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Dr. Qichun WEI, Chair of department of Radiation Oncology, the Second affiliated hospital, Zhejiang University School of Medicine.
Dr. Wei graduated from Zhejiang University and Zhejiang Medical University, and is an employee of the Second affiliated hospital, Zhejiang University School of Medicine from 1992. He got the Degree of Doctor of Medical Science in Oncology at Zhejiang University in 2003. Dr. Wei worked at Uppsala University SWEDEN as a guest researcher from the May 2002 to April 2003, and visited Uppsala several times after that.
With the good radiotherapy facilities equipped, conventional radiotherapy, X-knife, conformal radiotherapy and intensive modulated radiotherapy (IMRT) are performed in the department. Radio-chemotherapy is also used as a routine. The aim of using radiation is to achieve cure with the preservation of normal anatomy and function, or, when cure is not possible, to maximize palliation.
As a specialist in Radiation Oncology, Dr. Wei mainly focuses on the diagnosis and therapy of head and neck cancer, including nasopharyngeal carcinoma. The incidence of esophageal carcinoma is high in China, so special attention is also given to esophageal malignancy. His current research interests are focused on tumor radiosensitization through drug delivery vehicle, such as nanomicelles and liposomes; and tumor targeting therapy research, combined with radiation, with aims to achieve cure with minimized side-effect and to explore suitable targets.
The research is economically supported mainly by National Nature Science Foundation of China and grants from Science and Technology Project of Zhejiang. Good support is also given from Zhejiang Provincial Medical Research Foundation, Zhejiang Provincial Traditional Chinese Medical Research Foundation, Zhejiang Provincial Education Bureau Research Foundation and The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry( SRF for ROCS, SEM).
Examples of publications:
1. Wei Q*, Sheng L, Shui Y, Hu Q, Nordgren H, Carlsson J. EGFR, HER2 and HER3 expression in laryngeal primary tumours and corresponding metastases. Ann Surg Oncol. 2008;15(4):1193-201.
2. Shang J, Shui Y, Sheng L, Wang K, Hu Q and Wei Q*. Epidermal growth factor receptor and human epidermal growth factor receptor 2 expression in parotid mucoepidermoid carcinoma: possible implications for targeted therapy. Oncol Rep. 2008;19(2):435-40.
3. Wei Q*, Shen L, Zheng S, Zhu Y. Isolation and characterization of a radiation-resistant lung cancer cell line. Biomedical and Environmental Sciences. 2008; 21: 339-44.
4. Shen L, Shui Y, Wang X, Sheng L, Yang Z, Xue D and Wei Q*. EGFR and HER2 expression in primary cervical cancers and corresponding metastases: implications for targeted radiotherapy. BMC Cancer, 2008; 8(1): 232.
5. Sheng L, Shui Y, Shen L, Wei Q*. Effect of patient-related delay in diagnosis on the extent of disease and prognosis in nasopharyngeal carcinoma. Am J Rhinology. 2008; 22:317-20.
6. Rao C, Hu Q, Ma J, Li J, Zhang C, Shen L and Wei Q*. Comparison of the epidermal growth factor receptor protein expression between primary non-small cell lung cancer and paired lymph node metastases: implications for targeted nuclide radiotherapy. J Exp Clin Cancer Res. 2010; 22(1):7
7. Shang J, Sheng L, Wang K, Shui Y and Wei Q*. Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. Oncol Rep. 2007; 18(6):1413-6.
8. Wei Q*, Chen L, Sheng L, Nordgren H, Wester K, Carlsson J. EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases. Int J Oncol. 2007; 31(3):493-9.
9. Liu JR, Huang J, Zhang M, Wei QC, Song Y, Huang JZ, Ding MP, Jia PJ. Medullary hemorrhagic infarction after radiation for nasopharyngeal carcinoma. Intern Med. 2007; 46(9):611-5.
10. Wei Q*, Kullberg EB, Gedda L. Trastuzumab-conjugated boron-containing liposomes for tumor-cell targeting; development and cellular studies. Int J Oncol. 2003;23(4):1159-65.
11. Kullberg EB, Wei Q, Capala J, Giusti V, Malmstrom P, Gedda L. EGF-receptor targeted liposomes with boronated acridine: Growth inhibition of cultured glioma cells after neutron irradiation. Int J Radiat Biol. 2005;81(8): 621-9.
12. Tolmachev V, Orlova A, Wei Q, Bruskin A, Carlsson J, Gedda L. Comparative biodistribution of potential anti-glioblastoma conjugates [111In]DTPA-hEGF and [111In]Bz-DTPA-hEGF in normal mice. Cancer Biother Radiopharm. 2004;19(4):491-501.
13. DOX loaded PEG-PCL copolymer micelles enhanced the cytotoxicity and the intracellular accumulation of drug in DOX-resistant tumor cells.submitted