Profile

CURRICULUM VITAE


PERSONAL DATA

Name: Yu-Feng Yao, M.D., Ph.D.


POSITION: Professor and Chairman


INSTITUTION: Department of Ophthalmology
Sir Run Run Shaw Hospital
Zhejiang University School of Medicine

ADDRESS: 3 Qingchun Road East
Hangzhou, Zhejiang,
P. R. China
Zip Code: 310016
Tel. 86-571-86002002
Fax. 86-571-86044817
Email. yaoyuf@mail.hz.zj.cn


EDUCATION

1979-1984 M.D. obtained from Faculty of Medicine,
Zhejiang Medical University

1992-1997 Ph.D. obtained from Osaka University Medical
School, Japan:--Thesis: induced anterior chamber-associated immune deviation in suppression of corneal graft rejection. Supervisors: Yoshitsugu Inoue, Yuich Ohashi, and Yasuo Tano


PROFESSIONAL QUALIFICATIONS / MEMBERSHIPS

1. Committee member: Corneal Disease Group, Ophthalmology, Chinese Medical Society
2. Committe Member of Chinese National Doctor Society
3. Juninor committee member: Chinese Ophthalmological Society
4. Vice President: Ophthalmological Society of Zhejiang Province
4. Life Member: Association for Research in Vision and Ophthalmology
5. Member: International Ocular Surface Society
6. Member: American Academy of Ophthalmology


WORK EXPERIENCE

Jan. 1998 to date: Professor and Chairman, Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, China

Oct. 1995: Associate professor, Department of Ophthalmology, Second Affiliated Hospital, Zhejiang Medical University, Zhejiang, China

Apr. 1993-April 1995: Research Associate, Department of Ophthalmology, Osaka University Medical School, Japan

Jan. 1990: Assistant professor, Department of Ophthalmology, Second Affiliated Hospital, Zhejiang Medical University, Zhejiang, China

1985-1990 : Teaching assistant, Department of Ophthalmology, Second Affiliated Hospital, Zhejiang Medical University, Zhejiang, China

1984-1985 : Resident, Second Affiliated Hospital, Zhejiang Medical University, Zhejiang, China


