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基本信息:

姓名: 范伟民
职务: 实验室主任
职称: 教授
学历: 博士
专业: 肿瘤学
所属院系: 浙医一院
研究方向: 实验肿瘤治疗,纳米生化药物
电话: 0571-88208778
信箱: fanw@zju.edu.cn
个人主页: http://www.musc.edu/pathology/website/people/individual/fan.html

个人简介:

学习经历

  1978-1983 浙江医科大学医学系本科学生

  1983-1986 浙江医科大学公共卫生学系硕士研究生

  1986-1988 美国迈阿密大学医学院微生物和免疫系 博士研究生

  1988-1990 美国南卡罗莱纳大学医学院微生物和免疫系 博士研究生

  1990-1992 美国南卡罗莱纳医科大学风湿病和免疫学 博士后

工作经历:

  1992-1997 美国南卡罗莱纳医科大学内科及病理与实验医学系 助理教授

  1992-2014 美国南卡罗莱纳医科大学研究生院 博士生导师

  1994-2014 美国南卡罗莱纳医科大学Hollings癌症中心 Full Member

  1997-2003 美国南卡罗莱纳医科大学病理与实验医学系及内科系 副教授

  2003-2014 美国南卡罗莱纳医科大学病理与实验医学系及内科系 教授

  2004-2005 教育部春晖计划讲座教授(浙江大学医学院)

  2005-2008 浙江大学兼职教授,肿瘤学博士生导师

  2008-目前 浙江大学求是特聘教授,博士生导师

 

学科专长 肿瘤生物学, 分子免疫学, 实验肿瘤治疗,纳米药物

研究方向 肿瘤生物学, 激素对肿瘤生长和治疗的影响,肿瘤靶向治疗,纳米抗感染药物

 

学术团体和社会兼职:

1)学术团体和专业协会会员:美国癌症研究协会; 美国细胞生物学协会; 美国内分泌协会; 国际预防肿瘤学协会; 美国分子药理协会; 美国药理和实验治疗协会; 中国北美华人生物科学家协会。浙江省首批海外高层次人才(千人计划)入选者(2009)

 

 

2)科学基金和学术评审委员会: 美国国家卫生研究院肿瘤研究所(NIH/NCI)科研基金评审委员; 英国肿瘤研究基金Ad Hoc评审委员; 美国国防部乳乳腺癌和前列腺癌研究基金评审委员会评审委员; 美国Susan Komen乳腺癌研究基金Ad Hoc评审委员; 美国癌症研究协会(AACR)临床和转化医学基金评审委员;新加坡国家医学研究委员会, 中国自然科学基金药物与药理学重点项目海外评审委员; 中国科技部创新人才推进计划,教育部人事司“长江学者奖励计划”通讯评审专家等。学术期刊编委和稿件评审人:浙大科学 (Zhejiang University ScienceChina);实用肿瘤学 (Practical OncologyChina, Associate Editor);国际肝胆胰疾病杂志 (HBPD InternationalChina, International Editorial Board)Journal of Cancer Research and Therapy (Member of Editorial Board): Cancer Research (USA); Clinical Cancer research (USA)Molecular Cancer Therapeutics (USA); American Journal of Pathology (USA)Biochemical Pharmacology (USA)Carcinogenesis (UK)Journal of Histochemistry & Cytochemistry (USA)Journal of Biological Chemistry (USA)Oncogene (UK)International Journal of Cancer (Germany)Oncology Research (USA)International Journal of Hematology (Japan)Cancer Letter (UK)British Pharmacology (UK)Molecular Pharmacology (USA)Journal of Pharmacy and Pharmacology (Germany)BMC Cancer (UK);OncogeneGermany),NanoToday SG);Cell Death and Differentiation (UK);NanoMedicine (UK) 等等。

 

早期在美国所发表的代表性论文(共约60篇)

1.    Fan W., Kasahara M., Gutknecht J., Klein D., Jonkers J., and Klein J. Shared class II MHC polymorphisms between human and chimpanzees. Human Immunol. 26:107-121, 1989

