Profile

Education:
1982-1986 Qinghai Normal University Department of Biology, Xining, Qinghai Province, China. B.S.
Major: General biology.
1990-1993 Shanghai Medical University Department of Medical Genetics, Shanghai, China. Master of Science.
Major: Medical Genetics. The main research was biochemical genetics and somatic genetics on Wilson disease. Supervisor: Prof. CHEN Xiu-Zhen.
1993-1996 Fudan University, State Key Lab of Genetic Engineering, Institute of Genetics, Shanghai, China. PhD.
Major: Genetics. The main research was the polymorphism of HLA-DQA1、HLA-DQB1 genes in Han, Uygur and Kazak Chinese, and the association analysis of systemic lupus erthymatosus. Supervisor: Prof. GENG Zhen-Cheng.

Positions held and Professional Experience:
1986-1990 Teacher, Delingha No. 2 Middle School, Delingha, Qinghai Province, China.
1996-1998 Postdoctoral fellow, State Key Lab of Medical Neurobiology, Shanghai Medical University, Shanghai, China.
The main research was the role of arrestins in the desensitization of opioid receptor. PI: Prof. MA Lan.
1998-1999 Associate Professor, State Key Lab of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai, China.
The main research was cloning the novel human genes. PI: Prof. YU Long.
1999-2004 Associate Professor, Professor, PI, Director, Department of Genetics, School of Medicine, Ningbo University, Ningbo, Zhejiang Province, China.
The main researches were mapping the schizophrenia and other mental illness susceptibility genes, screening the gene mutations of some genetic disorders such as male infertility, epidermolysis palmoplantar keratoderma, etc.
2004-Present Professor, PI, Vice-Chair of Department of Biochemistry and Genetics, School of Medicine, Associate-director of Institute of Cell Biology, Zhejiang University, Hangzhou, Zhejiang Province, China.
The main researches were preimplantation genetic diagnosis and mouse model of epidermolysis palmoplantar keratoderma, screening the gene mutations of some genetic disorders such as Stargardt disease-3, isolated ectopia lentis, Hirschsprung disease, spinal muscular atrophy-1 (SMA-1), retinoblastoma, etc.
Aug. 2007- Oct. 2007 Visiting scholar, David Geffen School of Medicine, UCLA, USA.
To study the organization and teaching activities of the block-based curriculum for the first- and second- year medical students at UCLA, school of medicine.
Jan. 2008- Mar. 2008 Visiting scholar (sponsored by Pao Yu-Kong and Pao Zhao-Long Scholarship For Chinese Students Studying Abroad), Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California, Irvine USA.
To study molecular and mitochondrial medicine and genetics. PI: Prof. Douglas C Wallace.

Positions at academic societies:
Aril 2013 -, Secretary-general, China Healthy Birth Science Association.
Nov. 2009 -, Committee member, Chinese Society for Cell Biology, Medical Cell Biology Branch.
Sep. 2010 - Aril 2013, Committee member, Chinese Society of Medical Genetics.

Honors and Awards:
