Profile

Curriculum Vitae
Name: Zhao Zhengyan
Gendle:: Male
Position: Party Secretary of Children’s Hospital  Zhejiang University School of Medicine

Specialization: Child Health Care
Research interest: Influence of genetic, environmental, psychological and social factors on children’s health

Contact address:              #57 Zhu Gan Lane, Hangzhou, P. R China 310003
E-mail: zhaozy@zju.edu.cn

Academic Appointment
January 1998 - present Professor of Pediatrics
Children’s Hospital Zhejiang University School of Medicine
2010—present,                    Qiushi Special-Term Professor, Zhejiang University

Professional experiences:
June 1984 – July 1990 Vice President of Children’s Hospital
Zhejiang University School of Medicine
September 1998 --June 2009     President of the Children’s Hospital
Zhejiang University School of Medicine
July 2003--present Head of the Institute for Pediatric Research, Zhejiang University
December 2004--present        Chief Editor of the World Journal of Pediatrics
June 2009– present           Party Secretary of Children’s Hospital
Zhejiang University School of Medicine

Visiting Scholar:
September 1989—November 1989   Visiting scholar, University of Uppsala, Sweden
May 1995—July 1995            Visiting scholar, Newfoundland St. John's Children's Health Center, Canada
May 1995—July 1995            Visiting scholar, Queen’s University, Canada

National Committees
October 2009—present      Chairman, Chinese Child Health Care Association (the 5th)
May 2007--present         Chairman, the Committee of Mental Retardation,  
                       Association for The Disabled, Zhejiang Province
November 2006--present    Vice Chairman, Pediatric Branch of Chinese Medical Association
September 2005--present    Vice Chairman, Pediatric Branch of Chinese Medical Doctor Association
September 2004--present    Chairman, Section in Newborn Screening of Chinese Child Health
Care Association
March 2001--present       Vice Chairman, the Medical Association of Preventive Medicine,
Zhejiang Province
September 2000--present    Chairman, the Zhejiang Pediatric Association Zhejiang Province
July 2000--present         Chairman, the Zhejiang Child Health Care Association
December 2001—present Vice Director of the Council of the Research Association for Trace
Elements and Health

