Profile

Dan Zhang , Ph.D. M.D.

Chief Physician, Associate Professor,
Vice President, Women's Hospital, School of Medicine, Zhejiang University, 
Assistant Director, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University, 
Address: 1# Xueshi Road, Hangzhou, 310006, P.R.China
Email: zhangdan@zju.edu.cn
Tel: 86-571-89991008
Key member of the 2011 “Changjiang scholars and innovative research team” from Ministry of Education, the talent of the second level 151 Talent Project of Zhejiang Province, the Distinguished Young Doctor of Zhejiang Province, Key member of Major Research Project of the National Science, the consultant expert of the Quality Control Center in Reproduction of Zhejiang Province.
 
Education Background
1994.9-2001.7   7-year program of medicine, Master of Medicine, Zhejiang University.
2007.9-2011.3  Obstetrics and Gynecology, Doctor of Medicine, Zhejiang University.
2011.9-2011.12  Visiting Scholar, the Southampton University Hospital, and the Poole Hospital, the United Kingdom.

2016.9-2016.12  Visiting Scholar, University of California, Los Angeles(UCLA).

2017.11-  Visiting Scholar，Brigham and Women’s Hospital

Professional Career
2001.8-2003.8  Resident Doctor, Women's Hospital, School of Medicine, Zhejiang University.
2003.9-2009.11  Attending Physician, Women's Hospital, School of Medicine, Zhejiang University.
2009.12-2015.11  Associate chief physician, Women's Hospital, School of Medicine, Zhejiang University.
2012.4-2014.1  Attending, the Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University.
2013.2-2014.1  Vice Director, the Office of International Affairs, Women's Hospital, School of Medicine, Zhejiang University.
2014.2-  Director, the Third Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University.

2015.11-  Assistant Director, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University.
2015.12-  Chief Physician, Women's Hospital, School of Medicine, Zhejiang University.
2016.1-2016.12 Assistant Dean, the Sci-Tech Academy of the Zhejiang University.
2016.6-2017.9 Assistant President, Women's Hospital, School of Medicine, Zhejiang University.

2017.9-  Vice President, Women's Hospital, School of Medicine, Zhejiang University.

Research Areas of Expertise and Interests
1. The genetic mapping, mutation identification and the molecular mechanism of endocrine diseases.
2. Ovarian aging and fertility maintenance.
3. The physiology and regulation of human reproduction.
4. Epigenetic influences of assisted reproductive technology in gametes, embryo, fetus and offsprings.
5. Translational medicine and personalized medicine. 

Honors
1. The First Prize of Science and Technology Achievement Awards, Maternal and Child Health Studies of China (2015)

2. The Second Prize of Science and Technology Progress Awards, Zhejiang Province (2016)
3. The First Prize of Excellent Thesis Presentation, the Youth Forum in 2013 Annual Meeting of the Chinese Society of Reproductive Medicine.
4. Outstanding Young Doctor Award of Zhejiang Province (2013).
5. Outstanding Young Researcher Award of Integrative Medicine of Jiangsu and Zhejiang Province (2013).
6. Outstanding Young Researcher Award of the Chinese Medical Association Branch of Reproductive Medicine (2013).
7. The Talent of the Third Level 151 Talent Project of Zhejiang Province(2013).
8. Liu Tianxiang Prize of Women's Hospital, School of Medicine, Zhejiang University (2013).
9. The Outstanding Paper award, 2014 Annual Meeting of the Chinese Society of Reproductive Medicine.

10.Member of Clinical Medicine Famous Master Plan of Zhejiang University (2014). 
11. The Outstanding Class Teacher of Blue Land, Qiushi College of Zhejiang University (2014) .
12. The Outstanding Class Teacher of Qiushi College of Zhejiang University (2014).
13. The Third Prize of Young Teacher Teaching Competition of Zhejiang University (2015).
14. The Outstanding Party Member of Women's Hospital, School of Medicine, Zhejiang University (2016).

15.The Outstanding Party Member of Zhejiang University (2016).