1995 The Awards of Advancement in Science and Technology of Shanghai, 2nd Class.
1997 The first class Guanghua Scholarship, Fudan University.
2000 Excellent Science Research Paper Prize for Young Scholars by Shanghai Science and Technology Society, 2nd Class.
2001 KC Wong Education Awards of Ningbo University.
2003 Educational Achievement Awards of Ningbo, 1st Class.
2003 Excellent Science Research Paper Awards of Ningbo, 1st Class.
2005 The Awards of Advancement in Science and Technology of Ningbo, 2nd Class.
2006 Education Awards of Zhejiang University.
2007 The Awards of Advancement in Science and Technology of Zhejiang Province, 3rd Class.
2007 Excellent Teacher Awards of Zhejiang University School of Medicine.
2009 Excellent Teacher Awards of Zhejiang University School of Medicine.
2009 Education Awards of Zhejiang University.
2011 Excellent Faculty Awards of Zhejiang University School of Medicine.
2012 Excellent Faculty Awards of Zhejiang University School of Medicine for education.
2013 Educational Achievement Zhejiang University, 2nd Class.
2013 Excellent Faculty Awards of Zhejiang University School of Basic Medical Sciences for education.

Funding:
1)Zhang X-N (PI): Systematically screening the personalized siRNA inhibitors and their effective transdermal delivery for epidermolytic palmoplantar keratoderma therapeutics. (2014)
Supported by The National Natural Science Foundation. Direct cost: RMB 100,000(~$16,000)
2)Zhang X-N (PI): Redoxome and Cancer, branch project. (2013-2017)
Supported by The National 973 Basic Research Program of China. Direct cost for 2013: RMB 100,000(~$16,000)
3)Zhang X-N (PI): Identify the disease-causing gene of Olmsted palmoplantar keratoderma by exome sequencing study. (2012)
Supported by The National Natural Science Foundation. Direct cost: RMB 100,000(~$16,000)
4)Zhang X-N (PI): Construct the mouse model of Krt9/indel in epidermolytic palmoplantar keratoderma by microinjection and gene knockin techniques. (2010-2013)
Supported by The National Natural Science Foundation. Direct cost: RMB 330,000(~$48,500).
5)Zhang X-N (PI): The preimplantation genetic diagnosis of epidermolysis palmoplantar keratoderma. (2007-2009)
Supported by The National Natural Science Foundation and The Foundation of Zhejiang University. Direct cost: RMB 610,000(~$78, 000).
6)Zhang X-N (PI): The prediagnostic platform of spinal muscular atrophy-1 (SMA1). (2007-2009)
Supported by The Foundation of S & T Department of Zhejiang Province. Direct cost: RMB 100,000(~$13,500).
7)Zhang X-N (PI): The mutation patterns of Chinese epidermolysis palmoplantar keratoderma. (2003-2005)
Supported by The Foundation of Public Health Deparment of Zhejiang Province and The Foundation of Ningbo S & T Committee. Direct cost: RMB 110,000(~$14,000).
8)Zhang X-N (PI): Researches on the modern techniques of molecular diagnosis. (2001-2003)
Supported by The Foundation of Ningbo S & T Committee. Direct cost: RMB 40,000(~$4,700).
9)Zhang X-N (PI): Mapping the schizophrenia susceptibility genes. (2000-2003).
Supported by The Zhejiang Provincal Natural Science Foundation, The Foundation of Education Deparment of Zhejiang Province, The Foundation of Public Health Deparment of Zhejiang Province and The Foundation of Ningbo S & T Committee. Direct cost: RMB 105,000(~$12,000).
10)Zhang X-N (PI): The role of arrestins in the desensitization of opioid receptor. (1996-1998).
Supported by China Postdoctoral Fellows Science Fund. Direct cost: RMB 10,000(~$1,000).

Teaching:
Lecturer and director of medical genetics course. The once lectured courses included Cell Biology, Medical Genetics, Immunology.

Main Research Publications: (*Correspondence author)
1)Wei W, He H-L, Chen C-Y, Zhao Y, Jiang H-L, Liu W-T, Du Z-F, Chen X-L, Shi S-Y, Zhang X-N*. Whole exome sequencing identifies PTCH1 and COL17A1 as susceptible genes in Chinese patients with ossification of the posterior longitudinal ligament of the cervical spine. Genetics and Molecular Research, 2014; 13(1):1794-1804.
2)Qi X-P, Liu W-T, Li J-Y, Dai Y, Ma J-M, Zhao Y, Fei J, Shen M, Jin H-Y, Chen Z-G, Du Z-F, Chen X-L, Zhang X-N*. p.N78S and p.R161Q germline mutations of the VHL gene are present in von Hippel-Lindau syndrome in two pedigrees. Molecular Medicine Reports, 2013; 8(3):799-805.
3)Qi X-P, Zhao J-Q, Du Z-F, Yang R-R, Ma J-M, Fei J, Cheng J, Han J-S, Jin H-Y, Chen Z-G, Wang J-Q, Yang Y-P, Ying R-B, Chen X-L, Liu W-T, Zhao Y, Jiang H-L, Zhang X-N*. Prophylactic thyroidectomy for MEN 2-related medullary thyroid carcinoma based on predictive testing for RET proto-oncogene mutation and basal serum calcitonin in China. European Journal of Surgical Oncology, 2013; 39(9):1007-1012.
4)Wei W, He H-L, Chen C-Y, Zhao Y, Jiang H-L, Liu W-T, Du Z-F, Chen X-L, Shi S-Y, Zhang X-N*. Whole exome sequencing identifies PTCH1 and COL17A1 as susceptible genes in Chinese patients with ossification of the posterior longitudinal ligament of the cervical spine. Genetics and Molecular Research, 2013; (in press).
