Profile

09/1998-07/2002  B.S. in Biology,School of Life Sciences, Xiamen University

 

01/2015-present    Associate professor, Institute of Translational Medicine, Zhejiang University

03/2008-12/2014   Postdoctoral Research Fellow, Department of Radiation Oncology, University of Michigan at Ann Arbor

 

Ribosomal proteins have been shown to play important roles in cell survival, differentiation, apoptosis, genomic stability, and other physiological processes, in additional to their primary roles in protein synthesis. The disruption of ribosomal proteins is involved in hematologic and metabolic disorders and tumorigenesis. Employing the techniques of cellular biology, molecular biology, biochemistry, histopathology and genetically engineered mouse tumor models, we will mainly study the functions of ribosomal protein S27-like (RPS27L) in the development and progression of cancer, with an ultimate goal in validation of RPS27L as a biological marker in the diagnosis and/or prognosis for human cancers.

 

1. Xiong XF#, Zhao YC#, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y*. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife 2014, 3: e02236. (#equal contribution) Recommended by Faculty of 1000

2. Xiong XF, Zhao YC, He HB, Sun Y*. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene 2011, 30(15): 1798-811.

3. Xiong XF, Li H, Cao EH*. PIG11 protein binds to DNA in sequence-independent  manner in vitro. Biochemical and Biophysical Research Communications 2007, 358: 29-34.

4. Zhao YC, Xiong XF, Jia LJ, Sun Y*. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease 2012, 3: e386.

5. Zhao YC, Xiong XF, Sun Y*. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell 2011, 44(2): 304-16.