Honors
1995   3rd grade Technology Advance Prize of the Zhejiang Provincial conferred by the Zhejiang Province People’s Government. Project: Survival in children 0 to 4 years of age in Zhejiang.
2000    3rd grade Technology Advance Prize of the Zhejiang Provincial Bureau of Technology conferred by the Zhejiang Province People’s Government. Project: Research on the relation between Vitamin A, transferritin receptor and iron metabolism.
2003    2nd grade Technology Advance Prize of the Zhejiang Provincial Bureau of Technology conferred by the Zhejiang Province People’s Government. Project: Epidemiology of cerebral palsy in infants – investigation and research on the causes.
2003   1st grade Zhejiang Provincial Technology Advance Prize in Pharmacology and Hygiene Innovation conferred by the Zhejiang Provincial Bureau of Public Health. Project: Epidemiology of cerebral palsy in infants – investigation and research on the causes.
2006 1st grade Zhejiang Provincial Technology Advance Prize in Pharmacology and Hygiene Innovation  conferred by the Zhejiang Provincial Committee of Technology. Project: Epidemiology of Lead Poisoning in infants – investigation and research on the causes.
2009 1st grade Zhejiang Provincial Science and Technology Prize. Project: Early Screening and          Investigation of Congenital Hypothyroidism and Phenylketonuria
2009 Soong Ching Ling Pediatrics Award. Project: Early Screening and Investigation of Congenital  Hypothyroidism and Phenylketonuria.
Research Projects
1. Monitor The Mortality of Children Under Five Years Old in Zhejiang Province
Zhejiang Provincial Bureau of Public Health
1994—1995
2. Research on Infant's Psychology Behavior
Queen’s University, Canada
1995-1997
3. Research on The Relation Between Vitamin A Deficiency, Anemia, Transferritin Receptor and Metabolism.
Zhejiang Provincial Bureau of Public Health
  1996—1998
4.  Epidemiology of Cerebral Palsy in Infants - Investigation and Research on The Causes.
Zhejiang Provincial Natural Science Foundation
1998—2000
5.  Clinical and Experimental Research on Lead Poisoning Effects of Preschoolers’ Immune System
  Zhejiang Provincial Medical and Health Care Project  
2000-2002
  6. Research on The Neurotoxin of Low-Level Lead Exposure on Newborn Mouse
Zhejiang Provincial Natural Science Foundation
2001-2003
 7. Study on The Effect of Lead Exposure on Children’s Intelligence
Zhejiang Provincial Family Planning Commission of Scientific Research Fund
     2001--2004
 8. Epidemiological Investigation of Lead Poisoning in Children and Clinical Research
Zhejiang Provincial Science and Technology Committee Research Project
   2002-2004
 9. Research on Mortality, Death Mode and Health Care Service Before Dying of Children Under Five Year Years Old in Zhejiang Province
   Zhejiang Provincial Statistics Bureau Research Project
   2002.5-2002.11
10. Screening for CH and PKU Patients and Investigation and Genetic Research on Patients’ Family Members
Zhejiang Provincial Committee of Scientific Technology
    2001--2005
 11. Research and Application of Prenatal Diagnosis of TORCH Syndrome and Down's Syndrome
    Zhejiang Provincial Bureau of Science and Technology
2001.12—2005.12
  12. Research on Community Rehabilitation of Children with Cerebral Palsy
     Zhejiang Provincial Administration of Traditional Chinese Medicine
2003.5~ 2005.4
13. Research on Screening For Children’s Fragile X Syndrome and Their Cognitive Phenotypes
     Zhejiang Provincial Natural Science Foundation
2005.1-2007.12
  14. Research on Williams Syndrome Children’s Cognitive Function and Neural Mechanism
    The Ministry of Health Science and Education Division
     2006.1-2008.12
15. Research on Screening For Children’s Fragile X Syndrome and Their Cognitive Phenotypes
     Zhejiang Provincial Family Planning Commission
     2006.1-2007.12
16. Effect on Early Iron Deficiency on Infant Brain Function and Behavior
National Natural Science Foundation
2007.1-2009.12
  17. Research and Application of Inborn Errors of Metabolism Tandem Mass Spectrometry Screening Kits
 Zhejiang Provincial Committee of Scientific Technology
 2006.7-2009.12
18. Research on Early Diagnosis and Intervention Therapy of Serious Dysfunction Disorders
 National Eleventh Five-Year Technology Support Program
 2008.01-2010.12
19. Establishment And Promotion of Congenital Heart Disease Prenatal Diagnosis Non-Invasive Screening Standardization Program
  National High Technology Research and Development Program (HTRDP)
  2007.06-2010.11
20. Akt / PTEN Regulation of Brain in The Development Period, "Nerve - Colloid - Vein" Micro-Environment and Correlation with Cognitive Disorder
   The Ph.D. Programs Foundation of Ministry of Education
2009.01-2011.12
   21. Effect of Iron Deficiency During Pregnancy on Infant Cognitive Development
  National Institutes of Health (NIH)
  2007.01-2011.12
22. Vascular Endothelial Cells PI3K/Akt Pathway in Regulation of Hippocampal Neuron Vein Unit Micro-Environment and Cognitive Dysfunction after Hypoxic-Ischemic Injury
       National Natural Science Foundation
       2010.1-2012.12
   23. Correlation Between Intrauterine Environment and Metabolic Syndrome and study of The Prevention and Control Technology
National Eleventh Five-Year Science Technology Support Program
       2009.12-2012.12
24. Study of Cognitive-brain Phenotyping of Atypical Chinese Children
       National Institutes of Health (NIH)
       2003.1-2007.12

Publications:
3. Shen Zheng, Zou Chaochun, Yang Rongwang, Zhao Zhengyan
Cleidocranial Dysplasia: Report of 3 Cases and Literature Review
CLINICAL PEDIATRICS  48(2):194-198 2009
                                                       IF:1.01
4. Zhan Jianying, Qin Yufeng, Zhao Zhengyan
Neonatal Screening for Congenital Hypothyroidism and Phenylketonuria in China
WORLD JOURNAL OF PEDIATRICS   5(2): 136-139 2009