5)Qi X-P, Du Z-F, Ma J-M, Chen X-L, Zhang Q, Fei J, Wei X-M, Chen D, Ke H-P, Liu X-Z, Li F, Chen Z-G, Su Z, Jin H-Y, Liu W-T, Zhao Y, Lan Z-Z, Li P-F, Fang M-Y, Dong W, Zhang X-N*. Genetic diagnosis of autosomal dominant polycystic kidney disease by targeted capture and next-generation sequencing: utility and limitations. Gene, 2013; 516(1):93-100.
6)Xu W-Z, Chen C-Y, Chen X-L, Zhao Y, Liu W-T, Du Z-F, Zhang X-N*. A novel de novo mutation of the NIPBL gene in an isolated Chinese patient with Cornelia de Lange syndrome. Chinese Medical Journal, 2013;126(1):191-192.
7)Qi X-P, Chen X-L, Ma J-M, Du Z-F, Fei J, Yang C-P, Cheng J, Song Q-Z, Han J-S, Jin H-Y, Chen Z-G, Wang J-Q, Yang Y-P, Ying R-B, Liu W-T, Chen X-L, Zhao Y, Chen C-Y, Jiang H-L, Ke H-P, Zhang X-N*. RET proto-oncogene genetic screening of families with multiple endocrine neoplasia type 2 optimizes diagnostic and clinical management in China. Thyroid, 2012; 22(12): 1257-1265.
8)Chen X-L, Zhao Y, Ke H-P, Liu W-T, Du Z-F, Zhang X-N*. Detection of somatic and germline mosaicism for the LAMP2 gene mutation c.808dupG in a Chinese family with Danon disease. Gene, 2012; 507(2):174-176.
9)Du Z-F, Xu C-M, Zhao Y, Liu W-T, Chen X-L, Chen C-Y, Fang H, Ke H-P, Zhang X-N*. Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita type 1 pedigrees associated with fissured tongue. European Journal of Dermatology, 2012; 22(4): 476-480.
10)Liu W-T, Ke H-P, Zhao Y, Chen X-L, Lu J-J, Du Z-F, Yu D, Zhang X-N*. The most common mutation of KRT9, c.C487T (p.R163W), in epidermolytic palmoplantar keratoderma in two large Chinese pedigrees. Anatomical Record, 2012; 295(4):604-609.
11)Shu L, Zhang Y-M, Huang X-X, Chen C-Y, Zhang X-N*. Complete mitochondrial DNA sequence analysis in two southern Chinese pedigrees with Leber hereditary optic neuropathy revealed secondary mutations along with the primary mutation. International Journal of Ophthalmology, 2012;5(1):28-31.
12)Qi X-P, Ying R-B, Ma J-M, Liu W-T, Du Z-F, Fei J, Yang C-P, Song Q-Z, Jin H-Y, Chen Z-G, Han J-S, Wang J-Q, Chen X-L, Zhao Y, Lu J-J, Zhang XN*. Case report: A p.C618S RET proto-oncogene germline mutation in a large Chinese pedigree with familial medullary thyroid carcinoma. Familial Cancer, 2012; 11(1):131-136.
13)Jiang JM, Chen X-L, Liu W-T, Guan YT, Han Y, Wang F, Lu J-J, Du Z-F, Yu ZL, Zhang XN*. Correlation between SEZ-6 gene variants and idiopathic generalized epilepsy in a southern Chinese Han population. Neural Regeneration Research, 2012;7(2):96-100.
14)Du Z-F, Wei W, Wang Y-F, Chen X-L, Chen C-Y, Lu J-J, Mao L-G, Xu C-M, Fang H, Zhang X-N*. A novel mutation within the 2B rod domain of keratin 9 in a Chinese pedigree with epidermolytic palmoplantar keratoderma combined with knuckle pads and camptodactyly. European Journal of Dermatology, 2011; 21(5):675-679. (An accompanying Editorial by European Journal of Dermatology, 2011; 21(5):659)
15)Wei W, Chen C-Y, Liu W-T, Du Z-F, Chen X-L, Zhang X-N*. Large deletions in the SMA region of a patient with type 3 spinal muscular atrophy. Neural Regeneration Research, 2011; 6(23):1810-1813.
