Profile

The formation of functional neural circuits is orchestrated by multiple innate genetic programs and shaped by environmental stimuli. A failure in one of these mechanisms may lead to dysfunction in the central nervous system (CNS). We are interested in investigating abnormal brain circuit formation associated with spontaneous and acquired neurological conditions.

EDUCATION

Tufts University, Sackler School of Graduate Biomedical Sciences, Boston, MA
• Ph.D. in Neuroscience 2003

Chinese Academy of Sciences, Shanghai Brain Research Institute, Shanghai, China
• M.S., Neurobiology 1996

Hangzhou University, Zhejiang, China
• B.S., Biology 1993

PROFESSIONAL POSITIONS

Zhejiang University School of Medicine, Department of Neurobiology
• 2011-, Professor of Neurobiology

Harvard Medical School, Departments of Neurology and Pathology
• 2010-2011, Instructor in Pathology
• 2006-2010, Research Fellow

Boston University, Department of Biomedical Engineering
• 2003-2006, Research Associate

Selected Publications

1. Yu-Dong Zhou, Dawei Zhang, Ekim Ozkaynak, Xuan Wang, Ekkehard M. Kasper, Eric Leguern, Stéphanie Baulac, Matthew P. Anderson. Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses. Journal of Neuroscience, 2012, 32: 903-910.

2. Artur Czupryn*, Yu-Dong Zhou*, Xi Chen*, David McNay, Matthew P. Anderson, Jeffrey S. Flier, Jeffrey D. Macklis. Transplanted Hypothalamic Neurons Restore Leptin Signaling and Ameliorate Obesity in db/db Mice. Science, 2011, 334: 1133-1137. (*: equal contribution).

3. Stephen E.P. Smith, Yu-Dong Zhou, Guangping Zhang, Zhe Jin, David C. Stoppel, Matthew P. Anderson. Increased Gene Dosage of Ube3a Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice, Science Translational Medicine, 2011,3: 103ra97.
Comment in Simons Foundation: http://sfari.org/news-and-opinion/news/2011/two-new-autism-mouse-models-highlight-gene-dosage-effects
News in Science: http://www.aaas.org/news/releases/2011/1005sp_mouse_autism.shtml?sa_campaign=Internal_Ads/AAAS/RSS_News/2011-10-05/

4. Yu-Dong Zhou, Sanghoon Lee, Zhe Jin, Moriah Wright, Stephen E.P. Smith, Matthew P. Anderson. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy, Nature Medicine, 2009, 15: 1126–1127.
Comment in: Nature Medicine 15: 1126–1127, 2009.
News in brief: Lancet Neurology 8: 888, 2009.

5. Tara Keck, Kyle P. Lillis, Yu-Dong Zhou, John A. White. Frequency-dependent Glycinergic inhibition modulates plasticity in hippocampus, Journal of Neuroscience, 2008, 28: 7359–7369.

6. Yu-Dong Zhou, Corey D. Acker, Theoden I. Netoff, Kamal Sen, John A. White. Increasing Ca2+ transients by broadening postsynaptic action potentials enhances timing-dependent synaptic depression, Proceedings of the National Academy of Sciences USA, 2005, 102: 19121-19125.
Recommended by Faculty of 1000, 2006.

7. Zhou YD, Turner TJ and Dunlap K. Enhanced G protein-dependent modulation of excitatory synaptic transmission in cerebellum of the Ca2+ channel mutant mouse, tottering. Journal of Physiology, 2003, 547: 497-507.
Comment in: Current Opinion in Neurobiology 2005, 15: 257-265, of special interest.

8. Tsen G, Williams B, Allaire P, Zhou YD, Ikonomov O, Kondova I and Jacob MH. Receptor with opposing functions are in postsynaptic microdomains under one presynaptic terminal. Nature Neuroscience, 2000, 3: 126-132.