3. Ni Shaoqing, Wang Xiumin, Wang Jue, Zeng Su, Zhao Zhengyan
Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4 Alpha In Large-For-Gestational-Age Neonatal Rats
PHARMAZIE   64(4):252-257 2009
IF: 0.858
4. Shen Diying, Wu Wei, Zhao Zhengyan
Mutations in Patients with Hyperphenylalaninemia in Zhejiang, China
GENES & GENOMICS    31(1): 85-88 2009

5. Zhang Li, Wu Lingling, Wang Yaping, Liu Aimin, Zou Chaochun, Zhao Zhengyan
Melamine-Contaminated Milk Products Induced Urinary Tract Calculi in Children
WORLD JOURNAL OF PEDIATRICS  5(1): 31-35 2009

6. Shi Shanshan, Shi Changchun, Zhao Zhengyan, Shen Hongqiang, Fang Xiangming, Tan Linhua, Zhang Xianghong, Shi Zhuo, Lin Ru, Shu Qiang
   Effect of Open Heart Surgery with Cardiopulmonary Bypass on Peripheral Blood Lymphocyte Apoptosis in Children
PEDIATRIC CARDIOLOGY    30 (2): 1583-159 2009
IF:1.03
7. Zou Chaochun, Liang Li, Wang Chunlin, Fu Junfen, Zhao Zhengyan
The Change in Ghrelin and Obestatin Levels in Obese Children After Weight Reduction
ACTA PAEDIATRICA     98(1): 159-165 2009
IF:1.517
8. Sun Li, Zhao Zhengyan, Zhou Xielai,Liu Suhang
The Effect of Lead on Intracellular Ca2+ in Mouse Lymphocytes
TOXICOLOGY IN VITRO   22(8): 1815-1819 2008
IF:2.473
9. Shi Shanshan, Zhao Zhengyan, Liu Xiwang, Shu Qiang, Tan Linhua, Lin Ru, Shi Zhuo, Fang Xiangming
Perioperative Risk Factors for Prolonged Mechanical Ventilation Following Cardiac Surgery in Neonates and Young Infants
CHEST    134(4): 768-774  2008
IF: 5.514
10. Zou Chaochun, Liang Li, Dong Guanping, Zhao Zhengyan
Peripheral Precocious Puberty: A Retrospective Study for Six Years in Hangzhou, China
JOURNAL OF PAEDIATRICS AND CHILD HEALTH  44(7-8): 415-418  2008
IF:1.124
11. Xie Chunhong, Yang Jianbin, Gong Fangqi, Zhao Zhengyan
Patent Ductus Arteriosus and Pulmonary Valve Stenosis in A Patient With 18p Deletion Syndrome
YONSEI MEDICAL JOURNAL  49(3): 500-502 2008
IF:0.784
12. Ji Chai, Huang Xinwen, Yang Rongwang, Wang Xu, Zhao Zhengyan
Gonadotropins and Sex Hormones in Healthy Chinese Infants
INDIAN PEDIATRICS   45(6): 489-492 2008
IF: 0.956
13. Zou Chaochun, Huang Ke, Liang Li, Zhao Zhengyan
Polymorphisms of The Ghrelin/Obestatin Gene and Ghrelin Levels in Chinese Children With Short Stature
CLINICAL ENDOCRINOLOGY     69(1): 99-104 2008
IF:3.398
14. Zou Chaochun, Liang Li, Zhao Zhengyan
Factors Associated With Fasting Plasma Ghrelin Levels in Children and Adolescents
WORLD JOURNAL OF GASTROENTEROLOGY    14(5):790-794 2008
IF:2.081
15. Huang Xinwen, Yin HM、Ji Chai, Qin Yufeng, Yang Rongwang, Zhao Zhengyan
Effects of Perinatal Hypothyroidism on Rat Behavior and its Relation With Apoptosis of Hippocampus Neurons
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION    31(1): 8-15 2008
IF:1.888
16. Li Hui, Li Yun, Shao Jie, Li Rong, Qin Yufeng, Xie Chunhong, Zhao Zhengyan
The Association Analysis of RELN and GRM8 Genes With Autistic Spectrum Disorder in Chinese Han Population
AMERICAN JOURNAL OF MEDICAL GENETICS   147B(2): 194-200 2008
IF:3.932
17. Wu Lingling, Zhang Li, Shao Jie, Zhao Zhengyan
Effect of Perinatal Iron Deficiency on Myelination and Associated Behaviors in Rat Pups
BEHAVIOURAL BRAIN RESEARCH  188(2): 263-270 2008
IF:3.171
18. Zou Chaochun, Liang Li, Hong Fang, Zhao Zhengyan
Glucose Metabolism Disorder in Obese Children Assessed by Continuous Glucose Monitoring System
WORLD JOURNAL OF PEDIATRICS  4(1): 26-30 2008

