Profile

Education:
09/2002-06/2007 Ph.D, Zhejiang University School of Medicine
Speciality: Occupational Health and Environmental Health


09/1997-07/2002 B.M., Zhejiang University School of Medicine
Speciality: Preventive Medicine

Research Experience:
03/2011-Present
1. Investigation of the cellular DNA damage response to environmental EMF exposure.
2. Investigation of the role of the tumor suppressor Tip60 in gastric cancer metastasis.
12/2007- 03/2011 (As a Post-doc Research Fellow, University of British Columbia)
1. Identification of the tumor suppressor ING3 degradation pathway. ING3 is degradated by SCFSkp2-mediated ubiquitin-proteasome system and interruption of ING3 degradationg enhances the tumor-suppressive function of ING3 (Oncogene 29: 1498).
2. Elucidating the role of Cul1 (scaffold protein in SCF complex) in melanoma initiation and development. Cul1 expression is increased in early stages of human melanoma, and Cul1 regulates melanoma cell growth and cell cycle progression through degradation of p27 by functional SCFSkp2 complex (Pigment Cell Melanoma Res 23: 572, Int J Oncol 37: 1339).
3. Evaluating the prognositic values of the tumor biomarkers (Skp2, p27 and Tip60) in human melanomas. 1）Skp2 is over-expressed in cytoplasm of human melanoma and the increased cytoplasmic Skp2 expression is associated with poor primary melanoma patient survival (Plos One 6: e17578); 2) Nuclear p27 expression is reduced in malignant melanomas, which is correlated with the increased p27 level in cytoplasm. Both loss of nuclear p27 expression and gain of cytoplasmic p27 expression are correlated with a worse survival of melanoma patients (Cancer Epidemiol Biomarkers Prev Under review); 3) Tip60 expression is reduced in metastatic melanoma and reduced Tip60 expression is an independent prognostic marker for metastatic melanomas (Am J Pathol Under review).

09/2002-11/2007 (As a Ph.D student, Zhejiang University School of Medicine)
1. Investigation of mobile phone radiation induced bio-effects. By transcriptomic (Genechip assay and quantitative real-time RT-PCR) and proteomic (two dimension gel electrophoresis and mass spectrum) approaches, GSM 1800 MHz Radiofrequency EMF exposure can not change gene and protein expression in MCF-7 cells (Proteomics 6: 4732)
2. Investigation of electromagnetic fields (EMF) induced global gene expression in Saccharomyces Cerevisiae. The effect of EMF on gene expression in depends on the frequency of EMF (Bioelectromagnetics Under review).

09/2001-06/2002 (As an undergraduate student, Zhejiang University School of Medicine)
Study on the antioxidant ability of commercial health-care foods by total oxyradical scavenging capacity (TOSC) assay (Zhejiang Journal of Preventive Medicine, 16: 26).

Honors:
2008-2011, Awarded the MSFHR Post-doctoral Research Fellowship.
2007, Awarded 2007 sessions of outstanding post-graduates of Zhejiang University.
2005~2006, Awarded the first-class scholarship and the third class prize in the Nan-Du scholarship, and titled the excellent student of Zhejiang university.
2004~2005, Awarded the Wang-TiWu scholarship.
2000~2001, Awarded the outstanding student leader of Zhejiang university.

