Researchers Reveal the Secrete of Nonrandom DNA Seg-regation in Human Cells

2014-03-03   |  
Schizophrenia is one kind of severe neuropsychiatric diseases which affect almost 1% of the world population. But the pathological mechanisms are still unclear. Recent years ErbB4 as one of the risk genes of schizophrenia had been paid much attention. Dr. Li’s lab used genetic tools to deleted ErbB4 receptors in GABAergic forebrain neurons during the early development period and demonstrated that in the mouse mPFC, ErbB4 signals were dispensable for the development of GABAergic synapses by parvalbumin (PV) Fast-spiking (FS) basket cells. Interestingly, they were required for the final maturation rather than the initial formation of glutamatergic synapses on PV FS basket cells. Furthermore, activity-dependent GABAergic PV FS pyramidal neuron transmission was decreased, whereas activity of pyramidal neurons was increased in KO mice. This disruption of excitatory-inhibitory balance may happen to the pathology of schizophrenia. Their founding has been published on neuroscience top journal Journal of Neuroscience.