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基本信息:

姓名: 余红
职务:
职称: 主任医师
学历: 博士
专业: 心血管生物学
所属院系: 浙医二院
研究方向: 干细胞治疗心血管疾病;干细胞动员,迁移,归巢和分化机制,及其在心血管组织修复中的作用;衰老对干细胞生物活性及其促血管新生能力的影响;干细胞分泌的外泌体exosome对心血管病的影响,血管钙化的防治。
电话: 0571-87783992
信箱: yuvascular@163.com
个人主页:

个人简介:

浙江大学求是特聘教授,浙江省“千人计划”特聘专家, 美国心脏协会会士(Fellow of AHA)。长期从事心血管生物学的研究,在干细胞治疗心血管疾病、及衰老对干细胞活性的影响等领域有深入的研究和积极的贡献。在Circulation Research,PNAS,ATVB, Stem Cell等国际著名学术期刊上发表论文七十余篇,以及6部书籍的章节。2011年回国后,已成功申请和参与了国家科技部973项目及重大科学研究计划项目和国家自然科学基金面上项目。

主要研究方向:干细胞治疗心血管疾病;干细胞动员,迁移,归巢和分化机制,及其在心肌修复中的作用;衰老对干细胞生物活性及其促血管新生能力的影响;干细胞分泌的外泌体exosome对心血管病的影响, 血管钙化的防 


学习和工作经历

19781982     上海复旦大学生物系            本科

19871993      美国南加州大学                     博士研究生

1997 2002  美国南加州大学医学院              助理教授

2003 2011    美国迈阿密大学医学院        副教授

2011现在       浙江大学求是特聘教授,     浙江省“千人计划”专家

 

近期发表的代表性论文

1.      JY Zhu, K Lu, N Zhang, Y Zhao, QC Ma, J Shen, YN Lin, PP Xiang, YL Tang, XY Hu, JH Chen , W Zhu, KA Webster, JA Wang, H Yu*.  Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artificial Cells, Nanomedicine and Biotechnology.  2017. In press.

2.      Hu DX, Nan JL, Sun Y, Zhu D, Xiao CC, Wang YP, Zhu LL, Wu Y, Zhao J, Wu RR, Chen JH, Yu H, Hu XY, Zhu W, Wang JA. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. PNAS, 2017, In press

3.      Yu Zhou, Panpan Chen, Qingnian Liu, Yingchao Wang, Ling Zhang, Rongrong Wu, Jinghai Chen, H Yu, Wei Zhu, Xin-yang Hu and Jian-An Wang.  Hepatoma-derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-reperfusion Injury.  Stem Cells International. 2017 . In press.

4.      Jin-Liang Nan; Wei Zhu; Rahman MS; Mingfei Liu; Sheng'an Su; Na Zhang; Dan Li; Xinyang Hu; Hong Yu; Mahesh P Gupta; Jian'an Wang. Molecular Regulation of Mitochondrial Dynamics in Cardiac Disease. BBA - Molecular Cell Research. In press. 2017 Jul; 1864(7):1260-1273.

5.      Hu DX, Z Zeng, W Zhu, N Zhang, H Yu, H Chen, K Wang, YC Wang, LM Wang, J Zhao, L Zhang, RR Wu, XY Hu, XB Liu, JA Wang.  SRT1720 Promotes Survival of Aged Human Mesenchymal Stem Cells via FAIM: a Pharmacological Strategy to Improve Stem Cell Based Therapy for Rat Myocardial Infarction。Cell Death and Disease. 2017  In press (IF 5.378)

6.      Yu H, K Lu, JY Zhu, JA Wang. Stem Cell Therapy for Ischemic Heart Disease. British Medical Bulletin. 2017 Feb 06 , 121 (1): 135-154. DOI: 10.1093/bmb/ldw059

7.      Wang C, H Chen, W Zhu, MF Liu, YC Xu, LL Zhu, F Yang, L Zhang, XB Liu, Z Zhong, J Zhao, J Jiang, M Xiang, Yu H, X Hu, H Lu, and JA Wang*. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells。Arteriosclero Thromb Vasc Biol. 2017 Jan; 37(1):53-65.

