PATHOPHYSIOLOGY

Course Number: 18122550

Prerequisites: Human anatomy, Physiology, Biochemistry, Cellular and molecular biology
Credits: 2.5 credits
Activities: Lectures and Tutorials (32 units); Lab performance (16 units), Outside reading
Year: 2st year 2 ^nd semester

 

COURSE DESCRIPTION:

Pathophysiology is a science concerning the etiology and pathogenesis of diseases, as well as the mechanisms of functional and metabolic alterations in diseases. It provides a link between the sciences of anatomy, physiology, biochemistry and its application to clinical practice. Emphasis is placed on the mechanisms and concepts of most commonly encountered diseases and disorders to the human body. Selected elements include fever, hypoxia, stress, shock, disturbances of hemostasis, abnormal cell proliferation and differentiation, heart failure, etc. These may provide awareness of possible implications of certain aspects of diseases, current scientific advances and selected therapeutics. The course aims to enable students to apply scientific reasoning skills to the study of diseases.

 

OBJECTIVES:

The objectives of this course are to enable students to possess a well-grounded understanding of normal physiologic and pathologic mechanisms of diseases. And we also try to let the clinical students relate this knowledge to interpreting changes in normal function that result in symptoms indicative of illness. Students will have the opportunity to apply knowledge of pathophysiology in conjunction with information regarding medical history and laboratory data to solve case based clinical problems during small group discussion. Upon satisfactory completion of this course, the student will be able to:

1.Understand the basic mechanisms by which disease occurs and the responses of the body to these disease processes.

2.Analyze various ways in which innate adaptive and compensatory physiological mechanisms are affected by specific pathological conditions.

3.Analyze the relationship between normal physiologic and pathological phenomena produced by altered states

4.correlate alterations in the physiological function of the body to clinical presentation of signs and symptoms. 

5.Develop clinical inferences based on knowledge of disordered functioning in the human. 

6.Communicate knowledge of course content clearly and accurately.

7.Develop personal skills in the use of technology in the educational processes.

 

COURSE CONTENT:

Lectures (32 hr)

Conspectus of Disease   2 hr                                   

1.Concept of disease

2.Etiology of disease

3.Pathogenesis of disease

4.Outcome of disease

Fever   2 hr                                             

1.Etiology

2.Pathogenisis

3.Stages of manifestations

4.Alterations of metabolism and function

5.Pathophysiological basis of prevention and treatment

Hypoxia   2 hr                                                 

1.Parameters of blood oxygen

2.Classification, Etiology and Mechanisms of Hypoxia

3. Alterations of metabolism and function in the body

4.Pathophysiological basis of prevention and treatment

Water and Electrolytes Balance and Imbalance   5 hr                   

1.Water and sodium balance and imbalance

2.Disorders of sodium and water metabolism

3.Disorders of Potassium metabolism

Acid-Base Balance and Imbalance   5 hr                            

1.Normal acid-base balance

2.Parameters of acid-base balance

3.Simple acid-base balance

4.Mixed acid-base balance

Signal transduction and the Related Disorders   2 hr                   

1.General concept

2.Major pathways for cell signaling

3.Dysfunction of cell signaling in disease

4.Pathophysiological basis of prevention and treatment of disease

Stress and Related Disease    2 hr                                 

1.Etiology and pathogenesis

2.Alterations of metabolism and function

3.Stress and disease

4.Basic principle of prevention and treatment for stress disorders

Shock   2 hr                                                   

1.Etiology and classification of shock

2.Pathogenesis of shock

3.Alterations of metabolism and function

4.Features of several common types of shock

5.Pathophysiological basis of prevention and treatment

Disseminated intravascular coagulation (DIC)    2 hr                               

1.Etiology

2.Pathology

3.Pathogenesis

4.Factors influence the development of DIC

5.Clinical classification of DIC

6.Alterations of metabolism and function

7.Pathophysiological basis of prevention and treatment

Heart Failure   2 hr                                           

1.Fundamental knowledge

2.Etiology and Classification

4.Compensatory responses

5.Pathogenesis

6.Clinical manifestation

7.Pathophysiological basis of prevention and treatment

Respiratory Failure   2 hr                                     

1.Etiology and Classification

2.Pathogenesis

3.Alterations of metabolism and function

4.Pathophysiological basis of prevention and treatment

Renal Failure   2 hr                                           

1.Acute renal failure

2.Chronic renal failure

3.Uremia

Tutorial   2 hr                                                

 

Practices (16 hr)

1.Basic train for operation   4 hr   

2.Hypoxia   4 hr 

3.Acute lung edema   4 hr

4.Case Discussion   4 hr  

 

STRUCTURE:

The course comprises 32 hr of lectures and 16 hr of practices.

Two lecture sessions, one for 2 hr and one for 3 hr, will be held each week.

One weekly 4 hr practical session will be held.

Two tests (1 hr each) will be given before the final examination, at about the sixth (multiple-choice and short-answer questions) and twelfth weeks (essay questions).

The final examination (2 hr) will contain a mixture of the above types of questions.

 

ORGANIZATION:

Each session will be offered to the entire class.

An assistant will act as liaison between students and teachers, and will be responsible for taking attendance, collecting exam papers, and related matters.

 

EVALUATION:

Students’ performance will be evaluated on the basis of attendance at lectures and participation in practices (5%), practical reports (15%), scores on tests (20%), and scores on the final examination (60%).

RECOMMENDED TEXTBOOK:

Pathophysiology. Wang Jianzhi, Jin Huiming. Firth Edition. People’s Medical Publishing House 2005. ISBN: 7-117-06656-3

 

SUPPLEMENTARY READING:

Essentials of Pathophysiology: Concepts of altered Health States. Carol Mattson Porth. Second edition. Lippincott Williams & Wilkins. 2005. ISBN:0-7817-7087-4

 

TEACHING TEAM:

 

Faculty:

Prof. Shao Jimin

Tel: 88208209

Email: shaojimin@zju.edu.cn

Rm 339, Block C, Research Building, School of Medicine, Zijingang Campus

 

Dr. Hu Hu

Tel: 88208209

Email: huhu@ zju.edu.cn

Rm 303, Block B, Research Building, School of Medicine, Zijingang Campus

 

Dr. Jin Jinghua

Tel: 88208247

Email: huxiaolan1998@yahoo.com.cn

Rm 516, Block B, Research Building, School of Medicine, Zijingang Campus

 

Dr. Hu Xiaolan

Tel: 88208208

Email: huxiaolan1998@yahoo.com.cn

Rm 337, Block C, Research Building, School of Medicine, Zijingang Campus

 

Assistant:

Dr. Hu Xiaolan

Tel: 88208208

Email: huxiaolan1998@yahoo.com.cn

Rm 337, Block C, Research Building, School of Medicine, Zijingang Campus