Profile

Dr. Xiu Jun Wang gained her Bsc from Lanzhou University and received her PhD from University of London (St. Bartholomew’s Hospital) in UK in 1996. She worked as a Research Fellow during 2000-2009 for Cancer Research UK, and joined School of Medicine, Zhejiang University in 2009.

Research interests: the aims of our research are to understand the effect of environmental toxic chemicals on tumourgenesis and to uncover novel agents for cancer chemoprevention.

Selected publications:
Wang XJ, Hayes JD, Higgins LD, Wolf CR and Dinkova-Kostova AT (2010) Activation of the nrf2 signalling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones. Chemistry & Biology 17: 75-85

Ahn Y-H, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina T, Cole RN, Dinkova-Kostova AT, Talalay P and Cole PA (2010) Electrophilic tuning of the chemoprotective natural product sulforaphane Proc. Natl. Acad. Sci. USA, 107(21): 9590-5

Wang XJ, Hayes JD, Henderson CJ and Wolf CR (2007) Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc. Natl. Acad. Sci. USA, 104(49): 19589-94

Wang XJ, Chamberlain M, Vassieva O, Henderson CJ and Wolf CR (2005) Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Biochem J, 388: 857-867

Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR (2007) Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane. Cancer Research 67 (19): 9289-57

Wright MC, Wang X-J, Pimenta M, Ribeiro V, Paine AJ and Lechner MC(1996) Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid, Molecular

Xiuwen Tang*, Hongyan Wang, Longfang Fan, Xiaoyuan Wu, Ai Xin, Huanyu Ren and Xiu Jun Wang* Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs Free Radical Biology and Medicine 50(11), 2011, 1599-1609 （IF: 6.08）
王秀君 吴加国 唐修文* Nrf2-ARE通路抑制作用研究展望 浙江大学学报（医学版）2010;39(1):1-5