Profile

Jianli Wang is Director of Department of Immunology; Professor and doctoral supervisor of Institute of Immunology; Academic leader of Immunology, Zhejiang University. Her main research fields focus on basic and clinical therapeutic research of tumor by immune and genic method. She is the first domestic one who explored novel tumor vaccine through fusion of dendritic cells and tumor cells. She also carried out the research about utilizing exosomes from tumor and dendritic cells as novel tumor vaccine. She had published more than 60 papers in professional magazine and some of these had reached advanced international standards. As the first proposer, she had applied for 12 items of the national patent of invention and been authorized 10 items. She had presided and carried out research of immunotherapy based on dendritic cells and founded the national technical standard about treatment of malignancy by dendritic cells. This project had been approved by SFDA and completed clinical phase II research. The application of clinical phase III had been submitted to SFDA.

Education and Research experiences:
B.S. in Department of Medical, The Second Military Medical University, 1981.8-1986.8
Master in Physiology Research laboratory, The Second Military Medical University, 1986.9-1989.8
Research assistant in laboratory of Epidemiology, Department of Naval Medicine, 1989.9-1992.8
Ph.D. in laboratory of Immunology, shanghai ChangZheng hospital, The Second Military Medical University, 1992.9-1994.7
Lecturer in Laboratory of Immunology, The Second Military Medical University, 1994.8-1996.10
Postdoctoral Fellow in Cleveland Clinic Medical Center, United states, 1996.10-1998.10
Lecturer in Laboratory of Medicine Genetics, The Second Military Medical University, 1998.11-1999.7
Associate Professor in Laboratory of Medicine Genetics, The Second Military Medical University, 1999.7-1999.9
Research Associate in University of Minnesota Cancer Center 1999.9-2000.10
Professor in Institute of Immunology, Zhejiang University, 2000.10－Present
PhD supervisor in Institute of Immunology, Zhejiang University, 2003.9- Present
Director of Institute of Immunology, Zhejiang University, 2006.9- Present

Representative papers：
1. Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cell Mol Immunol. 2010 Jan;7(1):35-43.
2. Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J. . PECAM-1 Ligation Negatively Regulates TLR4 Signaling in Macrophages.J Immunol. 2007 Dec 1;179(11):7344-51. (corresponding author)
3. Yang Y, Xiu F, Cai Z, Wang J, Wang Q, Fu Y, Cao X. Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells. J Cancer Res Clin Oncol. 2007 Jun;133(6):389-99.
4. Xiu F, Cai Z, Yang Y, Wang X, Wang J, Cao X. Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J Mol Med. 2007 May;85(5):511-21 (co-corresponding author)
5. Yan X, Xiu F, An H, Wang X, Wang J, Cao X. Fever range temperature promotes TLR4 expression and signaling in dendritic cells. Life Sci. 2007 Jan 2;80(4):307-13.
6. Zhang Y, Wang X, Xiang Z, Li H, Qiu J, Sun Q, Wan T, Li N, Cao X, Wang J. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Int J Mol Med.2007;19(1):55-63. (corresponding author)
7. Wang Q, Li N, Wang X, Shen J, Hong X, Yu H, Zhang Y, Wan T, Zhang L, Wang J, Cao X. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Life Sci. 2007 Jan 9;80(5):420-9.
8. Li D, Yu H, Huang H, Shen F, Wu X, Li J, Wang J, Cao X, Wang Q, Tang G. FGF receptor-mediated gene delivery using ligands coupled to polyethylenimine. J Biomater Appl. 2007 Sep;22(2):163-80.
9. Wang J, Cao X, Zhang W, Ye T, Tani K. Treatment of leukemia with fibroblast-mediated interferon-alpha gene therapy alone or in combination with doxorubicin. Leukemia Res, 1996;20(5):379-384
10. Wang J, Saffold S, Cao X, Krauss J, Chen W. Eliciting T cell immunity Against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines. The Journal of Immunology. 1998; 161: 5516-5524
11. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem Biophys Res Commun. 2001;281(4):878-883. (co-first author)
12. He X, Wang J, Guo Z, Liu Q, Chen T, Wang X, Cao X. Requirement for ERK activation in sinomenine-induced apoptosis of macrophages. Immunol Lett. 2005, 98(1): 91-96 (co-first author)
13. Sun W, He X, Guo Z, Wang Q, Li X, Rayner J, Zhang L, Wang J, Cao X. IL-12p40-overexpressing immature dendritic cells induce T cell hyporesponsiveness in vitro but accelerate allograft rejection in vivo: Role of NK cell activation and interferon-gamma production. Immunol Lett. 2004, 94:191-199 （co-corresponding author）.
14. Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, Cao X. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol. 2006 ;36(6):1598-607.
15. Wang Q，Liu Y，Wang J，Ding G，ZhangW，Chen G，Zhang M，Zheng S, Cao X. Induction of Allospecific Tolerance by Immature Dendritic Cells Genetically Modified to Express Soluble TNF Receptor. The Journal of Immunology. 2006;177(4):2175-85. (Q.W and Y.L. contributed equally to this study)
16. Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem Biophys Res Commun. 2006 ; 345(3):1122-30.
17. Tang H, Guo Z, Zhang M, Wang J, Chen G, Cao X. Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL- 10. Blood. 2006;108(4) :1189-97.
18. Chen W, Wang J, An H, Zhou J, Zhang L, Cao X. Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways. Immunol Lett. 2005, 98(1): 153-159.
19. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Cao X. Intratumoral injection of interferon-gamma gene-modified dendritic cells elicits potent antitumor effects: effective induction of tumor-specific CD8(+) CTL response. J Cancer Res Clin Oncol. 2005 ;131(7):468-78.
20. Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan T, Cao X. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. Mol Cell Biochem. 2005; 269(1-2):85-94
21. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Liu Y, Cao X. Interferon-gamma is an autocrine mediator for dendritic cell maturation. Immunol Lett. 2004, 94(1-2): 141-151.
22. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells, Nature Immunology. 2004, 5(11):1124-1133.
23. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X. Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood. 2004; 103(2)： 413-421.