2.   Kasahara M, Klein D, Fan W, Gutknecht J.Evolution of the class II major histocompatibility complex alleles in higher primates, Immunol Rev. 113:65-82.1990

3  Fan W., Trifilette R. Cooper T. and Norris JS. Cloning of a µ class glutathione S-transferase gene and identification of the glucocorticoid regulatory domains in its 5flanking region. Proc. Natl. Acad. Sci. U.S.A. 89:6104-6108, 1992

4.   Fan, W., Cooper, T. and Norris, JS. Characterization of selective glucocorticoid dependent responses in a glucocorticoid resistant smooth muscle tumor cell line. J. Cell. Physiol. 156:88-95, 1993

5.   Johnson KR., Wang L., Miller MC., Willingham MC. Fan W.* 5-Flurouracil interferes with paclitaxel cytotoxicity against human solid tumor cells. Clin. Cancer Res. 3:1739-1745, 1997

6.    Fan W.*, Ma JX. and Norris JS. Molecular cloning of TA16, a transcription repressor, that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells, Mol. Endocrin. 11:1342-1352, 1997

7.    Fan, W.*, Kou, H., Shen, D. and LeRoy, EC. Identification of altered expression of ADT/ATP translocase and laminin during cellular senescence in vitro. Exp. Geront. 33:457 465, 1998

8.   Johnson RK., Young KK, and Fan W.* Antagonistic interplay between anti-mitotic and G1/S arresting agents in experimental combination therapy. Clin. Cancer Res. 5:2559-2565, 1999

9.   Fan W.* Possible mechanisms of paclitaxel-induced apoptosis, Biochem. Pharmacol, 57:1215-1221, 1999

10.   Huang Y. Johnson RK, Norris JS. and Fan W.* Nuclear factor-kappaB/I-kB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432, 2000

11.   Zeng S., Chen YZ, Johnson, KR. and Fan W.* In vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin. Cancer Res. 6:3766-3773, 2000

12.  Huang Y. and Fan, W.* IkB kinase activation is involved in the regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol. 61:105-113, 2002

13.   Sui M., Dziadyk J., Zhu XM, and Fan W.* Cell cycle dependent antagonistic interactions between paclitaxel and gama-radiation in combination therapy. Clin. Cancer Res. 10:4848-4857, 2004

14 Fan W.* Sui M. and Huang Y. Glucocorticoids inhibit taxane-induced apoptosis: Mechanisms and clinical impact. Curr. Med. Chem. 11:403-411, 2004

15.   Huang Y. Fang Y. Wu J., Dziadyk J., Zhu XM, Sui M., and Fan W.* Regulation of vinca alkaloid-induced apoptosis by NF-kappaB/IkB pathway in human tumor cells. Mol. Cancer Therap. 3: 271-277, 2004.

16 Sui M. and Fan W.* Combination of gamma-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest ad apoptosis. Int. Radio. Oncol. Phy. Bio. 1151-1158, 2005

17.   Sui M., Chen F., Chen Z. and Fan, W.* Glucocorticoids interfere the therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer. 119-712-717, 2006

18.   Sui M. Huang Y., Park BH, Davidson NE., Fan W.* Estrogen receptor-alpha mediates breast cancer cells resistance to paclitaxel through inhibition of apoptotic cell death. Cancer Res. 67: 5337-5344, 2007.