PUBLICATIONS

1. Yin JF, Jiang JK, Yao YF. Methycellulose as intraocular viscous elastic material in animal study. Journal of Zhejiang Medical University. 19(4):167-169, 1990 (in Chinese)
2. Yao YF, Yin J-F. Castroviejo syndrome: a case report. Journal of Zhejiang Medical University. 21(2):94, 1992 (in Chinese)
3. Yao K, Yao YF. Comparison of primary and secondary cataract removal and intraocular lens in penetrating keratoplasty cases. Journal of Zhejiang Medical University. 21(2):67-69, 1992 (in Chinese)
4. Yao YF, Inoue Y, Shimomura Y, Hosotani H, Kase T. Three cases of atypical keratitis caused by herpes simplex virus type 1. J. Eye (Atarashi Ganga). 10(10):1711-1714, 1993. (in Japanese)
5. Yao YF, Inoue Y, Shimomura Y, Hosotani H, Kase T. Primary herpes simplex virus infection with geographic conjunctival ulceration. Am J Ophthalmol. 118(11):670-671, 1994
6. Yao YF, Inoue Y, Hara Y, Kiritoshi A, Tano Y, Ohashi Y. Suppression of graft rejection in rat keratoepithelioplasty by anterior chamber inoculation of donor lymphocytes. Jpn J Ophthalmol. 38:345-352, 1994.
7. Yao YF, Inoue Y, Miyazaki D, Shimomura Y, Ohashi Y, Tano Y. Ocular resurfacing and alloepithelial rejection in a murine keratoepithelioplasty model. Invest Ophthalmol Vis Sci. 36:2623-2633, 1995.
8. Yao YF, Inoue Y, Shimomura Y, Kiritoshi A, Ohashi Y. Suppressive effect of FK506 on corneal epithelial rejection in a murine keratoepithelioplasty model. Folia Ophthalmol Jpn. 45: 976-980, 1995 (in Japanese)
9. Shimomura Y, Yamamoto S, Yao YF, Hosotani H, Kiritoshi A, Inoue Y. Herpes simplex virus DNA detection from tear film of herpetic keratitis in non-active stage. Folia Ophthalmol Jpn. 45:481-483, 1994. (in Japanese)
10. Shimomura Y, Yamamoto S, Yao YF, Inoue Y, Ohshima T. Effectiveness of polymerase chain reaction in herpetic latency in the human cornea. Journal of the Eye (Atarashi Ganga). 10(11):1869-1871, 1993. (in Japanese)
11. Kiritoshi H, Inoue Y, Neze E, Cho Y, Shimomura Y, Yao YF. A case of atypical herpetic epithelial keratitis under treatment for rejection after penetrating keratoplasty. Journal of the Eye (Atarashi Ganka). 11(12):1923-1925, 1994. (in Japanese)
12. Uno T, Ohashi Y, Inoue Y, Yao YF, Ishii Y. A case of recurrent corneal epithelial opacity originating from the limbus. Rinsho Ganka (Jpn J Clin Ophthalmol). 48(4):709-713, 1994. (in Japanese)
13. Yao YF, Inoue Y, Kase T, Uchihori Y, Mori Y, Ohashi Y. Clinical characteristics of acyclovir-resistant herpetic keratitis and experimental studies of isolates. Graefe’s Arch Clin Exp Ophthalmol. 234:S126-S132. 1996
14. Yao YF, Inoue Y, Shimomura Y, Hosotani H, Kase T. A case of geographic conjunctival ulcer caused by primary infection of herpes simplex virus type 1. Rinsho Ganka (Jpn J Clin Ophthalmol). 48(3):326-327, 1994. (in Japanese)
15. Yao YF, Inoue Y, Miyazaki D, Hara Y, Shimomura Y, Tano Y, Ohashi Y. Correlation of anterior chamber-associated immune deviation with suppression of corneal epithelial rejejction in mice. Invest Ophthalmol Vis Sci. 38:292-300, 1997.
16. Yao YF, Inoue Y, Miyazaki D, Hara Y, Shimomura Y, Tano Y, Ohashi Y. The antigen-bearing eye and the spleen are indispensable in maintaining anterior chamber-associted immune deviation. Invest Ophthalmol Vis Sci. 38:534-3539, 1997.
17. Hara Y, Yao YF, Tano Y. Transforming growth factor-B endows macrophages with a deviant systemic immune response similar to anterior chamber-associated immune deviation. Regional Immunology. 6 (1&2):138-142, 1994.
18. Inoue Y, Yao YF. Mouse keratoepithelioplasty model. 1st annual meeting of the Kyoto Cornea Club, Kyoto, December 1-2, 1995, pp93-100. Ed. Kinoshita S and Ohashi Y.
19. Miyazaki D, Inoue Y, Yao YF, Okada A, Shimomura Y, Hayashi K, Tano Y, Ohashi Y. T-cell-mediated immune responses in alloepithelial rejection after murine keratoepithelioplasty. Invest Ophthalmol Vis Sci. 40:2590-2597, 1999.
20. Yao YF, Zhang B, Zhou P, Jiang JK. Autologous Limbal Grafting Combined with Deep Lamellar Keratoplasty in Unilateral Eye with Severe Chemical or Thermal Burn at Late Stage. Ophthalmology 2002; 109(11):2011-2017
21. Yao YF, Zhang YM, Zhou P, Zhang, Qiu WY, Tseng SCG. Therapeutic Penetrating Keratoplasty in Severe Fungal Keratitis Using Cryopreserved Donor Corneas. Br J Ophthalmol 2003;87:543-547
22. Zhang B, Yao YF. Application of impression cytology in diagnosis of ocular surface disease. Journal of Zhejiang University (Medical Science) 2002; 31:383-387 (in Chinese)
23. Han CM, Yao YF, Yu CH. Treatment of the ocular burn with hormone. Chin J Burns. 2001; 17:330-332 (in Chinese)
24. Yao YF, et al. Descemet’s Membrane Exposure in Full Bed by a Technique of Viscoelastic Injection through a Pocket for Deep Lamellar Keratoplasty. Invest Ophthalmol Vis Sci. 2003; 44: E-Abstract 4664. ARVO Abstract. May 2003 in Fort Lauderdale, FL. USA
25. Zhu YF, Yao YF, Qiu WY. Combination of Auto-Limbal Grafting with Deep Lamellar Keratoplasty for Unilateral Ocular Burn. Chinese Ophthalmic Research. 2004; 22: 395-398. (in Chinese).
26. Zhou P, Yao YF, Qiu WY, et al. Optical Penetrating Keratoplasty in Eyes with Severe Keratomycosis after Therapeutic Keratoplasty. Chinese Journal of Ophthalmology. 2005; 41:1103-1106. (in Chinese).
27. Qiu WY, Yao YF, Zhu YF, Zhang YM, Zhou P, Jin YQ and Zhang B. Fungal Spectrum Identified by a New Slide Culture and In Vitro Drug Susceptibility Using Etest in Fungal Keratitis Current Eye Research 2005; 30:1113–1120.
28. Yao YF, Qiu WY, Zhang YM, Tseng SCG. Mitomycin C, Amniotic Membrane Transplantation and Limbal Autograft in Treating Recurrent Pterygia with Severe Symblepharon and Motility Restriction. Graefe’s Arch Clin Exp Ophthalmol 2006; 244:232-236.
29. Tong JP, Yao YF. Contribution of VEGF and PEDF to choroidal angiogenesis: A need for balanced expressions. Clinical Biochemistry 2006 (39) 267-276
30. Yao YF, Jin YQ, Zhang B, Zhou P, Zhang YM, Qiu WY, Mou SL, Wu LQ. Recurrence of Corneal Lattice Dystrophy due to Incomplete Removal of Stroma after Deep Lamellar Keratoplasty. Cornea. 2006; 25:S41-6.
31. Ye YF, Yao YF, Zhou P, Pan F. In vivo confocal microscopy of pre-Descemet's membrane corneal dystrophy. Clin Experiment Ophthalmol. 2006; 34(6):614-6.
32. Ye YF, Yao YF, Zhou P, et al. Observation of Healing Process of Corneal Epithelial Basal Cells after Full-Bed Deep Lamellar Keratoplasty with Confocal Microscopy. Chinese Ophthalmic Research. 2006; 24: 651-653. (in Chinese).
33. Zhang B, Yao YF, Zhou P. Two novel mutations identified in two Chinese gelatinous drop-like corneal dystrophy families. Molecular Vision. 2007; 13:988-992.
34. Yao YF. A Novel Technique for performing full-bed deep lamellar keratoplasty. Cornea 2008; 27:S19-24.
35. Huo YN, Qiu WY, Pan Q, Yao YF, Xing K, Lou MF. Reactive oxygen species (ROS) are essential mediators in epidermal growthfactor (EGF)-stimulated corneal epithelial cell proliferation, adhesion, migration, and wound healing Experimental Eye Research 2009; 89:876-886


