Profile

Medical School (the highest level degree)
Zhejiang University, College of Medicine, Hangzhou, Zhejiang (M.D., Ph.D.)
Luebeck Medical University, Luebeck, Germany (Postdoctoral Training)

Academic Rank
Professor of Oncology (Chief Physician)

Interests
Personalized and comprehensive treatment of gastrointestinal carcinoma
Genetic characteristics of hereditary colorectal cancer

Professional Highlights
Member of American Society of Clincal Oncology (ASCO)
Member of Chinese Society of Clincal Oncology (CSCO)
Member of Chinese Anti-Cancer Association
Youth Committee of Colorectal Cancer Branch, Chinese Anti-Cancer Association
Committee of Chemotherapy Branch, Zhejiang Anti-Cancer Association
Committee of Tumor Marker Branch, Zhejiang Anti-Cancer Association
Committee of Zhejiang Immunology Assocoation
Youth Committee of Cancer Branch, Zhejiang Medical Association

Awards
The Southern California Society of Colon and Rectal Surgeons Award, 1997
The First Class of Science and Technology Award of Zhejiang Province, 2002
The Second Class of National Science and Technology Award, 2005
The Third Class of Science and Technology Award of Zhejiang Province, 2005
The Youth Science and Technology Award of Zhejiang Province, 2011


