Profile

Education Degrees: B.S., Sichuan University, China, 1993 Ph.D., Purdue University, 2005 M.S., BLEM, Chinese Academy of Sciences, 1996 Research Interest: Studying structure of biological complexes using Electron cryo-Microscopy (cryoEM) at high resolution to investigate their structures and mechanism, such as dsRNA virus, Herpesvirus, Bacteriophage and Vault. Developing strategies to acquire cryoEM images of biological complexes at atomic resolution. Developing algorithm of image processing to obtain cryoEM reconstructions of biological complexes at atomic resolution. Selected Publications: Zhang, X., Ding, K., Yu, X., Chang, W., Sun, J. & Zhou, Z.H. In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus. Nature 527, 531–534 (2015). Zhang, X.; Jin, L.; Fang, Q.; Hui, W.; Zhou, Z.H., 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry, Cell, 2010, 141 (3), 472-82. Zhang, X., Patel, A., Celma, C.C., Yu, X., Roy, P. & Zhou, Z.H. Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry. Nature structural & molecular biology 23, 74-80 (2016) Zhang X, Boyce M, Bhattacharya B, Zhang X, Schein S, Roy P, Zhou ZH, Bluetongue virus coat protein VP2 contains sialic acid-binding domains, and VP5 resembles enveloped virus fusion proteins, PNAS, 2010, 107 (14), 6292-7. Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff N, Near-atomic resolution using electron cryo-microscopy and single particle reconstruction, PNAS, 2008, 105 (6), 1867-72.