19. Yuan Zhefeng, Mao Huaqing, Luo Yanfei, Wu Yidong, Shen Zheng, Zhao Zhengyan
Thyrotropin Receptor and Thyroid Transcription Factor-1 Genes Variant in Chinese Children With Congenital Hypothyroidism
ENDOCRINE JOURNAL   55(2):415-423 2008
IF: 1.6
20. Wang Yanxia, Mao Shanshan, Xie Chunhong, Qin Yufeng, Zhu Zhiwei, Zhan Jianying, Shao Jie, Li Rong, Zhao Zhengyan
Study on The Social Adaptation of Chinese Children With Down Syndrome
YONSEI MEDICAL JOURNAL   48(3): 412-420 2007
IF: 0.784
21. Xie Chunhong, Xia Chengseng, Zhao Zhengyan, Zhou Yinbao
Hemodynamic Features of Congenital Aortic Valve Stenosis With Patent Ductus Arteriosus in Children
PEDIATRICS INTERNATIONAL   49(6): 908-910 2007
IF: 0.677
  22. Yang Rongwang, Li Rong, Mao Shujiong, Sun Liying, Huang Xinwen, Ji Chai, Zhu Zhiwei, Wu Lingling, Qin Yufeng, Zhao Zhengyan
The Survey of Serum Retinol of The Children Aged 0-4 Years in Zhejiang Province, China
BMC PUBLIC HEALTH      25 (7): 264-271
                                                       IF: 2.029
23. Mao Shanshan, Wang Yanxia, Jiang Guoping, Zhao Zhengyan
Effects of Levothyroxine Therapy on Left And Right Ventricular Function in Neonates With Congenital Hypothyroidism: A Tissue Doppler Echocardiography Study.
EUROPEAN JOURNAL OF PEDIATRICS   166(12): 1261-1265 2007
                                                        IF: 1.416
24. Zou Chaochun, Zhao Zhengyan
Clinical and Molecular Analysis of NF-Kappa B Essential Modulator in Chinese Incontinentia Pigmenti Patients.
INTERNATIONAL JOURNAL OF DERMATOLOGY   46(10): 1017-1022 2007
                                                        IF: 1.409
25.Xie Chunhong, Zhao Zhengyan, Zhou Yinbao, Gong Fangqi
Single Coronary Artery With Fistula, Right Aortic Arch, Bicuspid Aortic Valve, and Pulmonary Stenosis: A Rare Combination
PEDIATRIC CARDIOLOGY     28(4): 286-288 2007
                                                         IF: 1.03
26. The Association Analysis of RELN and GRM8 Genes With Autistic Spectrum in Chinese Han Population.
AMERICAN JOURUAL OF MEDICAL GENETICS PART B(Neuropsychiatric Genetics)
9999:1-7(2007)

27.  Lou Jin-gan,Chen Jie,Huang Xiao-lei,Zhao Zheng-yan
Changes in The Intestinal Microflora of Children With Helicobacter Pylori Infection and After Helicobacter Pylori Eradication Therapy
CHINESE MEDICAL JOURNAL       20 (10): 929-931 MAY 20 2007
Times Cited: 0                                                                    IF:0.858

28. Fu, J-F, Liang, L,Zou, C-C,Hong, F, Wang, C-L,Wang, X-M, Zhao ZY
Prevalence of The Metabolic Syndrome in Zhejiang Chinese Obese Children and Adolescents and The Effect of Metformin Combined With Lifestyle Intervention
INTERNATIONAL JOURNAL OF OBESITY    31 (1): 15-22 JAN 2007
Times Cited: 2                                                                    IF:4.055