16.The Outstanding Class Teacher of Medical School of Zhejiang University (2016).

17. The Outstanding Class Teacher of Zhejiang University (2016). 

18. The Talent of the Second Level 151 Talent Project of Zhejiang Province (2016).

19. Excellent reproductive endocrinology doctor most trusted by the people of Zhejiang Province (2017).

20. The Outstanding Class Teacher of Zhejiang University (2017).

Patent (in China)
A traditional Chinese medicine composition with effect of improvement of ovarian response and its application.(Patent number: 201110098135.2)
A traditional Chinese medicine composition with effect of relief of anxiety and its application.(Patent number: ZL 2014 1 0059567.6)

Professional Activities
Editorial Board Member, Scientific Reports
Guest Editor, BioMed Research International
Reviewer, Endocrinology

Reviewer, JCEM
Permanent Council, Society of reproductive medicine, Association for Maternal and Child Health Studies of China

Vice Chairman, the Reproductive Medicine Committee, the Chinese Association of Integrative Medicine

Vice Chairman , Reproductive Health Committee, Maternal and Child Health Care of China Association

Vice Chairman, Youth Commission, the Chinese Society of Reproductive Medicine
Committee Member, Youth Commission, the Gynecological and Obestetric Committee, the Chinese Association of Integrative Medicine

Committee Member, Youth Commission, Reproductive Medicine Branch, Chinese Medical Association. 

Committee Member, Reproductive Medicine, Chinese Medical Association for the international promotion of health.

Member of a Council, Zhejiang Women’s Association for Science and Technology.

Vice Chairman, the Reproductive Medicine Committee, Zhejiang Province Association of Integrative Medicine.

Vice Chairman, the Society of Reproductive Medicine in Zhejiang Province
Committee member, the Society of Reproductive Medicine in Zhejiang Province.

Vice Chairman, Youth Commission, Society of Obstetrics and Gynecology of Zhejiang Medical Association.
Panel Member Expert, the Assisted Reproduction Quality Control Center of Zhejiang Province
Examiner of RCOG in Chinese test
Class Teacher of Class 1310, Clinical Medicine, School of Medicine, Zhejiang University 

Membership, the American Society for Reproductive Medicine
Membership, the European Society of Human Reproduction and Embryology

Grant Reviewer:
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Natural Science Foundation of the Science and Technology Department of Zhejiang Province

Grant Support:

Title:       Malat1-mediated effects and mechanisms of excessive AMH on the development of PCOS.
Agency:    National Natural Science Foundation of China
No. :       81771535
Role:       Principal Investigator
Period:      01/01/2018-31/12/2021

Title:       The role and mechanism of FHL protein family in physiological decline of ovarian function.

Agency:    Zhejiang Provincial Natural Science Foundation

No. :       LZ18H040001

Role:       Principal Investigator

Period:      01/01/2018-31/12/2021

Title:       Construction and Application of Key Technology System for Regeneration and Repair of Uterus.

Agency:    Zhejiang Provincial Health and Family Planning Commission

No. :       WKJ-ZJ-1826

Role:       Principal Investigator

Period:      01/01/2018-31/12/2020

Title:       The mechanism of BNC1 regulating the oocytogenesis, oocyte development, apoptosis and atresia.
Agency:    National Natural Science Foundation of China
No. :       81471421
Role:       Principal Investigator
Period:      01/01/2015-31/12/2018
Title:       Gene mapping and mutation identification of hereditary premature ovarian failure
Agency:    National Natural Science Foundation of China
No. :       81270664
Role:       Principal Investigator
Period:      01/01/2013-31/12/2016
Title:       The role and the molecular mechanism of FSH-FSHR in the endometrial physiological atrophy
Agency:    National Natural Science Foundation of China
No. :       81170310
Role:       Principal Investigator
Period:      01/01/2012-31/12/2015
Title:       The mechanism of BNC1 mutation in the hereditary premature ovarian failure.
Agency:    Zhejiang Provincial Natural Science Foundation for Distinguished Young Scientists
No. :       LR14H040001
Role:       Principal Investigator
Period:      01/01/2014-31/12/2017

Title:      Evaluation of the effectiveness and safety of different subtypes of PCOS interventions using model animals. 

