Profile

Prof. Qiang-min Xie
Research Interest: Respiratory, Inflammatory and Immnuopharmacology
Deputy Director of Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, Medical Science College of Zhejiang University.
Contact：phone：86-0571-88208231（O）；15957119887（M）; E-mail：xieqm@zju.edu.cn.
Academic society:
Deputy of Chinese Antiinflammatory and Immnuopharmacology Academic Society;
Deputy of Zhejiang Physiological Academic Society;
Deputy of Zhejiang Pharmacological Academic Society;
Associate Editor of World Clinical Drug;
Reviewer of Eur J Pharmacol, Acta Pharmacol Sin, Trends in Pharmacol, J Pharm Pharmacol, etc.
Grants and Projects:
1. Molecular basis of the protein tyrosine phosphatase SHP-2 regulates smoking-induced injury of airway epithelium. The grants from the National Scientific Foundation of China (No. 30973542).
2. The Regulatory Effecfs of 5-lipooxygenase on Immuno-Neuro-Endocrine of CNS in asthma.The grants from the National Scientific Foundation of China (No. 30671919).
3. Basic Research of Respiratory Diseases and Respiratory Injury. A subproject from the National Key Project for Basic Research of China (973 Project)
4. Basic Research and Development of Cholinergic M3 Receptor Antagonists. A subproject from the National 863 Project of China.
Major Papers:
1. Zhang SJ, Deng YM, Zhu YL, Dong XW, Jiang JX, Xie QM. Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats. Respir Res. 2010;11: [Epub ahead of print]
2. Zhu YL, Zhang SJ, Deng YM, Dong XW, Jiang JX, Xie QM. Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs. J Neuroinflammation. 2010;7:12.
3. Xie YC, Dong XW, Wu XM, Yan XF, Xie QM. Inhibitory effects of flavonoids extracted from licorice on lipopolysaccharide-induced acute pulmonary inflammation in mice. Int Immunopharmacol. 2009;9(2):194-200.
4. Xie QM, Wu X, Wu HM, Deng YM, Zhang SJ, Zhu JP, Dong XW. Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats. Int Immunopharmacol. 2008;8(12):1639-45.
5. Wu X, Zeng LH, Taniguchi T, Xie QM. Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells. Cell Death Differ. 2007;14(10):1792-801.
6. Deng YM, Xie QM, Tang HF, Sun JG, Deng JF, Chen JQ, Yang SY. Effects of ciclamilast, a new PDE 4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma. Eur J Pharmacol. 2006;547(1-3):125-35.
7. Sun JG, Deng YM, Wu X, Tang HF, Deng JF, Chen JQ, Yang SY, Xie QM. Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma. Life Sci.2006;79(22):2077-85.
8. Tang HF, Chen JQ, Xie QM, Zheng XY, Zhu YL, Adcock I, Wang X. The role of PDE4 in pulmonary inflammation and goblet cell hyperplasia in allergic rats. Biochim Biophys Acta. 2006;1762(5):525-32.
Major Books:
Chief Editor:《Pharmacological Frontline—New Concept and New Drugs of Asthma and COPD》, Chinese Science Publishing Company, 2003.
Second Chief Editor: 《Experiment Course of Physiological Science》, Zhejiang University Publishing Company, 2004.
Assistant Editor: 《Clinical Pharmacology》，People’s Medical Publishing House, 2007.
Assistant Editor: 《Gerontal Pharmacology & Pharmacotherapeutics》, People’s Medical Publishing House, 2010
Assistant Editor: 《Methodology of Pharmacological Experiments》, People’s Medical Publishing House, 2010
Rewards:
Science and Technology Prize of Zhejiang Province (Second Grade)
Methodological and Pharmacological Studies of PDE4 as a New Terget for Therapy of Respiratory Diseases, 2008.
The Experimental Studies of Bacillus Calmette-Guerin and Vaccine to prevent and treat Asthma, 2005.