 

加盟浙江大学医学院后所发表的学术论文2008 - Present

1.    Wang L. Jiang Z, Sui M, Shen J, Xu C and Fan W.* The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study. BMC Cancer, 9:226-235. 2009 (IF 3.32)

2.    Liu L, Xu K, Wang H, Tan PK, Fan W, Venkatraman SS, Li L and Yang YY, Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. Nature Nanotechnol. 4:457-463. 2009 (IF 33.26)

3.     Li CL, Jiang J, Fan YQ, Fu GS, Wang JA, Fan W. Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice. J Chin Med (Engl). 122:566-570, 2009

4.      Xu W, Xi B, Wu J, An H, Zhu J, Abassi Y, Feinstein AC, Geng B, Yan H, Sui M, Fan W, Wang X, and Xu X. Natural Product Derivative, Bis(4-fluorobenzyl)trisulfide Inhibits Tumor Cell Growth by Modification of β-tubulin at Cys 12 and Suppression of Microtubule Dynamics, Mol Cancer Therapy, 8(12):3318-3330, 2009 (IF 6.11)

5.    Wang J, Sui M and Fan W.* Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics. Current Drug Metab. 11(2): 129-141, 2010 (IF 5.11)

6.    Song H, Yang j, Lo S, Wang Y., Fan W, Tang W, Xue J and Wang S. Nonviral Magnetofection Using Self-assembled Ternary Complexes of Cationic Magnetic Particle, Plasmid DNA and Andosomolytic Tat Peptide, Biomaterials, 31:769-778, 2010 (IF 8.31)

7.    Ma K, Hu M, Xie M, Shen H, Qiu L, Fan W, Sun H, Chen S, Jin Y.* Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems. J Gene Med. Aug;12(8):669-680. 2010 (IF 3.08)

8.    Sui M, Jiang D, Hinsch C and Fan W.* Fulvestrant (ICI 182,780) sensitizes breast cancer cells expressing estrogen receptor alpha to vinblastine and vinorelbine. Breast Cancer Res Treat. 121(2);335-345, 2010 (IF 4.20)

9.    Wang H, Xu K, Liu L, Tan JP, Chen Y, Li Y, Fan W, Wei Z, Sheng J, Yang YY and Li L. The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis. Biomaterials. 31: 2874-2881, 2010 (IF 8.31)

10.  Xu K, Wang H, Liu L, Xu W, Sheng J, Fan W, Yang Y, Li L. Efficacy of CG(3)R(6)TAT nanoparticles self-assembled from a novel antimicrobial peptide for the treatment of candida albicans meningitis in rabbits. Chemotherapy. 19;57(5):417-425, 2011 (IF 2.07)

11.    Lee AL, Wang Y, Pervaiz S, Fan W and Yang YY. Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles. Macromol Biosci.11(2):296-307, 2011 (IF 3.89)

12.    Sui M, Zhang H and Fan W.* The Role of Estrogen and Estrogen Receptors in Chemoresistance, Curr Med Chem. 18:4674-4683, 2011 (IF 4.86)

13.    Lee AL, Dhillon SH, Wang Y, Pervaiz S, Fan W and Yang YY. Synergistic anti-cancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) and doxorubicin using micellar nanoparticles. Mol Biosyst. 7(5):1512-1522, 2011 (IF 3.53)

14.     Qin AJ1,Zhang Y, Han N, Mei J, Sun JZ, Fan W and Tang BZh, Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics, Science China Chem. 55:772-778, 2012 (IF 1.52)

15.     Zou WB, Zheng, HL, He TC, Chang JJ, Fu, YX and Fan W.* Mesenchymal Stem Cells Mediated-Delivery of LIGHT Targets Tumors and Mobilizes Immune Cells for Tumor Control, Cancer Res.72:2980-2989, 2012 (IF 9.28)

16.    Chang J, Sui M and Fan W.* Estrogen Receptor alpha Attenuates Therapeutic Efficacy of Paclitaxel on Breast Xenograft Tumors, Breast Cancer Res Treat. 134:969-980, 2012 (IF 4.47)

17.    Sui M, Zhang H, Di X, Chang J, Shen Y and Fan W.* G2 Checkpoint Abrogator Abates the Antagonistic Interaction between Antimicrotubule Drugs and Radiation Therapy. Radiotherapy and Oncology, 104:243-248, 2012 (IF 5.58)

18.    Liu L, Huang Y, Riduan SN, Gao S, Yang Y, Fan W.* and Zhang Y.* Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent. Biomaterials.33:8625-8631, 2012 (IF 8.31)