16)Qi X-P, Ma J-M, Du Z-F, Ying R-B, Fei J, Jin H-Y, Han J-S, Wang J-Q, Chen X-L, Chen C-Y, Liu W-T, Lu J-J, Zhang J-G, Zhang X-N*. RET Germline Mutations Identified by Exome Sequencing in A Chinese Multiple Endocrine Neoplasia Type 2A/Familial Medullary Thyroid Carcinoma Family. PLoS One, 2011;6(5):e20353.
17)Jiang JM, Yu L, Guan YT, Yu ZL, Huang XH, Chen XS, Tang LS, Zhang XN. Seizure-related 6, a brain-specific expression gene, is highly expressed in the human cerebellum. Neural Regeneration Research, 2010;5(16):1231-1237.
18)Chen C-Y, Xu C-M, Du Z-F, Chen X-L, Ren G-L, Zhang XN*. A c.1363C>T (p.R455X) nonsense mutation of RB1 gene in a southern Chinese retinoblastoma pedigree. Genetic Testing and Molecular Biomarkers 2010;14(2): 193-196
19)Chen X-L, Xu C-M, Cai S-R, Chen C-Y, Zhang XN*. Prenatal diagnosis of epidermolytic palmoplantar keratoderma caused by c.T470C (p.M157T) of the keratin 9 gene in a Chinese kindred. Prenatal Diagnosis 2009;29(9):911-913
20)Xu C-M, Chen X-L, Chen C-Y, Zhang XN*. Missense mutation of keratin 9 (c.487C>T (p.R163W) in southern Chinese patients with epidermolytic palmoplantar keratoderma. European Journal of Dermatology 2009;19(3):265-266
21)Liang Y-H, Chen X-L, Yu Z-S, Chen C-Y, Bi S, Mao L-G, Zhou B-L, Zhang X-N*. Deletion analysis of SMN1 and NAIP genes in southern Chinese children with spinal muscular atrophy. Journal of Zhejiang University Science B, 2009;10(1):29-34.
22)Zhang X-N, Qi M. Mitochondrion and its related disorders: Making a comeback. Journal of Zhejiang University Science B,2008; 9(2):90-92
23)Zhang X-N, Zhou M-N, Qiu Y-Q, Ding S-P, Qi M, Li J-C. Genetic analysis of RET, EDNRB and EDN3 genes and three SNPs in MCS+9.7 in Chinese patients with isolated Hirschsprung disease. Biochemical Genetics,2007;45(7/8):523-527
24)Yu R, Zhang X-N*, Huang X-X, Ding S-P, Li J-C. Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: A case-control study. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics,2007;144B(4):570-573
25)Yu R, Lai Z, Zhou W, Ti D-D, Zhang X-N*. Recurrent FBN1 mutation (R62C) in a Chinese family with isolated ectopia lentis. American Journal of Ophthalmology,2006;141(6):1136-1138
26)Guo J-M, Xiao B-X, Kang G-Z, Liu D-H, Chen H, Zhang S, Zhang X-N. Suppression of telomerase activity and arrest at G1 phase in human cervical cancer HeLa cells by all-trans retinoic acid. International Journal of Gynecological Cancer, 2006;16 (1):341-346
27)Lai Z, Zhang X-N*, Zhou W, Yu R, Le Y-P. Evaluation of the ELOVL4 gene in a Chinese family with autosomal dominant STGD3-like macular dystrophy. Journal of Cellular and Molecular Medicine,2005; 9(4):961-965
28)Zhang X-N, He X-H, Li J-C. PCR products with heterozygous mutations containing two types of heteroduplexes. Journal of Zhejiang University(Medical Science),2005; 34(5):417-420(in Chinese)
29)Zhang X-N, He X-H, Lai Z, Mao W, He X-L, Li J-C. An insertion-deletion mutation in keratin 9 in three Chinese families with epidermolytic palmoplantar keratoderma. British Journal of Dermatology,2005; 152(4):804-806
30)He X-H, Zhang X-N*, Mao W, Chen H-P, Xu L-R, Chen H, He X-L, Le Y-P. A novel mutation of keratin 9 in a large Chinese family with epidermolysis palmoplantar keratoderma. British Journal of Dermatology,2004;150(4):647-651
