Profile

1)Name: Ximei Wu

2）Address:
Dept. of Pharmacology, school of medicine, zhejiang university, NO. 388, yuhangtang Rd. Hangzhou, 310058 China.
Tel: (86)-571-8898-1121
Fax: (86)-571-8898-1121
Email: xiwu@zju.edu.cn

3）Research Interest:
1. Bone development
2. Osteoblast and chondrocyte differentiation
3. Wnt,Hedgehog and Notch signaling in stem cell development
4. Rho small GTPase in stem cell development


4）Profile:
Career History:
1989—1994：B.Sc. Zhejiang University, School of Medicine.
1994—1997：M.Sc. Zhejiang University, School of Medicine.
1997—1999：Asistant Professor, Zhejiang University, School of Medicine.
1999—2000：Lecturer, Zhejiang University, School of Medicine.
2000—2001：Research Assistant, Osaka Medical University, Japan.
2001—2004：Ph.D. Osaka University, Japan.
2003—2005：Postdoctoral Fellow, Osaka University, Japan.
2005—2008：Postdoctoral Fellow, Washington University in St.Louis, USA.
2008—current：Professor, Zhejiang University, School of Medicine.

Teaching Areas: pharmacology and develomental biology

Academic/Professional Qualifications: Medical License
Professor in pharmacology


5）Projects:
1. Rho small GTPase regulates bone development
2. Wnt,Hedgehog and Notch signaling in mesenchymal stem cell differentiation

6）Publications List:
1. Wu X., Tu X., Joeng K. S., Hilton M. J., Williams D. A., Long F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008 April 18; 133 (2): 340-53.
2. Hilton M. J.*, Tu X.*, Wu X., Bai S., Zhao H., Kobayashi T., Kronenberg H. M., Teitelbaum S. L., Ross F. P., Kopan R., Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat. Med. 2008 Mar. 5; 14 (3): 306-14.
3. Wu X., Iguchi T., Itoh N., Okamoto K., Takagi T., Tanaka K., Nakanishi T. Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells. Endocrinology 2008 Jan; 149 (1):73-83.
4. Wu X., Zeng L. H., Taniguchi T., Xie Q. M. Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells. Cell Death Differ. 2007 Oct; 14(10):1792-1801.
5. Wu X., Iguchi T., Hirano J., Fujita I., Ueda H., Itoh N., Tanaka K., Nakanishi T. Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes. Biochem. Pharmacol. 2007 Oct 1; 74 (7):1020-1028.
6. Sun J. G., Deng Y. M., Wu X., Tang H. F., Deng J. F., Chen J. Q., Yang S. Y., Xie Q. M. Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma. Life Sci. 2006 Oct 26; 79 (22):2077-2085.
7. Wu X., Itoh N., Taniguchi T., Hirano J., Nakanish T., Tanaka K.. Stimulation of differentiation in sodium-dependent vitamin C transporter 2 overexpressing MC3T3-E1 osteoblasts. Biochim. Biophys. Res. Commun. 2004 May 14; 317 (4):1159-1164.
8. Wu X., Itoh N., Taniguchi T., Nakanishi T., Tetsu Y., Yumoto N., Tanaka K. Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles in osteoblast differentiation. Arch. Biochem. Biophys. 2003 Dec. 1; 420 (1):114-120.
9. Wu X., Itoh N., Taniguchi T., Nakanishi T., Tanaka K. Requirement of calcium and phosphate ions in expression of sodium-dependent vitamin C transporter 2 and osteopontin in MC3T3-E1 osteoblastic cells. Biochem. Biophys. Acta (Mol. Cell Res.) 2003 Jun 17; 1641(1):65-70.