19.    Liu SQ, Yang C, Huang Y, Ding X, Li Y, Fan W, Hedrick JL, and Yang YY. Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition. Adv Materials, 24(48):6484-6489,2012 (IF 15.41)

20.    Huang Y; Wiradharma N, Xu, K, Ji ZK, Sheng Bi; Li L, Yang YY and Fan W.* Cationic amphiphilic α-helical peptides against carbapenem-resistant Acinetobacter baumannii infection. Biomaterials, 33:8841-8847, 2012 (IF 8.31)

21.  Fukushima K, Tan JP, Korevaar PA, Yang YY, Pitera J, Nelson A, Maune H, Coady DJ, Frommer JE, Engler AC, Huang Y, Xu K, Ji Z, Qiao Y, Fan W, Li L, Wiradharma N, Meijer EW, Hedrick JL. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano. 6:9191-9199, 2012 (IF 12.03)

22.   Chang J and Fan W.* Endocrine Therapy Resistance: Current Status, Possible Mechanisms and Overcoming Strategies. Anticancer Agent Med Chem, 13:464-475,2013 (IF 2.86)

23.   Li Y, Fukushima K, Coady DJ, Engler AC, Liu S, Huang Y, Cho JS, Guo Y, Miller LS, Tan JP, Ee PL, Fan W, Yang YY, Hedrick JL. Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies. Angew Chem Int Ed Engl. 52: 674-678, 2013 (IF 13.45)

24.    Chen C, Wang Y, Goh SL, Yang J, Lam DH, Chouhury Y, Tay FC, DS, Tan W, Purwanti YI, Fan W and Wang S. Inhibition of neuronal nitric oxide synthase activity promotes migration of human induced pluripotent stem cell-derived neural stem cells towards cancer cells. J. Neurochem. 126:318-330, 2013 (IF 4.06)

25.    Huang Y, Fu PF, Fan W.* Novel Targeted Therapies to overcome Trastuzumab Resistance in HER2-Overexpressing Metastatic Breast Cancer. Current Drug Targets, 14:889-898, 2013 (IF 3.56)

26.   Jiang DH, Sui M, Zhong WY, Huang Y. and Fan W.* Different Administration Strategies with Paclitaxel Induce Distinct Phenotypes of Multidrug Resistance in Breast Cancer Cells. Cancer Letters, 335: 404-411, 2013 (IF 5.61)

27.     Shahbazi M, Kwang TW,Purwanti YI, Fan W and Wang S. Inhibitory effects of neural stem cells derived from human embryonic stems on differention and function of monocyte-dendritic cells. J. Neurol Sciences, 330:65-93, 2013 (IF 2.35)

28.    Huang H, Weaver A, Wu E, Gao H, Fan W, Wu M. Lipid based signaling modulates DNA repair response and survival against Klebsiella pneumoniae infection in host cells and in mice. Am J Respir Cell Mol Biol, 49:798-807, 2103 (IF 5.13)

29.     Zhu D, Lam DH, Purwanti Y, Goh S, Wu C, Zeng J, Fan W and Wang S. Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells, Mol Therapy, 21:1621-1630, 2013 (IF 7.04)

30.    Han N, Yang YY, Wang S, Zheng S. and Fan W.* Polymer-based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics. Current Drug Matab, 14:661-674, 2013 (IF 5.11)

31.    Tay FC, Tan WK, Goh SL, Ramachandra CJ, Lau CH, Zhu H, Chen C, Du C, Phang RZ, Shahbazi M, Fan W., and Wang S* Targeted Transgene Insertion into the AAVS1 Locus Driven by Baculoviral Vector-mediated Zinc Finger Nuclease Expression in Human Induced Pluripotent Stem Cells. J. Gene Med, 15:384-395, 2013 (IF 3.08)