31)Zhang X-N, Jiang S-D, He X-H, Zhang L-N. 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: Lack of association. American Journal of Medical Genetics,2004;126B(1):16-18
32)Zhang X-N, Ruan L-M, Le Y-P, Zhang Y. Association analysis between attention-deficit hyperactivity disorder (ADHD) and Val158Met polymorphism of catechol-O-methyltransferase gene (COMT). Chinese Journal of Medical Genetics,2003; 20(4):322-324(in Chinese)
33)Zhang X-N, Jiang S-D, Le Y-P, Qian Y-P, Wang D-X. Polymorphism of microsatellite markers D6S296, etc. in patients with schizophrenia. National Medical Journal of China, 2002;82(5):334-337(in Chinese)
34)Zhang X-N, Hu Z-H, Cao F-G, Zuo J. Research on the AZF deletion in patient with azoospermia and oligospermia. Reproduction and Contraception, 2002;22(6):342-345(in Chinese)
35)Dai FY, Yu L, He H, Zhao Y, Yang J, Zhang X-N, Zhao S-Y. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Genomics, 1999; 62(1):95 –97
36)Yang R, Lu S-D, Zheng Z-L, Zhao J, Zhang X-N, Chen L, Pei G, Ma L. Expression of opioid-receptor-like receptor(ORL1) gene in rat brain. Chinese Journal of Physiology, 1998; 50(2): 139-144(in Chinese)
37)Li X, Fan Y-X, Ji B-X, Zhang X-N, Zhu D-L, Geng Z-C. The association of different Human leucocyte antigen-DQ with myasthenia gravis. Chinese Medical Journal,1998; 111(9):802
38)Zhang X-N, Liu Y-G, Pazilaiti, Li D, Li X, Huang R-X, Li G-Q, Zhu D-L, Geng Z-C. Polymorphism of HLA-DQA1, -DQB1 genes in Uygur and Kazak ethnic groups and comprehensive analysis of 25 related populations. Acta Genetica, 1998; 25(3):193-198(in Chinese)
39)Zhang X-N, Pan X-H, Zhu D-L, Geng Z-C. HLA-DQB1 gene in Southern Han Chinese patients with systemic lupus erthymatosus. Chinese Journal of Immunology, 1997; 13(1):37-39(in Chinese)
40)Zhang X-N, Pazilaiti, Shao H-G, Zhu D-L, Geng Z-C. HLA-DQA1 and -DQB1 genotyping by PCR-RFLP in Xinjiang Han Chinese. Chinese Journal of Immunology, 1996,12(2):89-92(in Chinese)
41)Zhang X-N, Chen X-Z, Ji W, Zuo J, Cao F-G, Xia B-L, Li N-Z. Screening sibs in Wilson disease families by using Bayes theorem. Acta Academiae Medicinae Shanghai, 1995; 22(1):5-8(in Chinese)

Main Books:
1)Zhang X-N. Chapter 2 Elements of cell biology, Chapter 9 Gene mutation. In Du C-S (Editor-in-chief).Medical Genetics, 3rd ed. Beijing: People’s Medical Publishing House, 2014. (in Chinese)
2)Zhang X-N (Associate editor-in-chief). Medical Genetics, 6th ed. (Medical textbook for the national 5-year medical students) Beijing: People’s Medical Publishing House, 2013. (in Chinese)
3)Zhang X-N, Zuo J, Qi M (Editor-in-chief). Thompson and Thompson Genetics in Medicine (Bilingular edition). Beijing: Peking University Medical Press, 2009.
4)Fang H, Zhang X-N. Genetic counseling of inherited skin disorders. In Lu G, Xu X-M (Editor-in-chief). Clinical Genetic Counseling. Beijing: Peking University Medical Press,2007. (in Chinese)
5)Zhang X-N, Liu Y-Z, Huang C, He M-P (Editor-in-chief). Medical Genetics. Beijing: Science Press,2002. (in Chinese)
6)Liu W, Huang C, Zhang X-N (Editor-in-chief). A Study Guide to Medical Cell Biology and Medical Genetics. Shanghai: Fudan University Press,2002. (in Chinese)
7)Wang X-H, Liu W, Zhang X-N, Wang Z-H (Editor-in-chief). A Guide to Experiments of Medical Genetics. Beijing: Science Press,2001. (in Chinese)