Publications:
2016
1. Jing Guo, Yue Fei, Junqin Li, Lisan Zhang, Qiong Luo, Guangdi Chen*. Duration and Prevalent Hypertension among Middle-aged and Elderly Chinese Adults, A Cross-sectional Study from CHARLS 2011-2012. BMJ Open 2016 In press.
2. Jing Guo, Liling Su, Xinyuan Zhao, Zhengping Xu, Guangdi Chen*. Relationships between urinary antimony levels and both mortalities and prevalence of cancers and heart diseases in general US population, NHANES 1999-2010. Sci Total Environ. 2016 Jul 8. [Epub ahead of print] (*Co-corresponding Authors) PMID: 27396316
3. Liling Su, Yue Fei, Xiaoxia Wei, Jing Guo, Xiangen Jiang*, Liqin Lu*, Guangdi Chen*. Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk. Leuk Lymphoma. 2016 Apr 7: 1-8. [Epub ahead of print] (*Co-corresponding Authors) PMID: 27054704
4. Dongyu Li, Xinyuan Zhao, Wei Qin, Hequn Zhang, Yue Fei, Liwei Liu, Ken-Tye Yong, Guangdi Chen*, Ben Zhong Tang*, Jun Qian*. Toxicity assessment and long-term three-photonfluorescence imaging of bright aggregation-inducedemission nanodots in zebrafish. Nano Research 2016, 9(7): 1921-1933. (*Co-corresponding Authors)
5. Li Jiang, Xinyuan Zhao, Yue Fei, Dongdong Yu, Jun Qian, Jinguang Tong, Guangdi Chen*, Sailing He*. The effects of magnetic fields exposure on relative permittivity of saline solutions measured by a high resolution SPR system.Sci Rep. 2016 Apr 28; 6: 25111. (*Co-corresponding Authors) PMID: 27121618
6. Zhaopin Wang, Lijuan Wang, Shuangshuang Zheng,Zheyuan Ding, Hui Liu, Wen Jin, Yifeng Pan, Zexin Chen, Ying Fei, Guangdi Chen, Zhengping Xu, Yunxian Yu*. Effects of electromagnetic fields on serum lipids in workers of a power plant. Environ Sci Pollut Res Int. 2016 Feb; 23(3): 2495-504. PMID: 26423285
7. Chen Lin, Xinyuan Zhao, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu*, Xiangwei Gao*. Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress. Sci Rep. 2016 Feb 16; 6: 21133. (*Co-corresponding Authors) PMID: 26878911
8. Zhaopin Wang, Ying Fei, Hui Liu, Shuangshuang Zheng, Zheyuan Ding, Wen Jin, Yifeng Pan, Zexin Chen, Lijuan Wang, Guangdi Chen, Zhengping Xu, Yongjian Zhu, Yunxian Yu*. Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant. Int Arch Occup Environ Health. 2016 Jan; 89(1):33-42. PMID: 25808749

2015
9. Rongpan Bai, Chunhua Weng, Haojie Dong, Siqi Li, Guangdi Chen*, Zhengping Xu*. MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression. Int J Cancer. 2015 Nov 15; 137(10): 2310-22. (*Co-corresponding Authors) PMID: 25991585
10. Wen Sun, Liling Su, Yan Sheng, Ye Shen*, Guangdi Chen*. Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis? BMC Ophthalmology. 2015 Jul 26; 15: 84. (*Co-corresponding Authors) PMID: 26208492
11. Guohong Zhang, Yabin Cheng, Guangdi Chen, Yun Tang, Gholamreza Ardekani, Anand Rotte, Magdalena Martinka, Kevin McElwee, Xuezhu Xu, Qi Wang*, Youwen Zhou*. Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor prognosis. Oncotarget. 2015 Sep 8; 6(26): 23026-35. (*Co-corresponding Authors) PMID: 26246476
12. Jun Qian, Zhenfeng Zhu, Chris Wai Tung Leung, Wang Xi, Liling Su, Guangdi Chen, Anjun Qin, Ben Zhong Tang*, Sailing He*. Long-term two-photon neuroimaging with a photostable AIE luminogen. Biomed Opt Express. 2015 Mar 24; 6(4):1477-86. (*Co-corresponding Authors) PMID: 25909029
13. Yongdui Chen, Siqi Li, Liling Su, Jinghao Sheng, Wen Lv, Guangdi Chen*, Zhengping Xu*. Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis. J Neurol. 2015 Apr;262(4):814-22. (*Co-corresponding Authors) PMID: 25578179
14. Yabin Cheng, Jing Lu, Guangdi Chen, Gholamreza Safaee Ardekani, Anand Rotte, Magdalena Martinka, Xuezhu Xu, Kevin J. McElwee, Guohong Zhang*, Youwen Zhou*. Stage-specific prognostic biomarkers in melanoma. Oncotarget. 2015 Feb 28;6(6):4180-9. (*Co-corresponding Authors) PMID: 25784655
15. Kanghui Li, Xinyuan Zhao, Yixing Zhai, Guangdi Chen, El-Hang Lee, Sailing He*. A Study on the Biocompatibility of Surface-Modified Au/Ag Alloyed Nanobox Particles in Zebrafish in Terms of Mortality Rate, Hatch Rate and Imaging of Particle Distribution Behavior. Progress In Electromagnetics Research. 2015, 150, 89-96.