32.    Phang RZ, Tay FCm Goh CA, Tan WK, Liang Q, Chen C, Du S, Li ZD, Kang JC, Zeng J, Fan W, Toh H and Wang S. Zinc Finger Nucleas-Expressing Baculovrial Vectors Mediate Target Genome Integration of Reprogramming Facotr Genes to Facilitate the Geration of Human Induced Puripotent Stem Cells. Stem Cells Trans Med. 2(12): 935-945, 2013 (IF 5.71)

33.    Chin W, Yang C, Ng V, Huang Y, Cheng CJ,Tong Y, Coady DJ, Fan W, Hedrick J, Yang YY. Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity. Macromolecules. 46: 8797-8807, 2013 (IF 5.80]

34.    Fukushima K, Liu S, Wu H, Engler A, Coady D, Maune H, Pitera J, Nelson A, Wiradharma N, Venkataraman S, Huang Y, Fan W, Ying J, Yang YY. Supramolecular High Aspect Ratio Assemblies with Strong Antifungal Activity. Nature Commun.,4:2861-2869, 2013 (IF 11.47)

35.  Ong Z, Cheng J, Huang Y, Xu K, Ji Z, Fan W. and Yang YY. Effect of Stereochemsitry, Chain Length and Sequence pattern on antimicrobial properties of Short Synthetic beta-sheet Forming Peptide Amphiphiles. Biomaterials, 35:1315-1325, 2014 (IF 8.56)

36.  Purwanti YI, Chen C, Lam DH, Wu C, Zeng J, Fan W, and Wang S. Antitumor Effects of CD40 Ligand-expressing Endothelial Progenitor Cells Derived from Human iPS Cells in a Metastatic Breast Cancer Model, Stem Cells Trans Med. 3:923-935, 2014 (IF 5.71)

37 Zhu HD, Lau C, Goh S, Liang Q, Chen C, Du S, Phang RZ, Tay FC, Tan WK, Li Z, Tay JC, Fan W and Wang S. Baculoviral Transduction Facilitates TALEN-Mediated Targeted Transgene Integration and Cre/LoxP Cassette Exchange in Human-Induced pluripoten Stem Cells. Nucl Acid Res. Aug. 13, 2013 [Epub Ahead of Print] (IF 9.11)

38.    Wu M, Gan CP, Li RP, Ye Y, Zhang S, Yang YY, Fan W, Wu M. A novel chemosynthetic peptide with β-sheet motif efficiently kills Klebsiella pneumoniae in a mouse model. Intl J Nanomedicine. 10:1045-1059, 2015 (IF 4.38)

39.   Jiang DH, Huang H,Han N, Xu M, Xu L,Zhou L, Wang S. and Fan W*. Fulvestrant, a Selective Estrogen Receptor Down-regulator, Sensitizes Estrogen Receptor Negative Breast Tumors to Chemotherapy. Cancer Letters, 346:292-299, 2014 (IF 5.61)

40.   Fan W*, Chang JJ and Fu PF. Endocrine Therapy Resistance in Breast Cancer: Current Status, Possible Mechanisms and Overcoming Strategies. Future Medicinal Chem, 7:1511-1519, 2015 (IF 3.74)

41.   Xu L, lei JY, Jiang DH, Zhou L, Wang S and Fan W*. Reversal effects of raloxifene on paclitaxel resistance in two MDR breast cancer cells. Cancer Biology Thearpy. In Press, 2015 (IF 3.01)

42.   Cheng JC, Chin W, Dong WW, Xu L, Zhong GS, Huang Y, Li LJ, Xu K, Wu M, Hedrick JL, Yang YY and Fan W*. Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy against Multidrug-Resistant MRSA Systemic Infection. Adv. Healthcare Materials. [Epub Ahead of Print] 2015 (IF 5.80)

43.  Xu MJ, Jiang D, Shen J, Zheng H, Fan W.* Distinct characterization of two vinorelbine-resistant breast cancer cell lines developed by different strategies. Oncol Reports ; 35(4):2355-23632016

44.   Zhong G, Cheng J, Liang ZC, Xu L, Lou W, Bao C, Ong ZY, Dong H, Yang YY, Fan W*. Short Synthetic β-Sheet Antimicrobial Peptides for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Burn Wound Infections. Adv Healthc Materials. 6(7). 2017

