Professor Chao He and his group firstly compared the secretome of fresh cultured CRC tumor tissues and paired normal colorectal (NC) tissues under near physiological conditions. They applied a lectin affinity based approach to enrich secreted proteins in the conditioned media of cultured tissues. The captured proteins were analyzed by the proteomic strategy of one-dimensional gel electrophoresis coupled to liquid chromatography−tandem mass spectrometry. They found 123 expressed secreted proteins (DESPs) between the CRC tissues and NC tissues. Compared with previous studies on functional genomics and proteomics, EFEMP2 was identified as a promising novel serum biomarker for CRC early detection by further research. The study was published in the Journal of Proteome Research.
On March 5, the research team led by Professors YU Yanqin, DUAN Shumin and YANG Hongbin from the Zhejiang University School of Brain Science and Brain Medicine published an op...
A team of researchers from the Bird 10,000 Genomes (B10K) consortium, initiated by Professor ZHANG Guojie of Centre for Evolutionary & Organismal Biology at Zhejiang University and collaborators, ...
Myocardial hypertrophy, characterized by an increase in cardiac muscle mass, is an adaptive response to pathological stimuli such as hypertension and valve disease. While initially beneficial, sustain...