2014
16. Hui Liu, Guangdi Chen, Yifeng Pan, Zexin Chen, Wen Jin, Chuan Sun, Chunjing Chen, Xuanjun Dong, Kun Chen, Zhengping Xu, Shanchun Zhang, Yunxian Yu*. Occupational Electromagnetic Field Exposures Associated with Sleep Quality: A Cross-Sectional Study. PLoS One. 2014; 9(10): e110825. PMID: 25340654
17. Rongpan Bai, Yu Weng, Lilin Su, Mingjuan Jin, Zhengping Xu, Liqin Lu*, Guangdi Chen*. Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis. Asian Pac J Cancer Prev. 2014;15(23):10107-14. (*Co-corresponding Authors) PMID: 25556434
18. Wen Sun, Yan Sheng, Yu Weng, Chunxiao Xu, Susan EI Williams, Yutao Liu, Michael A Hauser, R. Rand Allingham, Mingjuan Jin, Guangdi Chen*. Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis. Int J Ophthalmol. 2014, 7(3): 550-556. PMID: 24967207
19. Jinghao Sheng, Liling Su, Zhengping Xu, Guangdi Chen*. Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease. Gene. 2014, 542(2):141-5. PMID: 24680777
20. Yingjun Li, Yingying Mao, Yang Zhang, Shaofang Cai, Guangdi Chen, Ye Ding, Jing Guo, Kun Chen, MingJuan Jin*. Alcohol drinking and upper aerodigestive tract cancer mortality: A systematic review and meta-analysis. Oral Oncol. 2014, 50(4): 269-75. PMID: 24405883

2013
21. Meibian Zhang, Xinglin Fang, Lifang Zhou, Liling Su, Jiajia Zheng,Minjuan Jin, Hua Zou*, Guangdi Chen*. Pesticide poisoning in Zhejiang, China: a retrospective analysis of adult cases registration by occupational disease surveillance and reporting systems from 2006 to 2010. BMJ Open 2013; 3: e003510. (*Co-corresponding Authors) PMID: 24270833
22. Zhenfeng Zhu, Xinyuan Zhao, Wei Qin, Guangdi Chen, Jun Qian, Zhengping Xu. Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging. Science China Chemistry. 2013, Sep; 56 (9): 1247-1252
23. Yabin Cheng, Guangdi Chen, Magdalena Martinka, Vincent Ho and Gang Li*. Prognostic Significance of Fbw7 in Human Melanoma and its Role in Cell Migration. J Invest Dermatol. 2013 Jun; 133 (7):1794-802. PMID: 23381582
24. Shanshan Xu, Guangdi Chen, Chunjing Chen, Chuan Sun, Dandan Zhang, Manuel Murbach, Niels Kuster, Qunli Zeng*, Zhengping Xu*. Cell Type-Dependent Induction of DNA Damage by 1800 MHz Radiofrequency Electromagnetic Fields Does Not Result in Significant Cellular Dysfunctions. PLoS One. 2013; 8 (1): e54906. (*Co-corresponding Authors). PMID: 23355902
25. Yibo Yu, Yu Weng, Jing Guo, Guangdi Chen*, Ke Yao*. Association of Glutathione S transferases Polymorphisms with Glaucoma: A Meta-Analysis. PLoS One. 2013; 8 (1): e54037. (*Co-corresponding Authors). PMID: 23342067