Agency:    National Key Research and Development Program of China
No.:        2017YFC1001003
Role:       Key Investigator Member
Period:      01/07/2017-31/12/2021
Title:      The correlation and mechanism of reproductive stem cells transformation and the diseases of abnormal sex differentiation. 

Agency:    National Basic Research Program of China (973 Program)
No. :       2013CB967404
Role:       Key Investigator Member
Period:      01/01/2013-31/12/2017
Title:       The effect of ovarian hyper-stimulation on the offspings' imprinted genes and its trans-generational influence
Agency:    National Natural Science Foundation of China
No. :       30901604
Role:       Principal Investigator
Period:      01/01/2010-31/12/2012
Title:       The role and mechanism of FSHR and downstream signal pathway in the menopausal adipose proliferation and differentiation.
Agency:    Provincial Natural Science Foundation of Zhejiang
No. :       Y2090151
Role:       Principal Investigator
Period:      01/01/2010-31/12/2011
Title:       The establishment of technological system preventing iatrogenic multiple pregnancy and improving the quality of birth population
Agency:    the Science and Technology Special Project of Zhejiang Province
No. :       2010C33167
Role:       Principal Investigator
Period:      01/01/2010-31/12/2012
Title:       The translational regulation and following pathway of FSH in the endometrial cell apoptosis and tissue atrophy.
Agency:    the Fundamental Research Funds for the Central Universities
No. :       2011FZA7020)
Role:       Principal Investigator
Period:      01/09/2011-31/09/2012
Title:       The regulation and mechanism of FSH on endometrial atrophy.
Agency:    Excellent Young Scientists Foundation of the Health Department of Zhejiang Province
No. :       2011RCA028
Role:       Principal Investigator
Period:      01/06/2011-31/12/2013
Title:       The role of aquaporins in human embryo implantation and early pregnancy loss.
Agency:    Scientific Funding of the Health Department of Zhejiang Province
No. :       2009B100
Role:       Principal Investigator
Period:      01/06/2009-31/12/2011
Title:       The role of obesity in the IVF-ET outcomes for.
Agency:    Population and Family Planning Science and technology project of Zhejiang Province
No. :       200887
Role:       Principal Investigator
Period:      01/09/2008-31/12/2010

Publications
First Author* or Corresponding Author# :
1. Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med. 2018 Jan 11;378(2):126-136.

2. Chen XJ, Chen F, Lv PP, Zhang D, Ding GL, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018; 61:72-79.

3. Liu F, Liu YF, Liu J, Huang Y, Xu GF, Cai J, Chen Y, Wu YQ, Ying YY, Zhang RJ, Zhang D#. Effect of different anesthesia on the reproductive and obstetric outcomes of heterotopic pregnancies. International Journal of Obstetric Anesthesia. DOI: 10.1016/j.ijoa.2017.12.001.

4. Xu GF，Liao Y，Li JY，Liu YF，Huang Y，Wu YQ，Liu J，Lv PP，Zhang RJ，Zhang D#. Ovarian stimulation perturbs methylation status of placental imprinting genes and reduces blood pressure in the second generation offspring，European Journal of Obstetrics & Gynecology and Reproductive Biology，2017.2.22，211（2017）：140~145

5. Sun YX*, Zhang YX*, Zhang D*, Xu CM, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet. 2017, 136(2):1-13.

6. Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D#, Huang HF#. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016 Nov 9;6:36805. 

7. Zhu L, Zhang Y, Liu Y, Zhang R, Wu Y, Huang Y, Liu F, Li M, Sun S, Xing L, Zhu Y, Chen Y, Xu L, Zhou L, Huang H#, Zhang D#. Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study. Sci Rep. 2016 Oct 20;6:35141.