8.      Ma Q, X Xia, Q Tao, K Lu, J Shen, Q Xu, X Hu, Y Tang, NL Block, KA Webster, AV Schally, Wang J, H Yu*. Profound actions of an agonist of growth hormone releasing hormone on angiogenic therapy by mesenchymal stem cells. Arteriosclero Thromb Vasc Biol. 2016;36:663-672.

9.      Hu X, Y Xu, ZW Zhong, Y Wu, J Zhao, Y Wang, HF Cheng, MJ Kong, FJ Zhang, Q Chen, JZ Sun, Q Li, J Jin, QJ Li, LH Chen, C Wang, HW Zhan, Y Fan, Q Yang, L Yu, RR Wu, J Liang, JY Zhu, Y Wang, YP Jin, YF Lin, F Yang, LL Jian, W Zhu, JH Chen, H Yu, JY Zhang, J Wang. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization.  Circ Res. 2016. 118(6):970-83. 

10.  Xia XY, Q Tao, Q Ma, H Chen, JA Wang, and Yu H*. Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis, Stem Cells Int. 2016 Oct 20, Volume 2016 Article ID 8737589.

11.  Yang ZX, Wang YZ, Jia BB, Mao GX, Lv YD, Wang GF, Yu H*. Down-regulation of miR-146a,COX-2 and AGEs in simvastatin treated elder patients with hyperlipidemia  Geriatrics & Gerontology International  2016; 16:322-328. doi: 10.1111/ggi.12472.

12.  Yu H, K Lu, JA Wang. Treatment of heart failure after myocardial infarction with bone marrow-derived mesenchymal stem cells (Review). Cardiol Plus. 2015 Sept; 1(1) 17-23.

13.  Hu X, L Zhang, J Jin, W Zhu, Y Xu, Y Wu, Y Wang, H Chen, KA.Webster, H Chen, H Yu, J Wang. Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015, Jun;33(6):1850-62.

14.  X Hu, R Wu, Z Jiang, L Wang, P Chen, L Zhang, L Yang, Y Wu, H Chen, H Chen, Y Xu, Y Zhou, X Huang, KA Webster, H Yu*, JA Wang* . Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells, July 3, 2014; 32:2702–2713

15.  MS Zhou, A Wang, H Yu. Link between Insulin Resistance and Hypertension: What is the Evidence from Evolutionary Biology? Diabetology & Metabolic Syndrome.  2014 Jan 31,6:12. 1-8.  doi:10.1186/1758-5996-6-12.

16.  Z Zhang, J Wang, Y Xu, Z Jiang, R Wu, L Wang, P Chen, X Hu, H Yu. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction.  Intl J Cardiol 2013 Sep 30;168(2):1711-4. doi: 10.1016/j.ijcard.2013.03.126.

17.  Xu Q, Wang JA, He J, Zhou MS, Adi J, Webster K, Yu H.* Impaired CXCR4 Expression and Cell Engraftment of Bone Marrow-derived Cells from Aged Atherogenic Mice. Atherosclerosis. 219:92-99,  2011

18.  Shao H, Xu Q, Wu Q, Ma Q, Slgueiro L, Wang JA, Eton D, Webster K, Yu H.* Defective CXCR4 Expression in Aged Bone Marrow Cells Impairs Vascular Regeneration. J Cell Mol Med. 15(10):2046-2056, 2011。

19.  Eton D, Yu H. Enhanced Cell Therapy Strategy to Treat Chronic Limb Threatening Ischemia. J Vasc Surg. 52(1):199-204; 2010 doi:10.1016/j.jvs.2009.12.048 (IF 3.772)

20.  Wu Q., Shao H, D. Eton, J Li. B Yang, M. G. Uberti, KA Webster, H. Yu*  Extracellular calcium increases CXCR4 Expression on Bone Marrow-derived Cells and Enhances Pro-Angiogenesis Therapy.  J Cell Mol Med. 13(9B):3764-3773. 2009.

21.  Shao H, Tan, Y, D. Eton, Z. Yang, M. G. Uberti, S Li, A. Schulick, H. Yu*  Statin and Stromal Cell Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels.  Stem Cells. 26(5):1376-1384, 2008。