29、Zou CC, Zhao ZY, Tang LF, Liang L
Plasma Levels of Matrix Metalloproteinase-9 in Henoch-Schonlein Purpura
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY    35 (1): 52-55 FEB 2006
Times Cited: 1                                                                    IF:2.273

30、Zou CC, Liang L, Hong F, Fu JF, Zhao ZY
Serum Adiponectin, Resistin Levels and Non-Alcoholic Fatty Liver Disease in Obese Children
ENDOCRINE JOURNAL    52 (5): 519-524 OCT 2005
Times Cited: 8                                                                    IF:1.140

31、Sun L, Zhao ZY, Li R, Cheng HY
Decrease of CD4(+) T-lymphocytes in Children Exposed to Environmental Lead
BIOLOGICAL TRACE ELEMENT RESEARCH    105 (1-3): 19-25 SUM 2005
Times Cited: 0                                                                    IF:1.007

32、Shang SQ, Chen GX, Wu YD, Du LZ, Zhao ZY
Rapid Diagnosis of Bacterial Sepsis With PCR Amplification and Microarray Hybridization in 16S Rrna Gene
PEDIATRIC RESEARCH    58 (1): 143-148 JUL 2005
Times Cited: 4                                                                    IF:2.619

33、Sun L, Zhao ZY, Li L, Cheng HY
Preschool Children's Lead Levels in Rural Communities of Zhejiang Province, China
NTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 207 (5): 437-440 OCT 2004
Times Cited: 0                                                                    IF:1.733

34、Li R, Zhao ZY
Two Subtelomeric Chromosomal Deletions in Forty-Six Children With Idiopathic Mental Retardation
CHINESE MEDICAL JOURNAL    117 (9): 1414-1417 SEP 2004
Times Cited: 2                                                                   IF:0.615

35、Jiang KW, Zhao ZY, Shui QX, Xia ZZ
Electro-Acupuncture Preconditioning Abrogates The Elevation of C-Fos and C-Jun Expression in Neonatal Hypoxic-Ischemic Rat Brains Induced by Glibenclamide, An ATP-Sensitive Potassium Channel Blocker
BRAIN RESEARCH    998 (1): 13-19 FEB 13 2004
Times Cited: 5                                                                   IF:2.341

36、Li L, Shui QX, Zhao ZY
Regulation of Brain-Derived Neurotrophic Factor (BDNF) Expression Following Antibiotic Treatment of Experimental Bacterial Meningitis
JOURNAL OF CHILD NEUROLOGY    18 (12): 828-834 DEC 2003
Times Cited: 5                                                                   IF:1.350

37、Zou CC, Zhao ZY, Tang LF, Chen ZM, Du LZ
The Effect of Lead on Brainstem Auditory Evoked Potentials in Children
CHINESE MEDICAL JOURNAL    116 (4): 565-568 APR 2003
Times Cited: 1                                                                 IF:0.615

38、Sun L, Hu J, Zhao ZY, Li L, Chen HY
Influence of Exposure to Environmental Lead on Serum Immunoglobulin in Preschool Children
ENVIRONMENTAL RESEARCH    92 (2): 124-128 JUN 2003
Times Cited: 4                                                                 IF:2.556

39、Sun L, Zhao ZY, Hu R, Zhou XL
Potential Association of Lead Exposure During Early Development of Mice With Alteration of Hippocampus Nitric Oxide Levels and Learning Memory
BIOMEDICAL AND ENVIRONMENTAL SCIENCES  18 (6): 375-378 DEC 2005
Times Cited: 0                                                                 IF:0.748

40、Cornish K, Zhao ZY, Fu G, Jie S, Hammond P, Mill D, Tassabehji M, Karmiloff-Smith A
Cognitive-Brain Phenotyping in Chinese Children With Genetic Disorders    
Meeting Abstract
JOURNAL OF COGNITIVE NEUROSCIENCE :    60-60 Suppl. S 2005
Times Cited:0  IF:5.197