8. Zhang D*#, Xu GF*, Zhang RJ, Zhu YM, Gao HJ, Zhou C, Sheng JZ, Huang HF#. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. Reprod Fertil Dev. 2016, 28(4): 499-506.

9. Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, Zhou JH, Huang HF. Follicle-Stimulating Hormone Induces Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism. J Clin Endocrinol Metab. 2016; 101: 254–263

10.Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL, Lv PP, Leung PC, Huang HF. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. Curr Mol Med. 2016;16(3):299-311. 

11.Yang J*, Zhang D*, Yu Y, Zhang RJ, Hu XL, Huang HF, Lu YC. Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway. Cell Cycle. 2015, 14(20):3318-3330. 

12.Huang YT, Zhou J, Shi S, Xu HY, Qu F, Zhang D, Chen YD, Yang J, Huang HF, Sheng JZ. Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer. Sci Rep. 2015 Jul 29;5:12484.

13.Zhang D*, Li J*, Xu G, Zhang R, Zhou C, Qian Y, Liu Y, Chen L, Zhu B, Ye X, Qu F, Liu X, Shi S, Yang W, Sheng J, Huang H. Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway. Aging Cell. 2015 Apr;14(2):284-7. 

14.Zhang D*, Zhang Z, Lv PP, Liu Y, Li JY, Xu GF, Zhang RJ, Chen SC, Qian YQ, Zhu LL, Ye XQ, Bo XS, Shi YY, Sheng JZ, Huang HF. Whole-exome sequencing identifies mutations in basonuclin 1 as a cause of premature ovarian failure, Human Reproduction. 2015, Suppl 1: p115-p115.

15.Jiang SW, Brost B, Zhang D, Ren CE. Aberrant Gene Regulation in Obstetric, Gynecologic, and Reproductive Diseases. Biomed Res Int. 2015:187691. 

16.Xu GF, Zhang JY, Pan HT, Tian S, Liu ME, Yu TT, Li JY, Ying WW, Yao WM, Lin XH, Lv Y, Su WW, Ye XQ, Zhang FH, Pan JX, Liu Y, Zhou CL, Zhang D, Liu XM, Zhu YM, Sheng JZ, Huang HF. Cardiovascular dysfunction in offspring of ovarian hyperstimulated women and effects of estradiol and progesterone: a retrospective cohort study and proteomics analysis. J Clin Endocrinol Metab. 2014 Dec;99(12):E2494-503.

17.Lv PP, Meng Y, Lv M, Feng C, Liu Y, Li JY, Yu DQ, Shen Y, Hu XL, Gao Q, Dong S, Lin XH, Xu GF, Tian S, Zhang D, Zhang FH, Pan JX, Ye XQ, Liu ME, Liu XM, Sheng JZ, Ding GL, Huang HF. Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study. BMC Med. 2014 Dec 16;12(1):240. 

18.Lu YC, Yang J, Ding GL, Shi S, Zhang D, Jin L, Pan JX, Lin XH, Zhu YM, Sheng JZ, Huang HF. Small-Conductance, Calcium-Activated Potassium Channel 3 (SK3) Is a Modulator of Endometrial Remodeling During Endometrial Growth. J Clin Endocrinol Metab. 2014 Oct;99(10):3800-10.

19.Zhu B, Xu GF, Liu YF, Qu F, Yao WM, Zhu YM, Gao HJ, Zhang D#. Heterochronic bilateral ectopic pregnancy after ovulation induction. J Zhejiang Univ Sci B. 2014 Aug;15(8):750-5. 

20.Liu AX, Shi HY, Cai ZJ, Liu A, Zhang D, Huang HF, Jin HM. Increased risk of gonadal malignancy and prophylactic gonadectomy: a study of 102 phenotypic female patients with Y chromosome or Y-derived sequences. Hum Reprod. 2014 Jul;29(7):1413-9. 

21.Hu XL, Feng C, Lin XH, Zhong ZX, Zhu YM, Lv PP, Lv M, Meng Y, Zhang D, Lu XE, Jin F, Sheng JZ, Xu J, Huang HF. High maternal serum estradiol environment in the first trimester is associated with the increased risk of small-for-gestational-age birth. J Clin Endocrinol Metab. 2014 Jun;99(6):2217-24. 