2012
26. Hongjie Zhou, Guangdi Chen, Chunjing Chen, Yunxian Yu*,Zhengping Xu*. Association between Extremely Low-frequency Electromagnetic Fields Occupations and Amyotrophic Lateral Sclerosis: A Meta-analysis. PLoS One. 2012, 7 (11): e48354. (*Co-corresponding Authors). PMID: 23189129.
27. Guangdi Chen, Yabin Cheng, Yun Tang, Magda Martinka, Gang Li*. Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival. J Invest Dermatol. 2012 Nov; 132 (11): 2632-2641. PMID: 22673729
28. Guangdi Chen, Deqiang Lu, Huai Chiang, Dariusz Leszczynski D, Zhengping Xu*. Using model organism Saccharomyces cerevisiae to evaluate the effects of ELF-MF and RF-EMF exposure on global gene expression. Bioelectromagnetics. 2012 Oct; 33 (7): 550-560. PMID: 22487891.
29. Chunhua Weng, Haojie Dong, Guangdi Chen, Yixing Zhai, Rongpan Bai, Hu Hu, Linrong Lu, Zhengping Xu*. miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin. Cancer Lett. 2012 Oct; 323 (2): 171-179. PMID: 22531314
30. Yu Weng, Liqin Lu, Guorong Yuan, Jing Guo, Zhizhong Zhang, Xinyou Xie, Guangdi Chen*, Jun Zhang*. p53 codon 72 polymorphism and Hematological Cancer Risk: An Update Meta-Analysis. PLoS One. 2012 Sep; 7 (9): e45820. (*Co-corresponding Authors). PMID: 23029260.
31. Gang Wang*, Lingyan Zheng, Zhijian Yu, Guodong Liao, Liqin Lu, Rujun Xu, Zhongsheng Zhao, Guangdi Chen*. Increased cyclin-dependent kinase 6 expression in bladder cancer. Oncology Letters. 2012 Jul; 4 (1): 43-46. (*Co-corresponding Authors). PMID: 22807957.
32. Yu Weng, Jun Zhang, Xue Tang, Xinyou Xie*, Guangdi Chen*. Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. Leuk Lymphoma. 2012 Jul; 53 (7): 1345-1351. PMID: 22166040 (*Co-corresponding Authors)

2011
33. Guangdi Chen, Yabin Cheng, Zhizhong Zhang, Magdalena Martinka, Gang Li*. Prognostic significance of cytoplasmic p27 expression in human melanoma. Cancer Epidemiol Biomarkers Prev. 2011 Oct; 20(10): 2212-2221. PMID: 21828232
34. Zhizhong Zhang, Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Prognostic Significance of RUNX3 Expression in Human Melanoma. Cancer. 2011 Jun; 117 (12): 2719-2727. PMID: 21656750
35. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cytoplasmic Skp2 Expression Is Increased in Human Melanoma and Correlated with Patient Survival. Plos One. 2011 Feb; 6(2):e17578. PMID:21386910

2010
36. Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li*. Cul1 expression is increased in early stages of human melanoma. Pigment Cell Melanoma Res. 2010 Aug; 23 (4): 572-574. PMID: 20518860
37. Guangdi Chen, Gang Li*. Increased Cul1 expression promotes melanoma cell proliferation through regulating p27 expression. Int J Oncol. 2010 Nov; 37(5):1339-1344. PMID: 20878082
38. Jin Bai, Yan Zhou, Guangdi Chen, JinyanZeng, Jingjing Ding, Yongfei Tan, Jianwei Zhou*, Gang Li*. Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. Human Pathology. 2010 Mar; 42(3): 375-383 PMID: 21190721
39. Guangdi Chen#, Yemin Wang#, Marco Garate, Jianwei Zhou, Gang Li*. The tumor suppressor ING3 is degraded by SCF (Skp2)-mediated ubiquitin-proteasome system. Oncogene. 2010 Mar; 29(10):1498-1508. (# Co-first authors) PMID: 19935701

