The expression of histamine receptor 1-4 (H1- 4R) and histamine methyltransferase was determined in the histamine projection areas which are strongly involved in Parkinson’s disease (PD), i.e. the substantia nigra and striatum, with quantitative polymerase chain reaction and immunocytochemistry. In addition, the relationship between the expression of these molecules and PD pathologies and disease course were analyzed. We found for the first time brain-area-specific changes of neuronal histaminergic system in PD. This may provide scientific evidence for novel therapeutic strategies. The paper was published in Neurobiology of Aging.
On March 5, the research team led by Professors YU Yanqin, DUAN Shumin and YANG Hongbin from the Zhejiang University School of Brain Science and Brain Medicine published an op...
A team of researchers from the Bird 10,000 Genomes (B10K) consortium, initiated by Professor ZHANG Guojie of Centre for Evolutionary & Organismal Biology at Zhejiang University and collaborators, ...
Myocardial hypertrophy, characterized by an increase in cardiac muscle mass, is an adaptive response to pathological stimuli such as hypertension and valve disease. While initially beneficial, sustain...