22.Qu F*, Zhang D*, Chen LT, Wang FF, Pan JX, Zhu YM, Ma CM, Huang YT, Ye XQ, Sun SJ, Zheng WJ, Zhang RJ, Xu J, Xing LF, Huang HF. Auricular Acupressure Reduces Anxiety Levels and Improves Outcomes of in Vitro Fertilization: A Prospective, Randomized and Controlled Study. Scientific Reports. 2014 May 22;4:5028. 

23.Liu XM, Zhang D, Wang TT, Sheng JZ, Huang HF. Ion/water channels for embryo implantation barrier. Physiology. 2014 May;29(3):186-95. 

24.Bao L, Chen H, Jong U, Rim C, Li W, Lin X, Zhang D, Luo Q, Cui C, Huang H, Zhang Y, Xiao L, Fu Z. Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer. Sci China Life Sci. 2014 Feb;57(2):263-8.

25.Rim CH, Fu Z, Bao L, Chen H, Zhang D, Luo Q, Ri HC, Huang H, Luan Z, Zhang Y, Cui C, Xiao L, Jong UM. The effect of the number of transferred embryos, the interval between nuclear transfer and embryo transfer, and the transfer pattern on pig cloning efficiency. Anim Reprod Sci. 2013 Dec;143(1-4):91-6. 

26.Zhou J, Huang Y, Li L, Zhu L, Zhang D, Zhang S, Chen Y. Identification of two novel, alternatively spliced mRNA transcripts of the human follicle-stimulating hormone receptor. Mol Reprod Dev. 2013 Nov;80(11):916-23.

27.Wang TT, Ke ZH, Song Y, Chen LT, Chen XJ, Feng C, Zhang D, Zhang RJ, Wu YT, Zhang Y, Sheng JZ, Huang HF. Identification of a mutation in GDF9 as a novel cause of diminished ovarian reserve in young women. Hum Reprod. 2013 Sep;28(9):2473-81. 

28.Tan YJ, Xiong Y, Ding GL, Zhang D, Meng Y, Huang HF, Sheng JZ. Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation. Fertil Steril. 2013 Apr;99(5):1428-35. 

29.Zou LB, Shi S, Zhang RJ, Wang TT, Tan YJ, Zhang D, Fei XY, Ding GL, Gao Q, Chen C, Hu XL, Huang HF, Sheng JZ. Aquaporin-1 plays a crucial role in estrogen-induced tubulogenesis of vascular endothelial cells. J Clin Endocrinol Metab. 2013 Apr;98(4):E672-82. 

30.Xiong Y, Tan YJ, Xiong YM, Huang YT, Hu XL, Lu YC, Ye YH, Wang TT, Zhang D, Jin F, Huang HF, Sheng JZ. Expression of aquaporins in human embryos and potential role of AQP3 and AQP7 in preimplantation mouse embryo development. Cell Physiol Biochem. 2013;31(4-5):649-58. 

31.Zhang D*, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Mol Aspects Med. 2012 Oct-Dec;33(5-6):676-90. 

32.Ding GL; Wang FF; Shu J; Tian S; Jiang Y; Zhang D; Wang N; Luo Q; Zhang Y; Jin F; Leung Peter C. K.; Sheng JZ; Huang HF. Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia. DIABETES, 2012.61 (5): 1133-1142.

33.Liu XM, Ding GL, Jiang Y, Pan HJ, Zhang D, Wang TT, Zhang RJ, Shu J, Sheng JZ, Huang HF. Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure. J Clin Endocrinol Metab. 2012 Oct;97(10):3672-83.

34.Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF. Small-conductance calcium-activated K(+) channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod. 2012 May;27(5):1421-30.