45.   Huang Y, Jiang DH, Sui M, Wang X, Fan W.* Fulvestrant reverses doxorubicin resistance in multidrug-resistant breast cell lines independent of estrogen receptor expression.  Oncology Report. 3706-3712, 2017

46.  Xu M, Jiang D, Shen J, Zheng H, Fan W.* Distinct characterization of two vinorelbine-resistant breast cancer cell lines developed by different strategies. Oncol Reports, 37: 705-712, 2017

47.   Shen J, Pan J, Du C, Si W, Yao M, Xu LZheng HXu MChen DWang S, Fu P. Fan W*. Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer.  Cell Death Diseases. 82740- 2748, 2017

48.   Pan J, Shen JY, Xu L, Fan W* Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway. Oncotarget, In Press, 2017

 

BOOK CHAPTERS

1.Fan W*. and Sui M. Glucocorticoids Mediate Drug Resistance: Mechanisms and Its Clinical Impact. In Book Glucocorticoids: Effects, Action. Mechanism, and Therapeutic Uses. pp147-167Pelt, A.C. (eds), Nova Science Publishers, 2010

2.Fan W*. and Sui M: Roles and Mechanisms of Estrogen and Estrogen Receptors in Breast Cancer Resistant to Chemotherapy. In Book “Breast Cancer: Current and Alternative Therapeutic Modalities" Cells”Gunduz E (eds). InTech Publishers, 2011 (*This book charpter has been downloaded more than 2000 times by the readers over 100 countries)

3.Chang, JJ and Fan W*, Endocrine Therapy Resistance In Breast Cancer: Current Status, Possible Mechanisms and Overcoming Strategies. In Book "Medicinal chemistry advances: overcoming multidrug resistance in oncology". Ryan De Vooght-Johnson (eds). In Press, Future Science Ltd,UK. 2014

 

技术专利 (Patents)

1.源于BCap37的乳腺癌耐药细胞株及其应用。范伟民,蒋东海,隋梅花。专利申请号:201010502654.6;发明专利证书号:CN 1149981

2.氟维司群在制备抗微管类化疗药物耐药逆转剂中的应用。范伟民,蒋东海,隋梅花。专利申请号:201110047575.5;公开(公告)号:CN102151277A

 

研究课题 (Research Grants)

1.多功能纳米颗粒技术与新型抗癌药物的研究和开发(浙江省科技厅国际重大专项)10/2008-09/2011 项目主持人

2.新型靶向性纳米生物化疗药物治疗HER2+乳腺癌的体内外研究(国家自然科学基金)01/2010-12/2012,  项目主持人

3. 杭州抗体与靶向治疗研发技术平台(杭州市新药港建设委员会)8/2010-7/2012

4.雌激素受体介导乳腺癌对紫杉醇耐药及其逆转途径的体内研究(国家自然科学基金)01/2011-12/2013 项目主持人

5.   MSC-L的抗肿瘤基质细胞作用及其抑癌功效的研究(国家自然科学基金)01/2014-12/2016 80万) 项目主负责人

6.   新型抗菌药物β-折叠抗菌肽的临床前研究 (国家科技重大专项:重大新药创制)05/2016-04/2019 , 项目主持人

7.   浙江省科技厅重大专项:(项目编号:2015 C-24000)。项目名称:新型抗菌药物alpha-折叠抗菌肽的研发。2015/10/01-2018/9/30 项目负责人 

8.   miRMA-20-20a-5p家族调控家族乳腺癌耐受紫杉醇的作用机制研究及其临床意义(国家自然科学基金)01/2016-12/2019,  项目主持人

9.   新型抗菌多聚物对临床耐药细菌的杀伤作用及其机制研究 (国家自然科学基金) 01/2018 -12/2021  (Pending), 项目负责人

  

 

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地址:浙江杭州余杭塘路866 电话:0571-88208778  邮箱fanw@zju.edu.cn