Profile

Education and professional record：

Nov. 2015 - Present: Professor of Biochemistry, Ph.D program supervisor, Zhejiang University School of Medicine;

Sep. 2012 - Nov. 2015: Postdoctoral fellow in Yuan’s lab, Department of Cell Biology, Harvard Medical School;

Jul. 2011 - Sep. 2012: Assistant professor in Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China;

Sep. 2006 – Jul. 2011: Ph.D. in Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China;

Sep. 2002 – Jul. 2006: Bachelor of Science in Fudan University, Shanghai, China.

Research interests:

1.      Develop cell based High-Through Screening models for drugs against cancers and neurodegenerative diseases;

2.      Explore the novel mechanisms regulating autophagy, cell death and neuroinflammation.

Main publications:

1.      Yuanyuan An, Hongguang Xia* and Jie Wu*. A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines. Organic & Biomolecular Chemistry 2016, 14, 1665-1669. (IF: 3.6)

2.      Xiaolin Pan, Yong Luo, Hong-guang Xia* and Jie Wu*. A palladium-catalyzed tandem reaction of 2-(2-bromobenzylidene)cyclobutanone with 2-alkynylphenol. Chemical Communications 2015, 51, 16483-16485. (IF: 6.8)

^*Corresponding author

3.      Xiaolin Pan, He Wang, Hong-guang Xia* and Jie Wu*. An unexpected three-component reaction of 2-alkylenecyclobutanone, N'-(2-alkynylbenzylidene)hydrazide with water. RSC Advances 2015, 5, 85225-85228. (IF: 3.8)

^*Corresponding author

4.      Lorena Galan-Acosta^#, Hongguang Xia^#, Junying Yuan and Helin Vakifahmetoglu-Norberg.Activation of Chaperone-Mediated Autophagy as a potential anticancer therapy. Autophagy 2015 Nov; 11(12): 2370-2371. (IF: 11.4)

^#Co-first authors.

5.      Hong-guang Xia, Ayaz Najafov, Jiefei Geng, Xuemei Han, Lorena Galan-Acosta, Bing Shan, Yaoyang Zhang, Erik Norberg, Tao Zhang, Lifeng Pan, Junli Liu, Jonathan L. Coloff, Dimitry Ofengeim, Hong Zhu, Kejia Wu, Yu Cai, John R. Yates, Junying Yuan* and Helin Vakifahmetoglu-Norberg. Degradation of HK2 by Chaperone-Mediated Autophagy promotes Metabolic Catastrophe and Cell Death. J. Cell Biol. 2015 August; 210(5): 705-716. (IF: 9.7)

6.      Tao Zhang, Kangyun Dong^$, Wei Liang^$, Daichao Xu^$, Hongguang Xia^$, Jiefei Geng, Ayaz Najafov, Min Liu, Yanxia Li, Xiaoran Han, Juan Xiao, Zhenzhen Jin, Ting Peng, Yang Gao, Yu Cai, Chunting Qi, Qing Zhang, Anyang Sun, Marta Lipinski, Hong Zhu, Yue Xiong, Pier Paolo Pandolfi, He Li, Qiang Yu, Junying Yuan*. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.E-life. 2015 March. (IF: 8.5)

$Co-second authors

7.      Helin Vakifahmetoglu-Norberg^#, Hong-guang Xia^#, Junying Yuan*. Pharmacologic agents targeting autophagy. J. Clin. Invest. 2015 Jan; 125(1): 5-13. (IF: 13.8, Cited by 5)

^#Co-first authors.

8.      Helin V. N., Minsu K., Hong-guang Xia, Marcin P. Iwanicki, Dimitry Ofengeim, Jonathan L. Coloff, Lifeng P., Tan A. Ince, Guido Kroemer, Joan S. Brugge and Junying Yuan. Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Aug; 27(15): 1718-1730. (IF: 12.6,Cited by 21)

9.      Junli Liu^#, Hong-guang Xia^#, Lihong Zhang, Lihua Xu, Ying Li, Cai Yu, Minsu Kim, Tao Zhang, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Dawei Ma, and Junying Yuan. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13. Cell 2011 Sep; 147(1): 223-234. (IF: 33.1, Cited by 163)

^#Co-first authors.

10.Xiuquan Ma, Mingzhi Jin, Yu Cai, Hong-guang Xia, Kai Long, Junli Liu, Qiang Yu and Junying Yuan. Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy. Chemistry & Biology 2011 Nov; 18(11): 1474-1481.(IF: 6.2,Cited by 13)

11.Gang Chen, Hong-guang Xia, Yu Cai, Dawei Ma, Junying Yuan and Chengye Yuan. Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies. Med Chem Comm 2011 Feb; 2: 315-320. (IF: 2.5, Cited by 1)

12.Gang Chen, Hong-guang Xia, Yu Cai, Dawei Ma, Junying Yuan and Chengye Yuan. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers. Bioorganic & Medicinal Chemistry Letters 2011 Jan; 21(1): 234-239. (IF: 2.3, Cited by 7)

13.Wenhua Li, Shouyun Yu, Mingzhi Jin, Hong-guang Xia, Dawei Ma. Total synthesis and cytotoxicity of bisebromoamide and its analogues. Tetrahedron Letters 2011 April; 52(17): 2124–2127. (IF: 2.4, Cited by 11)

14.Hong-guang Xia, Lihong Zhang, Gang Chen, Tao Zhang, Junli Liu, Mingzhi Jin, Xiuquan Ma, Dawei Ma, and Junying Yuan. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 2010 Jan; 6(1): 61-66. (IF: 11.4, Cited by 77)

15.   Jie Wu^* and Hong-guang Xia. Tertiary amines as highly efficient catalysts in the ring-opening reactions of epoxides with amines or thiols in H₂O: expeditious approach to beta-amino alcohols and beta-aminothioethers." Green Chem. (2005) 7, 708-710. (IF: 8.0, Cited by 46)

^*Corresponding author

16.   Jie Wu^*, Hong-guang Xia and Ke Gao. Molecular iodine: a highly efficient catalyst in the synthesis of quinolines via Friedlander annulation.Org. & Biomol. Chem. (2006) 4, 126-129. (IF: 3.5, Cited by 113)

^*Corresponding author

Awards and honors:

1.      Outstanding Ph.D. thesis, Chinese Academy of Sciences (2012)

2.      Ray Wu Prize for Excellence in Biological Sciences (2011)

3.      Outstanding graduate, Chinese Academy of Sciences (2011)

4.      Outstanding graduate, Fudan University (2006)

5.      Chun-Tsung Scholar, awarded by the Chun-Tsung Foundation (2006)