35.Zhang D*, Lv P*, Zhang R, Luo Q, Ding G, Yin L, Li J, Xu G, Qu F, Sheng J, Huang H. A new model for embryo implantation: coculture of blastocysts and Ishikawa cells. Gynecol Endocrinol. 2012 Apr;28(4):288-92. 

36.Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ, Huang HF. Functional expression of large-conductance calcium-activated potassium channels in human endometrium: a novel mechanism involved in endometrial receptivity and embryo implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53. 

37.Zhang D*, Xu G, Li JY, Zhu YM, Qu F, Sheng JZ, Huang HF. FSH directly down-regulated human endometrial AQP8, and resulted in decreased endometrial receptivity via disregulation of endometrial receptive factors, including LIF and OLFM1. Fertility and Sterility, Volume 96, Issue 3, Supplement, September 2011, Page S279.

38.Feng C, Tian S, Zhang Y, He J, Zhu XM, Zhang D, Sheng JZ, Huang HF. General imprinting status is stable in assisted reproduction-conceived offspring. Fertil Steril. 2011 Dec;96(6):1417-1423

39.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, Sheng JZ, Huang HF. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 2011 Sep;96(9):E1399-408. 

40.Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod. 2010 Jun;25(6):1441-50. 

41.Zhang D*, Zhu Y, Gao H, Zhou B, Zhang R, Wang T, Ding G, Qu F, Huang H, Lu X. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women. Gynecol Endocrinol. 2010 May;26(5):325-32.

42.Ding ZM, Zhang D#, Ying WW, Wang JM. Sonographic value in diagnosis of hemorrhagic ovarian cysts, Euro J Gynae Onco. 2010; 31(1):87-89.

43.Zhang D*, Xu G, Zhang RJ, Zhu YM, Sheng JZ, Huang HF. Ovarian stimulation makes a disruption of imprinting genes of mouse oocyte and placenta. Fertil Steril. 2010,94（4），Suppl 1：S155. 

44.Zhang D*, Lv PP, Ding GL, Zhang RJ, Zou LB, Xu G.F, Gao HJ, Zhu YM, Sheng JZ, Huang HF. Ovarian stimulation negatively affects the embryo-adhesion partly through the down-regulation of AQP1, AQP2 and AQP8 in endometrium. Hum Reprod. 2010 , 25 ( Suppl 1) i234：p303. 

45.Zhang D*, Ding ZM, Qian JH, Xie X, Wang Y. Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms, Euro J Gynae Onco. 2008; 29(4):390-392.

Presentation at the International Conferences: 

Effects and mechanisms of a novel mutation in basonuclin 1 gene on premature ovarian insufficiency. (2017 ESHRE Annual Meeting.)

Whole-exome sequencing identifies mutations in basonuclin 1 as a cause of premature ovarian failure. (2015 ESHRE Annual Meeting.)

FSH directly down-regulated human endometrial AQP8, and resulted in decreased endometrial receptivity via disregulation of endometrial receptive factors, including LIF and OLFM1.  (2011 ASRM Annual Meeting.)
Ovarian stimulation makes a disruption of imprinting genes of mouse oocyte and placenta. (2010 ASRM Annual Meeting.)
Ovarian stimulation negatively affects the embryo-adhesion partly through the down-regulation of AQP1, AQP2 and AQP8 in endometrium. (2010 ESHRE Annual Meeting.)
The effect of high and low BMI on outcomes of ovarian stimulation and in vitro fertilization: A retrospective study of 3691 Chinese women. (2009 ASRM Annual Meeting.)

Published Book Chapters
Zhang D. Chapter 6. In: Gamete and Embryo-Fetal Origins of Adult Diseases. Springer. 2013.10 
Zhang D. Chapter of Reproduction In: 100 questions concerning the second pregnancy. Zhejiang University. 2015.01
Zhang D. Chapter17 . In: Cesarean Scar Pregnancy. 2016.01

Zhang D. Chapter in : Guidelines for Implementation of in Vitro Fertilization and Embryo Transfer Technology. 2018.01

Zhang D. Chapter in:Encyclopedia of Reproduction, 2nd Edition. Elsevier. 2018.02