2006-2009
40. Yibo Yu, Ke Yao*, Wei Wu, K Wang, Guangdi Chen, Deqiang Lu. Effects of exposure to 1.8 GHz radiofrequency field on the expression of Hsps and phosphorylation of MAPKs in human lens epithelial cells. Cell Res. 2008 Dec; 18(12):1233-1235. PMID: 19015670
41. Xiaoming Xing, Maode Lai*, Wolfgang Gartner, EnpingXu, Qiong Huang, Han Li, Guangdi Chen. Identification of differentially expressed proteins in colorectal cancer by proteomics: Down-regulation of secretagogin. Proteomics 2006 Jun; 6 (9): 2916-2923. PMID: 16586428.
42. Qunli Zeng#, Guangdi Chen#, Yu Weng, Lingli Wang, Huai Chiang, Deqiang Lu, ZhengpingXu*. Effects of Global System for Mobile Communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells. Proteomics 2006 Sep; 6 (17): 4732-4738. PMID: 16888767 (# Co-first authors)

中文文章
43. 魏晓霞, 许正平, 陈光弟. 移动电话射频电磁场暴露促动物肿瘤发展作用的研究进展. 中华劳动卫生职业病. 2016, 34(2): 155-158.
44. 赵新元, 方文攀，林晨，陈光弟. 极低频电磁场暴露与不良妊娠结局风险关联研究进展. 高电压技术. 2015, 41(4): 1383-1389.
45. 苏丽玲, 金明娟, 许正平, 陈光弟. 职业性极低频电磁场暴露与神经退行性疾病发病关联的研究进展. 中华流行病学杂志. 2014, 35(8): 965-969.
46. 叶怀庄, 余运贤, 周旭东, 陈光弟, 章军, 金力奋, 曾群力. 高等学校公共卫生实验教学示范中心建设与体会. 中国高等医学教育. 2013, 1: 60-61.
47. 陈春静, 徐珊珊, 陈光弟, 许正平. 移动电话射频电磁场的遗传毒性效应. 中华劳动卫生职业病杂志. 2013,31(4): 306-309.
48. 许正平, 陈光弟. 细胞水平电磁场生物学效应研究的发展方向. 中华劳动卫生职业病杂志. 2012, 30 (3): 161-162.
49. 陈光弟, 鲁德强, 姜槐, 许正平. 工频磁场对人乳腺癌细胞基因表达的影响. 浙江大学学报（医学版）. 2008, 37(1): 15-22.
50. 王玲莉, 陈光弟, 鲁德强, 姜槐, 许正平. 1800MHz射频电磁场对人乳腺癌细胞基因表达的影响. 中华预防医学杂志. 2006, 40 (4): 159-163.
51. 曾群力, 翁瑜, 陈光弟, 鲁德强, 姜槐, 许正平. 1800MHz射频电磁场对人乳腺癌细胞蛋白质表达的影响. 中华预防医学杂志. 2006, 40 (4): 153-158.
52. 陈光弟, 许正平, 姜槐. 移动电话射频电磁场与健康关系的体外试验研究. 中华预防医学杂志. 2005, 39 (4): 285-287.
53. 陈光弟, 许正平, 姜槐. 酵母的电磁场生物学效应研究进展. 中华劳动卫生与职业病杂志. 2005, 23 (3): 235-237.
54. 叶怀庄, 李莉, 王明达, 陈光弟. 抗衰老保健食品的抗氧化活性检测. 浙江预防医学. 2004,16 (9): 26, 49.