Profile

Working experiences
1999-2002: Department of Physiology, Zhejiang University School of Medicne, Ph.D. candidate
2003-2009: Department of Physiology, Zhejiang University School of Medicne, Associate Professor
2009-present: Department of Pathophysiology, Zhejiang University School of Medicne, Associate Professor
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Research grants
1. Effect and mechanism of mitochondrial aldehyde dehydrogenase 2 on sepsis-induced heart injury. Natural Science Foundation of China（81272067） 2013.1-2016.12
2. Mechanism and effect of high glucose on LPS-induced endothelium injury. Zhejiang Provincial Natural Science Foundation of China（Y2100082） 2011.1-2013.12
3. Protective effect of puerarin aganist endoplasmic reticulum stress in diabetic vasculophy. Foundation of Education Department of Zhejiang Province of China （Y200908945） 2009.12-2011.12
4. Mechanism and effect of cycloogenase-2 inhibitor on oxidative injury in heart. National Natural Science Foundation of China（30400094）2005.1-2007.12

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Publications
1. Xu HJ, Chen WL, Wang Y, Zheng MZ, Chen YY, Shen YL. S262A mutation abolishes protective effects of connexin 43 against hypothermic preservation-induced injury in cardiomyocytes. J Heart Lung Transplant 2012, 31(6):663-669
2. Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP, Shen YL. Puerarin protects against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation in endothelial cells. Fund Clin Pharmacol 2012, 26(3):322-331
3. Yang F, Chen WL, Zheng MZ, Yu GW, Xu HJ, Shen YL, Chen YY. Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of bid in hypothermic preservation rat hearts. J Heart Lung Transplant 2011; 30(8): 928-34
4. Chen YY, Zheng MZ, Lv PP, Hu L, Wang LL, Shen YL. Hydrogen peroxide regulates glucose-regulated protein 78 expression via a cyclooxygenase-2 dependent mechanism. J Biochem Mol Toxicol 2010;24(5):279-285.
5. Meng XH, Ni C, Zhu L, Shen YL, Wang LL, Chen YY. Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta. Vascul Pharmacol. 2009, 50(3-4): 110-115.
6. Fang XD, Yang F, Zhu L, Shen YL,Wang LL, Chen YY. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clinical and Experimental Pharmacology and Physiology. 2009, 36(12): 1177-1182.
7. Yan ZK, Hu ZB, Pan XH, Chen YY, Zhang XM, Shen YL. Diazoxide supplemented Celsior solution improves hypothermic heart preservation effect in rat through activation of mitochondrial ATP-sensitive potassium channel. Pharmaceutical Biology. 2009, 47(11): 1060-1066.
8. Chen N, Shao W, Lv PP, Zhang SL, Chen YY, Zhu L, Lu Y, Shen YL. Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells. Free Radical Research. 2007, 41(9):990-6
9. Lv PP, Fan Y, Chen WL, Shen YL, Zhu L, Wang LL, Chen YY. COX-2 inhibitor nimesulide protects rat heart against oxidative stress by improving endothelial function and enhancing NO. Sheng Li Xue Bao. 2007, 59(5):674-680
10. Guo W, Chen N, Chen YY,, Xia Q, Shen YL. Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30.
11. Shen YL, Chen YY, Wu XD, Bruce IC, Xia Q. Activation of Mitochondrial ATP-Sensitive Potassium Channels Delays Ischemia-Induced Cellular Uncoupling in Rat Heart. Acta Pharmacologica Sinica, 2004, 25(1):22-28
12. Ke Y, Chen YY, Chang YZ, Duan XL, Ho KP, Jiang de H, Wang K, Qian ZM. Post-transcriptional expression of DMT1 in the heart of rat. J Cell Physiol. 2003, 196(1):124-30.
13. Chen YY, Ho KP, Xia Q, Qian ZM. Hydrogen peoxide enhances iron-induced injury in isolated heart and ventricular cardiomyocyte in rats. Mol Cell Biochem, 2002, 231(1-2): 61-68.