CHAPER IN BOOKS
1. Inoue Y, Yao YF. Mouse keratoepithelioplasty model. 1st annual meeting of the Kyoto Cornea Club, Kyoto, December 1-2, 1995, pp93-100. Ed.by Kinoshita S and Ohashi Y.
2. Yao YF: Drug toxicity induced Ocualr Surface Disorders. published by People's Medical Publishing House. Ed. by Liu Zuguo. Ocular Surface Disease 2003, P.547-551.
3. Yao YF: Contact Lense Related Complications and Management. published by People's Medical Publishing House. Ed. by Lu Fan. Contact Lense. 2004
4. Yao YF. Deep Lamellar Keratoplasty Combined with Autologous Limbal Grafting in Treating Unilaterally Severe Burnt Eye. Ed. by Thomas John. Jaypee Brothers Medical Publication (P) LTD. Surgical Techniques in Anterior and Posterior Lamellar Corneal Surgery. 2006, pp663-671.


COURSES TAUGHT

1995 to 1998: Corneal Diseases, Cataract at Second Affiliated Hospital, Zhejiang Medical University
1998 to 2010: Pandect of Ophthalmology, Corneal Diseases, Update in Corneal Disease Management

For Undergraduate, Graduate Students and Postdoctoral Fellow Trained



HONORS AND AWARDS

1. in year of 1998: Young Scientist Award in First World Chinese Ophthalmological Meeting, in Beijing
2. in year of 2005: Zhejiang Provincial Science and Technologic Progressional Award (Second Grade)
3. in year of 2005: Zhejiang Public Health Progressional Award (Second Grade)
4. in year of 2010: Zhejiang Public Health Progressional Award (First Grade)



SPECIALTY and INTERESTED AREA

1. Corneal & External Eye Diseases
2. Development of Corneal Surgical Techniques
3. Corneal Infectious Disease: Herpes simplex virus and Fungi
4. Ocular Surface Disorders and Ocular Surface Reconstruction
5. Ocular Immunology


RESEARCHES CURRENT UNDERWAY

1. Study of Ocular Surface Reconstruction Strategy and Its Mechanisms
2. Study of Fungal strains and Corneal Infectious Mechanism
3. Mechanism of Corneal Epithelial Wound Healing