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基本信息:

姓名: 张进
职务: PI
职称: 研究员
学历: 博士
专业:
所属院系: 基础医学系
研究方向: 干细胞多能性维持的分子机制,基因调控网络与代谢网络相互作用对细胞命运的影响,iPS疾病模型的建立,以及干细胞分化免疫细胞的机制研究和临床转化。
电话:
信箱: zhgene@163.com
个人主页:

个人简介:


张进,现任浙江大学医学院百人研究员,博士生导师,青年千人。


2011年于加州大学洛杉矶分校取得博士学位。

2012-2017年于哈佛大学医学院/波士顿儿童医院从事多能干细胞的研究工作。

2016-2017年担任美国生物技术公司安进公司科学家,负责建立iPS新药靶点发现平台。


现主要研究方向为干细胞多能性维持的分子机制,基因调控网络与代谢网络相互作用对细胞命运的影响,iPS结合基因编辑进行疾病模型的建立,干细胞分化免疫细胞的机制研究和临床转化。


曾获得美国加州再生医学研究院的独立经费支持。在干细胞相关领域相关文章以第一作者或通讯作者身份发表于Cell Stem Cell, Cell Report, EMBO Journal, Nature Protocol等杂志。共同作者文章发表于Nature, Cell, Science, PNAS等杂志.


多次在国际和国内学术会议上报告,包括2016年受邀为国际干细胞研究协会(ISSCR)年会报告人.


Publications

 

Chandrasekaran, S*, Zhang, J.*,  Ross, C.A., Huang, Y., Asara, J. M., Hu, L., Daley G.Q.,Collins, J.J.  Reconstruction and Manipulation of the Pluripotent Stem Cell Metabolic Network. accepted

 

Zhang, J.*, Nioi, P., Hu, L., Tounsen, A., Wu, C. J. Human Stem Cell Models Facilitate Translating Human Genetics to Drug Development. 2017 Aug. 3; 21,2, p161-165, Cell Stem Cell

 

Zhang, J.*, Ratanasirintrawoot, S.*, Chandrasekaran, S, Wu, Z., Ficarro, S.B., Yu, C., Cacchiarelli, D., Ross, C.A., Xia, Q., Seligson,M, Shinoda, G., Xie, W., Cahan, P., Wang, L., Shyh-Chang, N., Tintara, S., Trapnell, C., Onder, T., Loh, Y., Asara, J.M., Mikkelsen, T., Teitell, M., Sliz P., Marto, J.M., Hu, L., Collins, J.J., Daley, G. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. 2016 July 7; 19, 1-15, Cell Stem Cell


Zhang, J., Neuble, E., Daley, G.Q., Koehler, C.M., Teitell. M.A. Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-renewal, Cell Stem Cell, 2012, 11(5): 589-95


Zhang, J., Hong, J.S., Vergnes L., Reue, K., Koehler, C.M., and Teitell, M.A. UCP2 Regulates Energy Metabolism in Human Pluripotent Stem Cells, EMBO Journal, 2011, 30(24):4860-73


Zhang, J. Neuble, E., Wisidagama, R., Malone, C., Teitell, M.A. Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells, Nature Protocols, 2012 7(6): 1068-85


Xie, Y., Zhang, J., Lin, Y., Meng, X., Wisidagama, D.R.R., Cinkornpumin, Koehler, C.M., Malone, C.S., Teitell, M.A., and Lowry, W.E. Defining Role of Oxygen Tension in Human Neural Cell Fate. 2014 Nov 11; 3(5): 743–757, Stem Cell Reports, 2014

 

Kumar, K., Cahan, P., Shalek, A., Satija, R., Li, H, Zhang, J., Pardee, K., Gennert, D., Trombetta, J., Ferrante, T., Regev, A., Collins, J., Daley, G. Deconstructing transcriptional heterogeneity in pluripotent stem cells. 2014 Dec 4; 516(7529): 56-61, Nature, 2014

 

Urbach, A., Yermalovich, A., Zhang, J., et. al. Daley, G. Lin28 sustains early renal progenitors and induces Wilms tumor Gene & Development, 2014, 28(9):971-82

 

Zangle, T.A., Chun, J., Zhang, J., Reed, J., Teitell, M. Quantification of Biomass and Cell Motion in Human Pluripotent Stem Cell Colonies, Biophysical Journal, 2013, 105(3): 593-601


Cherry A.B., Gagne K.E., McLoughlin E.M., Baccei A, Gorman B, Hartung O, Miller J.D., Zhang J, Zon R.L., Ince T.A., Neufeld E.J., Lerou P.H., Fleming M.D., Daley G.Q., Agarwal S., Induced pluripotent stem cells with a mitochondrial DNA deletion, Stem Cells, 2013, 31(7): 1287-97

 

Shyh-Chang N, Locasale J.W., Lyssiotis C.A., Zheng Y., Teo R.Y., Ratanasirintrawoot S., Zhang J., Onder T., Unternaehrer J.J., Zhu H., Asara J.M., Daley G.Q., Cantley L.C. Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation. Science, 2012, 339(6116):222-6

Wang, G., Shimada, E., Zhang, J., Hong, J.S., Smith, M.G., Teitell, M.A., Koehler, C.M. Correcting Mitochondrial Mutations with Targeted RNA Import, PNAS, 2012, 109 (13): 4840-5

Wahjudi, P.N., Yee, Y., Martinez, S.R., Zhang, J., Teitell, M.A., Nikolaenko, L., Swerdloff, R, Christina, W., Lee, W.N.P. Turnover of non-essential fatty acids in cardiolipin from the rat heart, Journal of Lipid Research, 2011, 52(12): 2226-33

Wang, G., Chen, H., Oktay, Y., Zhang, J., Allen, E.L., Smith, G.M., Fan, K.C., Hong, J.S., French, S.W., McCaffery, J.M, Lightowlers, R.N., Morse III, H.C., Koehler, C.M., and Teitell, M.A. PNPASE Regulates RNA Import into Mitochondria. Cell, 2010 142;3: 456-467 


Chin, M., Mason, M., Xie, W., Volinia, S., Singer, M., Peterson, C., Clark, A., Richter, L., Aimuwu, O., Zhang, J., Khvorostov, I., Ott, V., Grunstein, M., Benvenisty, N., Croce, C., Clark, A., Baxter, T., Pyle, A., Teitell, M., Pellegrini, M., Plath, K., and Lowry, W. Induced Pluripotent Stem Cells and Embryonic Stem Cells are Distinguished by Gene Expression Signatures. Cell Stem Cell, 2009 2;5(1):111-23 


Zhang, J., Khvorostov, I.B., and Teitell, M.A. From MEFs to Matrigel 1: Passaging hESCs in the Presence of MEFs. Journal of Visualized Experiments, 2008 

Khvorostov, I.B., Zhang, J., and Teitell, M.A. From MEFs to Matrigel 2: Splitting hESCs from MEFs onto Matrigel. Journal of Visualized Experiments, 2008

Zhang, J., Khvorostov, I.B., and Teitell, M.A. From MEFs to Matrigel 3: Passaging hESCs from Matrigel onto Matrigel. Journal of Visualized Experiments, 2008

Khvorostov, I.B., Zhang, J., and Teitell, M.A. Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells. Journal of Visualized Experiments, 2008