Publications
1.Han HJ, Yuan Y, Ku JL,et al. Germline Mutations of hMLH1 and hMSH2 Genes in Korean Hereditary Nonpolyposis Colorectal Cancer. J Natl Cancer Inst 1996;88(18):1317-1319.
2.Yuan Y, Zhang SZ, Zheng S, et al. Relationship of expression of c-erb-B2, p53, ER and PR proteins and prognosis in axillary lymph node negative breast cancer patients. Tumor 16(6):583-586.
3.Yuan Y, Kim WH, Han HS, et al. Establishment and Characterization of Human Ovarian Carcinoma Cell Lines. Gynecology Oncology 1997;66:378-387.
4.Yuan Y, Kim WH, Han HS, et al. Establishment and Characterization of Cell Lines Derived from Uterine Malignant Mixed Mullerian Tumor. Gynecology Oncology 1997;66:464-474.
5.Zhang SZ, Yuan Y，et al. Prognostic significance of molecular markers in axillary lymph node negative breast cancers. Chinese J Surgery 1997;35(8):475-477.
6.Yuan Y, Zheng S. Human mismatch repair genes and hereditary nonpolyposis colorectal cancer. Chinese J Clinical Oncology 1997; 24(4):298-300.
7.Yuan Y, Han HJ, Zheng S, et al. Germiline Mutations of hMLH1 and　hMSH2 Genes in Patients With Suspected Hereditary Nonpolyposis Colorectal Cancer and Sporadic Early-onset Colorectal Cancer. Dis Colon Rectum 1998;41(4):434-440.
8.Park JG, Yuan Y. Genetic identification and management of hereditary nonpolyposis colorectal cancer (Review). Int J Oncology 1998;12(4):947-955.
9.Yuan Y，Zheng S. Clinical diagnosis and treatment of hereditary nonpolyposis colorectal cancer. (review) J Practical Oncology 1998; 13(4):253-255.
10.Wang X，Zhang SZ, Yuan Y, et al. Prognostic prediction of S-phase fraction in axillary node-negative breast cancer. J Practical Oncology 1998; 13(5):283-285.
11.Yuan Y, Huang J, Zheng S. Mutation of human mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) families. Chin J Oncology 1999;21(2):105-107.
12.Yuan Y, Zheng S. Mutations of hMLH1 and hMSH2 genes in suspected hereditary nonpolyposis colorectal cancer. Natl Med J China 1999;79(5):346-348.
13.Yuan Y, Zheng S. Genetic basis of hereditary nonpolyposis colorectal cancer. Chin J Exp Surg 1999 ;16(3):288-289.
14.Zhang SZ, Jin RX, Zheng BY, Chen LR, Peng JP, Yuan Y. Prognosis of occult axillary lymph node metastasis in breast cancer patients. Tumor 1999; 19(2):104-106.
15.Zhang X, Shen YC, Huang CG, Yuan Y, et al. Telemerase activity of exfoliated cells from nipple discharge. Chin J Lab Diagn 1999; 3(6): 259-260.
16.Zhang X, Ying KJ, Cai XH, Yuan Y, Zheng S. Detection of telomerase activity in bronchoscopic brushing cells of lung cancer patients. Chinese J Cancer Research 1999,11(2): 136-138.
17.Maacke H, Jost K, Opitz S, Miska S, Yuan Y, Hasselbach L, Luttqes J, Kalthoff H, Sturzbecher HW. DNA repair and recombination factor Rad51 is over-expressed in pancreatic adenocarcinoma. Oncogene 2000;19:2791-2795.
18.Yuan Y. Researches on hereditary nonpolyposis colorectal cancer. (review) J Practical Oncology 2000; 15(6):427-428,432.
19.Yuan Y, Zhang SZ, Zheng S. Selecting criteria of Chinese hereditary colorectal cancer. Chin J Oncology 2004;26(2):191-192.
20.Yuan Y, Ye J, Zheng S. Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families. Chinese Med J 2004;117(5):748-752.
21.Cao WM, Yuan Y, Song YM, et al. Clinical features and mutation analysis of a poly-(A)~8 tract in M3 cholinergic receptor gene in Chinese HNPCC families. J Zhejiang Univ (Medical Sciences) 2004;33(5):399-402.
22.Song YM, Yuan Y, Zheng S. Hypermethylation of hMLH1 promoter in sporadic colorectal cancer. J Zhejiang Univ (Medical Sciences) 2004;33(5):395-398.
23.Yuan Y, Ye J, Dong Q, et al. Structural characterization of 5'-flanking regulatory region of DNA repair gene Rad51. Chin J Med Genet 2004; 21(3):248-251.
24.Yuan Y, Huang YQ, Cai SR, Song YM, Zheng S, Zhang SZ. Genetic characterization of chinese hereditary non-polyposis colorectal cancer by DHPLC and multiplex PCR. Jpn J Clin Oncol 2004;34(11): 660-666.
25.Huang YQ, Yuan Y, Wang YP, et al. Large genomic deletions of mismatch repair genes in Chinese patients with hereditary nonpolyposis colorectal cancer. Chin J Med Genet 2005;22(1):88-90.
26.Fu JF, Yuan Y. Advances in the treatment of non-small cell lung cancer by Iressa. Foreign Med Sci (Oncol Sect) 2005; 32(3):205-208.
27.Huang YQ, Yuan Y, Zhang SZ, et al. Mutations of mismatch repair genes in Chinese hereditary nonpolyposis colorectal cancer. Chinese J Surgery 2005;43(5):317-320.
28.Zheng S, Huang YQ, Yuan Y. Hereditary colorectal cancer in China. Hereditary Cancer in Clinical Practice 2005;3(4):155-164.
