發展研討會，2010.4.15-4.21,台湾，讲者：骨髓间充质干细胞移植治疗心力衰竭
6. APHRS2010，2010.10.28-10.30，韩国，讲者：how to improve the efficiency of CRT.
7. TCTAP2012 , 2012.4.24-4.25，Korea，Lecturer: Complex Coronary Lesions and Rotational Atherectomy by Transradial Approach