29.Zhu M, Liu XR, Huang YQ, Yuan Y, Li JT, Zhang XM, Zhang YY, Wang YP. The analysis for identifying large DNA fragment aberrations of MSH2 and MLH1 genes from familial colorectal cancer in China. Chinese J Medical Genetics 2005;22(6):603-606.
30.Yuan Y, Cao WM, Cai SR, et al. Clinical phenotype of Chinese hereditary nonpolyposis colorectal cancer (HNPCC) families. Chinese J Oncology 2006;28(1):36-38.
31.Shen H, Huang JJ, Yuan Y. Detection of the activity of lymphocyte and Th1/Th2 cytokines of patients with malignant tumor. Zhejiang Practical Medicine 2006;11(1):3-5.
32.Shen H, Huang JJ, Yuan Y. Clinical study of 50 patients with stage IV non-small cell lung cancer treated by NP and MVP scheme. Zhejiang Practical Medicine 2006;11(3):158-159.
33.Wang XL, Yuan Y, Zhang SZ, Cai SR, Huang YQ, Jiang Q, Zheng S. Clinical and genetic characterization of Chinese hereditary nonpolyposis colorectal cancer families. World J Gastroenterol 2006;12(25):4074-4077.
34.Peng XD, Fu JF, Yuan Y. Comparative analysis of clinicopathologic features of gastric cancinoma in the old and young patients. J Int Oncology 2007;34(6):473-476.
35.Huang YQ, Yuan Y, Zhang SZ, Zheng S. Analysis of criteria specific overall survival in 102 Chinese colorectal cancer patients with familiy history. The 2nd Biennial scientific meeting of International Society for Gastrointestinal Hereditary Tumors. Yokohama, Japan, March 27-30, 2007.
36.Yuan Y, Huang YQ, Zhang SZ, Zheng S. Screening hereditary nonpolyposis colorectal cancer from colorectal cancer with microsatellite instability in Chinese populations. The 2nd Biennial scientific meeting of International Society for Gastrointestinal Hereditary Tumors. Yokohama, Japan, March 27-30, 2007.
37.Shen H, Yuan Y, Song YM, et al. Comparison of clinical and genetic phenotypes between Chinese and Korean HNPCC families. Chin J Med Genet 2008;25(3):326-330.
38.Li FM, Yuan Y. The relationship of tumor response and the changes of tumor markers before and after chemotherapy in advanced non-small cell lung cancer patients. Zhejiang Practical Medicine 2008;13(6):400-401.
39.Fu JF, Wang S, Yuan Y. Researcher on young gastric cancer. Zhejiang Med 2009;31(7):1038-1040.
40.Shen H, Zhong X, Ge XQ, Huang HJ, Yuan Y. Surgical resection of lung adenocarcinoma without EGFR mutation after neoadjuvant gefitinib treatment.Clin Respir J 2010; 4(3): 192-193
41.Shen H, Yuan Y, Hu HG, Zhong X, Ye XX, Li MD, Fang WJ, Zheng S. Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients. World J Gastroenterology 2011;17(6):809-816
42.Yuan Y, Shen H, Hu XY, Gu FY, Li MD, Zhong X. Multidisciplinary treatment with chemotherapy, targeted drug, and high-intensity focused ultrasound in advanced pancreatic carcinoma. Med Oncol. 2012;29(2):957-961.
43.Pan M, Cong P, Wang Y, Lin C, Yuan Y, Dong J, Banerjee S, Zhang T, Chen Y, Zhang T, Chen M, Hu P, Zheng S, Zhang J, Qi M. Novel LOVD Databases for Hereditary Breast Cancer and Colorectal Cancer Genes in the Chinese Population. Human Mutation 2011;32(12):1335-1340.
44.Song Y, Li M, Shan J, Ye X, Tang S, Fang X, Ding K, Yuan Y. Acute small bowel obstruction: a rare initial presentation for the metastasis of the large-cell carcinoma of the lung. World Journal of Surgical Oncology 2012, 10:26 (29 January 2012)
45.Yuan Y, Tan CW, Shen H, Yu JK, Fang XF, Jiang WZ, Zheng S. Identification of the Biomarkers for the Prediction of Efficacy in First-Line Chemotherapy of Metastatic Colorectal Cancer Patients using SELDI-TOF-MS and Artificial Neural Networks. Hepatogastroenterology. 2012 Apr 12;59(120). doi: 10.5754/hge12127. [Epub ahead of print]
46.Li XF, Li MD, Shen H, Fang XF, Huang PT, Yuan Y（通讯作者）. Evaluation of Therapeutic Effect of Tumor-Targeted Therapy. Onco Targets Ther. 2012;5:191-198.
47.Hu H, Zhang H, Ge W, Liu X, Loera S, Chu P, Chen H, Peng J, Zhou L, Yu S, Yuan Y, Zhang S, Lai L, Yen Y, Zheng S. Secreted Protein Acidic and Rich in Cysteines-like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal Cancers. Clin Cancer Res. 2012 Oct 1;18(19):5438-48. doi: 10.1158/1078-0432.CCR-12-0124. Epub 2012 Aug 13
48.Han X, Fang X, Lou X, Hua D, Ding W, Foltz G, Hood L, Yuan Y（通讯作者）, Lin B. Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients. PLoS One. 2012;7(8):e41335. Epub 2012 Aug 17.
49.Yuan Y, Tan CW, Li MD, Shen H, Fang XF, Hu YH, Ma SL. Activity of pemetrexed and high dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib. World Journal of Surgical Oncology 2012 Nov 7; 10(1):235